Taylor, Erik N. Huang, Nasi Wisco, Jonathan Wang, Yandan Morgan, Kathleen G. Hamilton, James A.
Published in
Journal of Translational Medicine
BackgroundBrain aging is a major risk factor in the progression of cognitive diseases including Alzheimer’s disease (AD) and vascular dementia. We investigated a mouse model of brain aging up to 24 months old (mo).MethodsA high field (11.7T) MRI protocol was developed to characterize specific features of brain aging including the presence of cerebr...
Kang, Min Soo Kim, Woosuk Kim, Tae Hyeong Jung, Hyo Young Kwon, Hyun Jung Kim, Dae Won Hwang, In Koo Choi, Jung Hoon
Published in
Laboratory Animal Research
Fat-mass and obesity-associated protein (Fto) is highly expressed in the brain including, the hippocampus, and its expression is significantly decreased in the brain of Alzheimer’s disease patients. In the present study, we measured Fto immunoreactivity and protein levels in the hippocampus of obese and aged mice, which were induced by high-fat die...
Bitetto, Giacomo Di Fonzo, Alessio
Published in
Translational Neurodegeneration
In the ongoing process of uncovering molecular abnormalities in neurodegenerative diseases characterized by toxic protein aggregates, nucleo-cytoplasmic transport defects have an emerging role. Several pieces of evidence suggest a link between neuronal protein inclusions and nuclear pore complex (NPC) damage. These processes lead to oxidative stres...
Park, So Young Kim, Jung Hee Choi, Hyung Jin Ku, Eu Jeong Hong, A. Ram Lee, Ji Hyun Shin, Chan Soo Cho, Nam H.
Published in
Archives of Osteoporosis
SummaryThe bone mineral densities (BMDs) of the femoral neck and total hip, and the lumbar spine trabecular bone score (TBS), tended to decrease with age in both men and women, whereas the lumbar spine BMD tended to increase. Lumbar spine BMD is thus inappropriate for evaluating longitudinal changes in bone loss; the lumbar spine TBS is an alternat...
Hwang, Ye In Foley, Kitty-Rose Trollor, Julian N
Published in
Journal of autism and developmental disorders
There is a gap in our knowledge of aging with autism. The present study examined the applicability of the popular gerontology concept of "aging well" to autistic adults. Using survey data, a model of "aging well" was operationalised and applied to 92 autistic adults and 60 controls. A very small proportion (3.3%) of autistic adults were found to be...
McDonough, Ian M McDougall, Graham J LaRocca, Michael Dalmida, Safiya G Arheart, Kristopher L
Published in
Aging & mental health
Objective: Subjective memory concerns (SMCs) might be an early indicator of future cognitive decline and conversion to dementia. However, a rich history of mixed findings, moderating factors, and heterogenous methods preclude the usefulness of SMCs in both research and clinical settings. The present study aimed to review some of the factors that mi...
Intzandt, Brittany Sabra, Dalia Foster, Catherine Desjardins-Crépeau, Laurence Hoge, Richard D Steele, Christopher J Bherer, Louis Gauthier, Claudine J
Published in
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Aging is accompanied by vascular and structural changes in the brain, which include decreased grey matter volume (GMV), cerebral blood flow (CBF), and cerebrovascular reactivity (CVR). Enhanced fitness in aging has been related to preservation of GMV and CBF, and in some cases CVR, although there are contradictory relationships reported between CVR...
Shveiky, David Iglesia, Cheryl B Sarkar Das, Srilekha Ben Menachem-Zidon, Ofra Chill, Henry H Ji, Hong Sandberg, Kathryn
Published in
International urogynecology journal
Surgical repair of pelvic organ prolapse often includes native tissue repair during which the patient's own vaginal connective tissue is used to achieve pelvic support. This method, based on plication and suspension often yields suboptimal anatomical outcomes, possibly due to inadequate healing of the vaginal connective tissue. We hypothesized that...
Bialystok, Ellen Dey, Avanti Sullivan, Margot D Sommers, Mitchell S
Published in
Memory & cognition
Both languages are jointly activated in the bilingual brain, requiring bilinguals to select the target language while avoiding interference from the unwanted language. This cross-language interference is similar to the within-language interference created by the Deese-Roediger-McDermott false memory paradigm (DRM; Roediger & McDermott, 1995, Journa...
Dimitriadou, Maria Michaelides, Michalis P Bateman, Andrew Constantinidou, Fofi
Published in
Neuropsychological rehabilitation
The Dysexecutive Questionnaire is a sensitive and ecologically valid measure of everyday dysexecutive symptoms. Recently, a revised version of the tool has been proposed (DEX-R). The current study aimed to examine the factorial validity of the Greek DEX-R, the level of agreement between the self and informant rating versions and the effect of age o...
