Rengifo, Carla
T-Cell Phenotypes Associated with Oesophagogastric Adenocarcinoma Introduction: In the UK in 2016, approximately 16,000 new cases of oesophagogastric cancer were diagnosed. Chemotherapy and surgery are the mainstay of treatment but are associated with considerable morbidity and overall survival rates are dismally low. Worryingly the incidence of oe...
Shourian, Mitra Beltra, Jean-Christophe Bourdin, Benoîte Decaluwe, Hélène
Published in
Seminars in immunology
Overcoming exhaustion-associated dysfunctions and generating antigen-specific CD8 T cells with the ability to persist in the host and mediate effective long-term anti-tumor immunity is the final aim of cancer immunotherapy. To achieve this goal, immuno-modulatory properties of the common gamma-chain (γc) family of cytokines, that includes IL-2, IL-...
Cappuzzello, Elisa Sommaggio, Roberta Zanovello, Paola Rosato, Antonio
Published in
Cytokine & growth factor reviews
Cytokine-Induced killer (CIK) cells are raising growing interest in cellular antitumor therapy, as they can be easily expanded with a straightforward and inexpensive protocol, and are safe requiring only GMP-grade cytokines to obtain very high amounts of cytotoxic cells. CIK cells do not need antigen-specific stimuli to be activated and proliferate...
Garetto, Stefano Sardi, Claudia Martini, Elisa Roselli, Giuliana Morone, Diego Angioni, Roberta Cianciotti, Beatrice Claudia Trovato, Anna Elisa Franchina, Davide Giuseppe Castino, Giovanni Francesco
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Published in
Oncotarget
In recent years, tumor Adoptive Cell Therapy (ACT), using administration of ex vivo-enhanced T cells from the cancer patient, has become a promising therapeutic strategy. However, efficient homing of the anti-tumoral T cells to the tumor or metastatic site still remains a substantial hurdle. Yet the tumor site itself attracts both tumor-promoting a...
Puzzoni, Marco Silvestris, Nicola Leone, Francesco Giampieri, Riccardo Faloppi, Luca Demurtas, Laura Dell’Aquila, Emanuela Marino, Donatella Brunetti, Oronzo Garattini, Silvio Ken
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Published in
Targeted Oncology
The encouraging results in immunotherapy for melanoma also led the way for translational and clinical research about immune-related mechanisms possibly relevant for gastrointestinal tumours. It is in fact now evident that the immune checkpoint modulation and in particular cell-mediated immune-response through programmed cell death-1 (PD-1) and the ...
Li, Jinxia Zhao, Yuliang
Published in
Science Bulletin
Bharathan, Mini Trebska-McGowan, Katarina Anna, Pasetto Deniger, Drew C Hanada, Ken-ichi Gartner, Jared J Yang, James C Rosenberg, Steven A Robbins, Paul F
Published in
Journal for ImmunoTherapy of Cancer
Lametschwandtner, Guenther Sachet, Monika Haslinger, Isabella Mühleisen, Hannes Loibner, Hans
Published in
Journal for ImmunoTherapy of Cancer
Sarnaik, Amod Hall, MacLean Mullinax, John Royster, Erica Richards, Allison Crago, Georgina Zager, Jonathan Vernon, Sondak Weber, Jeffrey Pilon-Thomas, Shari
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Published in
Journal for ImmunoTherapy of Cancer
Hu, Xiao Moisan, Jacques Majchrzak, Kinga Lesch, Chuck Wang, Yahong Sanchez, Brian Liu, Xikui Morgan, Rodney Mertz, David Bousley, Dick
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Published in
Journal for ImmunoTherapy of Cancer