Sotoudeh, N Namavar, M R Zarifkar, A Heidarzadegan, A R
Published in
IBRO reports
Aging affects different parts of the brain structure and function. These changes are associated with several age-related emotional alterations like anxiety that is regulated by the amygdala and medial prefrontal cortex (mPFC). Thus, this study aimed to explore the effects of aging on the morphology changes in these regions. Twenty male Wistar rats ...
Ahiawodzi, Peter Fitzpatrick, Annette L Djousse, Luc Ix, Joachim H Kizer, Jorge R Mukamal, Kenneth J
Published in
Metabolism open
Telomeres shorten as organisms age, placing limits on cell proliferation and serving as a marker of biological aging. Non-esterified fatty acids (NEFAs) are a key mediator of age-related metabolic abnormalities. We aimed to determine if NEFAs are associated with telomere length in community-living older adults. We cross-sectionally studied 1648 par...
Maleki, Masomeh Khelghati, Nafiseh Alemi, Forough Bazdar, Mahtab Asemi, Zatollah Majidinia, Maryam Sadeghpoor, Alireza Mahmoodpoor, Ata Jadidi-Niaragh, Farhad Targhazeh, Nilofar
...
Published in
Life sciences
Aging is a form of a gradual loss of physiological integrity that results in impaired cellular function and ultimately increased vulnerability to disease and death. This process is a significant risk factor for critical age-related disorders such as cancer, diabetes, cardiovascular disease, and neurological conditions. Several mechanisms contribute...
Ullah, Rahat Jo, Myeung Hoon Riaz, Muhammad Alam, Sayed Ibrar Saeed, Kamran Ali, Waqar Rehman, Inayat Ur Ikram, Muhammad Kim, Myeong Ok
Published in
Journal of Neuroinflammation
BackgroundGlycine is the smallest nonessential amino acid and has previously unrecognized neurotherapeutic effects. In this study, we examined the mechanism underlying the neuroprotective effect of glycine (Gly) against neuroapoptosis, neuroinflammation, synaptic dysfunction, and memory impairment resulting from d-galactose-induced elevation of rea...
Binyamin, Dana Werbner, Nir Nuriel-Ohayon, Meital Uzan, Atara Mor, Hadar Abbas, Atallah Ziv, Oren Teperino, Raffaele Gutman, Roee Koren, Omry
...
Published in
Genome Medicine
BackgroundDuring aging, there is a physiological decline, an increase of morbidity and mortality, and a natural change in the gut microbiome. In this study, we investigated the influence of the gut microbiome on different metabolic parameters in adult and aged mice.MethodsFecal and blood samples from adult (n = 42, 100–300 days) and aging (n = 32, ...
Church, Sophie Rogers, Emily Rockwood, Kenneth Theou, Olga
Published in
BMC Geriatrics
BackgroundFrailty is increasingly recognized as an important construct which has health implications for older adults. The Clinical Frailty Scale (CFS) is a judgement-based frailty tool that evaluates specific domains including comorbidity, function, and cognition to generate a frailty score ranging from 1 (very fit) to 9 (terminally ill). The aim ...
Guligowska, Agnieszka Corsonello, Andrea Pigłowska, Małgorzata Roller-Wirnsberger, Regina Wirnsberger, Gerhard Ärnlöv, Johan Carlsson, Axel C. Tap, Lisanne Mattace-Raso, Francesco Formiga, Francesc
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Published in
BMC Geriatrics
BackgroundDifferent mechanisms connect the nutritional status with the occurrence and the course of chronic kidney disease (CKD). The end-stage renal disease is complicated by catabolic inflammatory reactions and cachexia which leads to malnutrition (undernutrition). On the other hand, obesity is an important risk factor for the development and acc...
Kukkemane, Kowshik Jagota, Anita
Published in
Biogerontology
The temporal expression pattern of the circadian clock genes are known to be altered/attenuated with advance in age. Withania somnifera (WS) essentially consists of numerous active constituents including withanolides is known to have antioxidant, anti-inflammatory and adaptogenic properties. We have earlier demonstrated therapeutic effects of hydro...
Panossian, Annabelle Cave, Michael W Patel, Bhavik A Brooks, Emily L Flint, Melanie S Yeoman, Mark S
Published in
Mechanisms of ageing and development
Social isolation (SI) is a major health risk in older people leading to cognitive decline. This study examined how SI and age influence performance in the novel object recognition (NOR) and elevated plus maze (EPM) tasks in C57BL/6 mice aged 3 or 24 months. Mice were group-housed (groups of 2-3) or isolated for 2 weeks prior to experimentation. Fol...
Imerb, Napatsorn Thonusin, Chanisa Chattipakorn, Nipon Chattipakorn, Siriporn C
Published in
Mechanisms of ageing and development
Aging, obesity, and insulin resistance are known to cause the impairment of bone regulation, resulting in an imbalance in bone homeostasis and pathological bone. The natural deterioration associated with the aging process, including increased adipogenicity, menopause, andropause and alteration of mesenchymal stem cell fate have been shown to be pot...
