Seixas, Brayan V. Freitas, Gabriel R.
Published in
Pharmacy Practice
Background: Polypharmacy has become an increasingly public health issue as population age and novel drugs are developed. Yet, evidence on low- and middle-income countries (LMIC) is still scarce. Objective: This work aims to estimate the prevalence of polypharmacy among Brazilians aged 50 and over, and investigate associated factors. Methods: A cros...
Pearce, N Moirano, G Maule, M Kogevinas, M Rodo, X Lawlor, DA Vandenbroucke, J Vandenbroucke-Grauls, C Polack, FP Custovic, A
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The Covid-19 death rate increases exponentially with age, and the main risk factors are having underlying conditions such as hypertension, diabetes, cardiovascular disease, severe chronic respiratory disease and cancer. These characteristics are consistent with the multi-step model of disease. We applied this model to Covid-19 case fatality rates (...
Maforo, Nyasha G Magrath, Patrick Moulin, Kévin Shao, Jiaxin Kim, Grace Hyun Prosper, Ashley Renella, Pierangelo Wu, Holden H Halnon, Nancy Ennis, Daniel B
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BackgroundCardiovascular disease is the leading cause of death in patients with Duchenne muscular dystrophy (DMD)-a fatal X-linked genetic disorder. Late gadolinium enhancement (LGE) imaging is the current gold standard for detecting myocardial tissue remodeling, but it is often a late finding. Current research aims to investigate cardiovascular ma...
Burnworth, Melinda J. Pettinger, Tracy K. Medina, Melissa S. Niemczyk, Mary
Published in
Pharmacy Practice
Ideally, precepting during introductory and advanced pharmacy practice experiences should be tailored to meet the individualized needs of learners. Understanding generational similarities and differences that exist between both learners and educators will facilitate meaningful interaction and improve learning outcomes. A common pitfall among precep...
Izzi-Engbeaya, C Distaso, W Amin, A Kenkre, J Abdel-Malek, M Hope, D Oliver, N Misra, S Tan, T Hill, N
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INTRODUCTION: Patients with diabetes mellitus admitted to hospital with COVID-19 have poorer outcomes. However, the drivers for this are not fully elucidated. We performed detailed characterisation of COVID-19 patients to determine clinical and biochemical factors that may be the drivers of poorer outcomes. RESEARCH DESIGN AND METHODS: Retrospectiv...
Wang, Allen Chiou, Joshua Poirion, Olivier B Buchanan, Justin Valdez, Michael J Verheyden, Jamie M Hou, Xiaomeng Kudtarkar, Parul Narendra, Sharvari Newsome, Jacklyn M
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Respiratory failure associated with COVID-19 has placed focus on the lungs. Here, we present single-nucleus accessible chromatin profiles of 90,980 nuclei and matched single-nucleus transcriptomes of 46,500 nuclei in non-diseased lungs from donors of ~30 weeks gestation,~3 years and ~30 years. We mapped candidate cis-regulatory elements (cCREs) and...
Stilhano, Roberta Sessa Costa, Angelica Jardim Nishino, Michelle Sayuri Shams, Shahin Bartolomeo, Cynthia Silva Breithaupt-Faloppa, Ana Cristina Silva, Eduardo Alexandre Ramirez, Ana Lopez Prado, Carla Maximo Ureshino, Rodrigo Portes
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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has provoked major stresses on the health-care systems of several countries, and caused the death of more than a quarter of a million people globally, mainly in the elderly population with preexisting pathologies. Previous studies with coronavirus (SARS-CoV) point to gender d...
Lee, Ivan T Nakayama, Tsuguhisa Wu, Chien-Ting Goltsev, Yury Jiang, Sizun Gall, Phillip A Liao, Chun-Kang Shih, Liang-Chun Schürch, Christian M McIlwain, David R
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The coronavirus SARS-CoV-2 is the causative agent of the ongoing severe acute respiratory disease pandemic COVID-19. Tissue and cellular tropism is one key to understanding the pathogenesis of SARS-CoV-2. We investigate the expression and subcellular localization of the SARS-CoV-2 receptor, angiotensin-converting enzyme 2 (ACE2), within the upper (...
Shi, Ting Arnott, Andrew Semogas, Indre Falsey, Ann R Openshaw, Peter Wedzicha, Jadwiga A Campbell, Harry Nair, Harish
Published in
The Journal of infectious diseases
Acute respiratory tract infections (ARI) constitute a substantial disease burden in adults and elderly individuals. We aimed to identify all case-control studies investigating the potential role of respiratory viruses in the etiology of ARI in older adults aged ≥65 years. We conducted a systematic literature review (across 7 databases) of case-cont...
Burn, Edward You, Seng Chan Sena, Anthony G Kostka, Kristin Abedtash, Hamed Abrahão, Maria Tereza F Alberga, Amanda Alghoul, Heba Alser, Osaid Alshammari, Thamir M
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Comorbid conditions appear to be common among individuals hospitalised with coronavirus disease 2019 (COVID-19) but estimates of prevalence vary and little is known about the prior medication use of patients. Here, we describe the characteristics of adults hospitalised with COVID-19 and compare them with influenza patients. We include 34,128 (US: 8...
