Biernacki, Kathryn Lopez-Guzman, Silvia Messinger, John C Banavar, Nidhi V Rotrosen, John Glimcher, Paul W Konova, Anna B
Published in
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
How does craving bias decisions to pursue drugs over other valuable, and healthier, alternatives in addiction? To address this question, we measured the in-the-moment economic decisions of people with opioid use disorder as they experienced craving, shortly after receiving their scheduled opioid maintenance medication and ~24 h later. We found that...
You, Zhi-Bing Galaj, Ewa Alén, Francisco Wang, Bin Bi, Guo-Hua Moore, Allamar R Buck, Tristram Crissman, Madeline Pari, Sruti Xi, Zheng-Xiong
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Published in
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Cocaine addiction is a significant medical and public concern. Despite decades of research effort, development of pharmacotherapy for cocaine use disorder remains largely unsuccessful. This may be partially due to insufficient understanding of the complex biological mechanisms involved in the pathophysiology of this disorder. In the present study, ...
Levis, Sophia C. Birnie, Matthew T. Bolton, Jessica L. Perrone, Christina R. Montesinos, Johanna S. Baram, Tallie Z. Mahler, Stephen V.
Published in
Translational Psychiatry
In humans, early-life adversity (ELA) such as trauma, poverty, and chaotic environment is linked to increased risk of later-life emotional disorders including depression and substance abuse. These disorders involve underlying disruption of reward circuits and likely vary by sex. Accordingly, we previously found that ELA leads to anhedonia for natur...
Visser, Esther Matos, Mariana R Mitrić, Miodrag M Kramvis, Ioannis van der Loo, Rolinka J Mansvelder, Huibert D Smit, August B van den Oever, Michel C
Published in
Biological psychiatry
Cocaine-associated environments (i.e., contexts) evoke persistent memories of cocaine reward and thereby contribute to the maintenance of addictive behavior in cocaine users. From a therapeutic perspective, enhancing inhibitory control over cocaine-conditioned responses is of pivotal importance but requires a more detailed understanding of the neur...
Joutsa, Juho Moussawi, Khaled Siddiqi, Shan H. Abdolahi, Amir Drew, William Cohen, Alexander L. Ross, Thomas J. Deshpande, Harshawardhan U. Wang, Henry Z. Bruss, Joel
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Published in
Nature Medicine
Lesions resulting in addiction remission occur in multiple different brain locations but map to a specific brain circuit.
Kinreich, Sivan
Published in
Translational Psychiatry
Li, Li Mamun, Mohammed A. Al-Mamun, Firoj Ullah, Irfan Hosen, Ismail Zia, Syed Ahsan Poorebrahim, Ali Pourgholami, Morteza Lin, Chung-Ying Pontes, Halley M.
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Published in
Current Psychology (New Brunswick, N.j.)
The Internet Disorder Scale–Short Form (IDS9-SF) is a validated instrument assessing internet disorder which modified the internet gaming disorder criteria proposed in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). However, the relationships between the nine items in the IDS9-SF are rarely investigated. The ...
Glegg, Stephanie McCrae, Karen Kolla, Gillian Touesnard, Natasha Turnbull, Jeffrey Brothers, Thomas D. Brar, Rupinder Sutherland, Christy Le Foll, Bernard Sereda, Andrea
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Published in
The International Journal on Drug Policy
Objectives In the context of the ongoing overdose crisis, a stark increase in toxic drug deaths from the unregulated street supply accompanied the onset of the COVID-19 pandemic. Injectable opioid agonist treatment (iOAT – hydromorphone or medical-grade heroin), tablet-based iOAT (TiOAT), and safer supply prescribing are emerging interventions used...
Das, Ravi K. Cawley, Emma A. Simeonov, Louise Piazza, Giulia Schmidt, Ulrike Wiers, Reinout W. H. J. Kamboj, Sunjeev K.
Published in
Scientific Reports
Binge eating is increasingly prevalent among adolescents and young adults and can have a lasting harmful impact on mental and physical health. Mechanistic insights suggest that aberrant reward-learning and biased cognitive processing may be involved in the aetiology of binge eating. We therefore investigated whether recently developed approaches to...
Siddiqui, Maaz Z Piserchio, John P Patel, Misha Park, Jino Foster, Michelle L Desrosiers, Clare E Herbert, John Nichols, Stephanie D McCall, Kenneth L Piper, Brian J
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Published in
Forensic science, medicine, and pathology
Much of the responsibility for the increasing drug overdoses in the US has been attributed to opioids but most opioid overdoses also involve another drug. The objective of this study was to identify the drugs involved in polysubstance arrests. The substances that were more likely to be found in conjunction with other substances, using the drug arre...
