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T Cell Phenotypes Associated with Oesophagogastric Adenocarcinoma

T-Cell Phenotypes Associated with Oesophagogastric Adenocarcinoma Introduction: In the UK in 2016, approximately 16,000 new cases of oesophagogastric cancer were diagnosed. Chemotherapy and surgery are the mainstay of treatment but are associated with considerable morbidity and overall survival rates are dismally low. Worryingly the incidence of oe...

Common gamma chain cytokines and CD8 T cells in cancer.

Published in Seminars in immunology

Overcoming exhaustion-associated dysfunctions and generating antigen-specific CD8 T cells with the ability to persist in the host and mediate effective long-term anti-tumor immunity is the final aim of cancer immunotherapy. To achieve this goal, immuno-modulatory properties of the common gamma-chain (γc) family of cytokines, that includes IL-2, IL-...

Cytokines for the induction of antitumor effectors: The paradigm of Cytokine-Induced Killer (CIK) cells.

Published in Cytokine & growth factor reviews

Cytokine-Induced killer (CIK) cells are raising growing interest in cellular antitumor therapy, as they can be easily expanded with a straightforward and inexpensive protocol, and are safe requiring only GMP-grade cytokines to obtain very high amounts of cytotoxic cells. CIK cells do not need antigen-specific stimuli to be activated and proliferate...

Tailored chemokine receptor modification improves homing of adoptive therapy T cells in a spontaneous tumor model.

Published in Oncotarget

In recent years, tumor Adoptive Cell Therapy (ACT), using administration of ex vivo-enhanced T cells from the cancer patient, has become a promising therapeutic strategy. However, efficient homing of the anti-tumoral T cells to the tumor or metastatic site still remains a substantial hurdle. Yet the tumor site itself attracts both tumor-promoting a...