Published in Journal of Ovarian Research
BackgroundAdipocytes, active facilitators of epithelial ovarian cancer (EOC) growth, have been implicated in the link between obesity and EOC. However, the current understanding of the mechanisms underlying adipocyte-induced EOC cell proliferation remains incomplete.ResultsWe provide the first evidence showing that sphingosine kinase (SphK) 1 is cr...
Published in Breast Cancer Research
BackgroundAn abundance of tumor-associated macrophages has been shown to be an independent prognostic factor for a poor prognosis of human breast cancer (BC). Adipose tissue accounts for the largest proportion of the breast and has also been identified as an independent indicator of poor survival in BC. This study aims to elucidate if the influence...
Published in Human pathology
Although the morphologic diagnosis of hibernoma is usually straightforward, some hibernomas have atypical morphologic features, mimicking atypical lipomatous tumors/well-differentiated liposarcomas (ALT/WDLs). In addition, the multivacuolated brown fat cells may be mistaken for lipoblasts by pathologists, especially those without significant soft t...
Published in Chemosphere
Even though microplastic (MP) pollution in aquatic environment is nowadays widely studied, a huge gap of knowledge exists on their actual biological effects. In this study we first reported environmental baseline data on the occurrence and characterization of floating MPs in Italian coastal waters of the Central Adriatic Sea by using a standardized ...
Published in Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology
The constituents of normal cardiac valves as well as those involved by active and/or chronic processes have been detailed previously, however minor attention has been provided toward mature adipocytes within valves and correlation with other histologic, clinical, and echocardiographic data. The literature also contains a paucity of investigations e...
Published in World Journal of Stem Cells
BACKGROUND Mesenchymal stem cells (MSC) of bone marrow are the progenitor of osteoblasts and adipocytes. MSC tend to differentiate into adipocytes, instead of osteoblasts, with aging. This favors the loss of bone mass and development of osteoporosis. Hypoxia induces hypoxia inducible factor 1α gene encoding transcription factor, which regulates the...
Published in Heliyon
Japanese larch, Larix kaempferi , Taxifolin, Inflammation, Lipid accumulation, Adipocytes, Macrophages; Food science; Bioactive compound; Biochemical characterization of food; Plant products; Cell culture; Cytotoxicity; Polyphenol; Flavonoid; Alternative medicine.
Published in Clinical and molecular hepatology
Published in Molecular metabolism
Adipogenesis is critical for adipose tissue remodeling during the development of obesity. While the role of transcription factors in the orchestration of adipogenic pathways is already established, the involvement of coregulators that transduce regulatory signals into epigenome alterations and transcriptional responses remains poorly understood. Th...
