A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity.
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Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies.
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Breast cancer management pathways during the COVID-19 pandemic: outcomes from the UK 'Alert Level 4' phase of the B-MaP-...
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Assessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England
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The SARS-CoV-2 lineage B.1.1.7, designated a Variant of Concern 202012/01 (VOC) by Public Health England1, originated in the UK in late Summer to early Autumn 20202. Whole genome SARS-CoV-2 sequence data collected from community-based diagnostic testing shows an unprecedentedly rapid expansion of the B.1.1.7 lineage during Autumn 2020, suggesting a...
Safety profile of enhanced thromboprophylaxis strategies for critically ill COVID-19 patients during the first wave of t...
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Introduction Critical illness from SARS-CoV-2 infection (COVID-19) is associated with a high burden of pulmonary embolism (PE) and thromboembolic events despite standard thromboprophylaxis. Available guidance is discordant, ranging from standard care to the use of therapeutic anticoagulation for enhanced thromboprophylaxis (ET). Local ET protocols ...
Evaluating the impact of curfews and other measures on SARS-CoV-2 transmission in French Guiana.
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Genomic epidemiology of COVID-19 in care homes in the east of England.
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COVID-19 poses a major challenge to care homes, as SARS-CoV-2 is readily transmitted and causes disproportionately severe disease in older people. Here, 1,167 residents from 337 care homes were identified from a dataset of 6,600 COVID-19 cases from the East of England. Older age and being a care home resident were associated with increased mortalit...
Timing of surgery following SARS‐CoV‐2 infection: an international prospective cohort study
Peri‐operative SARS‐CoV‐2 infection increases postoperative mortality. The aim of this study was to determine the optimal duration of planned delay before surgery in patients who have had SARS‐CoV‐2 infection. This international, multicentre, prospective cohort study included patients undergoing elective or emergency surgery during October 2020. Su...
Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective coh...
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Background Prognostic models to predict the risk of clinical deterioration in acute COVID-19 cases are urgently required to inform clinical management decisions. Methods We developed and validated a multivariable logistic regression model for in-hospital clinical deterioration (defined as any requirement of ventilatory support or critical care, or ...
Breast Cancer Risk Genes - Association Analysis in More than 113,000 Women.
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Background Gene-panel testing for breast cancer susceptibility is widely used, but for many genes, the evidence for association with breast cancer is weak, underlying risk estimates are imprecise, and reliable subtype-specific risks are lacking. Methods We performed gene panel sequencing for 34 putative susceptibility genes on samples from 60,466 f...
