Nature of inhibition abilities in aging: A multimodal working memory approach. Preliminary results.
Peer reviewed
Androgens enhance neurogenesis in young males
Graduate
Chronic Rhinosinusitis with Nasal Polyps in Older Adults: Clinical Presentation, Pathophysiology, and Comorbidity
Published in Current Allergy and Asthma Reports
Purpose of ReviewChronic rhinosinusitis and nasal polyps (CRSwNP) is a common condition that significantly affects patients’ life. This work aims to provide an up-to-date overview of CRSwNP in older adults, focusing on its aging-related clinical presentations, pathophysiology, and comorbidity associations including asthma.Recent FindingsRecent larg...
Reduced expression of the Ion channel CFTR contributes to airspace enlargement as a consequence of aging and in response...
Published in Respiratory Research
Chronic Obstructive Pulmonary Disease (COPD) is a complex disease resulting in respiratory failure and represents the third leading cause of global death. The two classical phenotypes of COPD are chronic bronchitis and emphysema. Owing to similarities between chronic bronchitis and the autosomal-recessive disease Cystic Fibrosis (CF), a significant...
The presence of CLL-associated stereotypic B cell receptors in the normal BCR repertoire from healthy individuals increa...
...Published in Immunity & Ageing
BackgroundAging is known to induce immunosenescence, resulting in alterations in both the innate and adaptive immune system. Here we evaluated the effects of aging on B cell subsets in peripheral blood of 155 immunologically healthy individuals in four age categories (range 20-95y) via multi-parameter flow cytometry. Furthermore, we studied the nai...
Ischemia and reperfusion injury following cardioplegic arrest is attenuated by age and testosterone deficiency in male b...
Published in Biology of Sex Differences
BackgroundCardiovascular disease increases with age in both sexes. Treatment can require cardiac surgery, where the hearts are pre-treated with protective cardioplegic solution before ischemia and reperfusion (I/R). While endogenous estrogen is beneficial in I/R, whether testosterone is involved is uncertain and whether age modifies responses to I/...
Peripheral antibody concentrations are associated with highly differentiated T cells and inflammatory processes in the h...
Published in Immunity & Ageing
BackgroundAntigen-experienced immune cells migrate back to the bone marrow (BM), where they are maintained in BM survival niches for an extended period. The composition of T cell subpopulations in the BM changes with age, leading to an accumulation of highly differentiated T cells and a loss of naïve T cells. While innate immune cells are also affe...
Recurrent circadian fasting (RCF) improves blood pressure, biomarkers of cardiometabolic risk and regulates inflammation...
Published in Journal of Translational Medicine
BackgroundThe effects of fasting on health in non-human models have been widely publicised for a long time and emerging evidence support the idea that these effects can be applicable to human practice.MethodsIn an open label longitudinal follow-up, a cohort of 78 adult men (aged 20 to 85 years) who fasted for 29 consecutive days from sunrise to sun...
Novel age-associated DNA methylation changes and epigenetic age acceleration in middle-aged African Americans and whites...
...Published in Clinical Epigenetics
BackgroundAfrican Americans (AAs) experience premature chronic health outcomes and longevity disparities consistent with an accelerated aging phenotype. DNA methylation (DNAm) levels at specific CpG positions are hallmarks of aging evidenced by the presence of age-associated differentially methylated CpG positions (aDMPs) that are the basis for the...
The interplay of aging, genetics and environmental factors in the pathogenesis of Parkinson’s disease
Published in Translational Neurodegeneration
BackgroundParkinson’s disease (PD) is characterized by dopaminergic neuronal loss in the substantia nigra pars compacta and intracellular inclusions called Lewy bodies (LB). During the course of disease, misfolded α-synuclein, the major constituent of LB, spreads to different regions of the brain in a prion-like fashion, giving rise to successive n...
