Jenks, Alan D. Hoekstra, Trynke Axén, Iben de Luca, Katie Field, Jonathan Newell, Dave Hartvigsen, Jan French, Simon D. Koes, Bart van Tulder, Maurits W.
...
Published in
Chiropractic & Manual Therapies
BackgroundLow back pain is a common condition among older adults that significantly influences physical function and participation. Compared to their younger counterparts, there is limited information available about the clinical course of low back pain in older people, in particularly those presenting for chiropractic care. Improving our understan...
Taylor, Andrea Broadbent, Marc Gurung, Apil Wallis, Marianne
Published in
International emergency nursing
The universal screening and comprehensive assessment of older persons presenting to the emergency department is considered useful, yet is difficult to embed. A number of assessment instruments exist however they are not widely used and there is a lack of agreement between clinicians as to which tools are best suited to the emergency department. The...
Van Grootven, Bastiaan Jeuris, Anthony Jonckers, Maren Devriendt, Els Dierckx de Casterlé, Bernadette Dubois, Christophe Fagard, Katleen Herregods, Marie-Christine Hornikx, Miek Meuris, Bart
...
Published in
BMC Geriatrics
BackgroundUp to one in three of older patients who are hospitalised develop functional decline, which is associated with sustained disability, institutionalisation and death. This study developed and validated a clinical prediction model that identifies patients who are at risk for functional decline during hospitalisation. The predictive value of ...
Griebling, Tomas L. Campbell, Noll L. Mangel, Jeffrey Staskin, David Herschorn, Sender Elsouda, Dina Schermer, Carol R.
Published in
BMC Geriatrics
BackgroundAntimuscarinics are often used for treatment of overactive bladder (OAB), but exposure to medications such as antimuscarinics that have anticholinergic properties has been linked to adverse cognitive effects. A phase 4 placebo-controlled study (PILLAR; NCT02216214) described the efficacy and safety of mirabegron, a β3-adrenoreceptor agoni...
Kienle, G. S. Werthmann, P. G. Grotejohann, B. Kaier, K. Steinbrenner, I. Voigt-Radloff, S. Huber, R.
Published in
BMC Geriatrics
BackgroundIn elderly poeple, multimorbidity and polypharmacy increase while sensory, motor and cognitive functions decrease. Falls occur in 30% of people aged 65 years and older at least once per year, with injuries at 10–20%. Reducing falls and enhancing physical, emotional and cognitive capacities are essential for healthy aging despite chronic d...
Gordon, S. J. Baker, N. Kidd, M. Maeder, A. Grimmer, K. A.
Published in
BMC Geriatrics
BackgroundThere is little known about pre-frailty attributes or when changes which contribute to frailty might be detectable and amenable to change. This study explores pre-frailty and frailty in independent community-dwelling adults aged 40–75 years.MethodsParticipants were recruited through local council networks, a national bank and one universi...
Williams, Grant R Kenzik, Kelly M Parman, Mariel Al-Obaidi, Mustafa Francisco, Liton Rocque, Gabrielle B McDonald, Andrew Paluri, Ravi Navari, Rudolph M Nandagopal, Lakshmin
...
Published in
Journal of geriatric oncology
Integrating Geriatric Assessment (GA) in the management of older adults with cancer is recommended, yet rarely practiced in routine oncologic care. Our objective was to assess the feasibility of integrating routine GA in the management of older adults with gastrointestinal (GI) malignancies and characterize impairments in this population. Patients ...
Al-Katib, Ayad M Mohamed, Anwar N
Primary cutaneous B-cell lymphomas (PCBCL) are a heterogeneous group of mature B-cells neoplasms that present in the skin without evidence of nodal or systemic involvement. The clinical and pathologic features of PCBCL differ significantly from the equivalent nodal lymphomas. Three main subtypes of PCBCL are recognized by the 2016 revised WHO class...
Branco, Paola Cristina Jimenez, Paula Christine Machado-Neto, João Agostinho Costa-Lotufo, Letècia Veras
BIRC8, also known as ILP-2, is a homologous protein of BIRC4, however, its function has seldom been addressed. Despite the similarity with other Inhibitory Apoptosis Proteins (IAPs), there is evidence that BIRC8 acts in a peculiar manner, by impeding apoptosis induced by BAX without directly inhibiting the activity of caspases. BIRC8 expression has...
Machado-Alba, Jorge Enrique Machado-Duque, Manuel Enrique Gaviria-Mendoza, Andrés
Published in
Diabetes research and clinical practice
To determine the time elapsed from when a patient ≥ 65 years old is diagnosed with type 2 diabetes mellitus (T2DM) and begins antidiabetic treatment until a change in treatment is required as well as the factors associated with the change. A retrospective study was conducted on patients 65 years or older with a first-time diagnosis of T2DM, and the...
