Johnson, Andrew Habib, Shahid
Published in
Exploration of Digestive Diseases
With the rising prevalence of chronic liver disease worldwide, the incidence and prevalence of acute-on-chronic liver failure (ACLF) are increasing and attribute to higher morbidity, mortality, and healthcare costs. Many of such patients die without being considered for the lifesaving treatment option of liver transplantation. The underutilization ...
Sitbon, Alexandre Delmotte, Pierre-Romain Pistorio, Valéria Halter, Sébastien Gallet, Jérémy Gautheron, Jérémie Monsel, Antoine
Abstract Inflammation plays a critical role in conditions such as acute liver failure, acute-on-chronic liver failure, and ischemia–reperfusion-induced liver injury. Various pathogenic pathways contribute to liver inflammation, involving inflammatory polarization of macrophages and Küpffer cells, neutrophil infiltration, dysregulation of T cell sub...
Broekhoven, Annelotte G.C.; Ostyn, Tessa; 141245; van Melkebeke, Lukas; 141368; Verspaget, Hein W.; van der Merwe, Schalk; 71935; Verbeek, Jef; 74115; Coenraad, Minneke J.; 127095; Roskams, Tania A.; 7204; Nevens, Frederik; 14330;
OBJECTIVES: Alcoholic hepatitis (AH) is a frequent precipitating event for the development of acute-on-chronic liver failure (ACLF), a syndrome characterised by organ failures due to immune dysfunction. The histological features of this complication are not well characterized. We investigated whether ACLF has specific histological characteristics. ...
Jin, Pingbo Zhang, Wei Sun, Liying Lv, Haijin Duan, Xin Zhang, Yuntao Bai, Xueli Zhu, Zhijun Fung, John Liang, Tingbo
...
Published in
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
To designed a new model using pre-transplant data to predict post-transplant mortality for Chinese population and compared its performance to that of existing models. In this multicenter study, 544 recipients of liver transplants for non-tumor indications were enrolled in the training group and 276 patients in the validation group. The new Simplifi...
Zhang, Yu Tian, Xiao-Ling Li, Jie-Qun Wu, Dong-Sheng Li, Qiang Chen, Bin
Published in
World journal of gastroenterology
Immune dysregulation and metabolic derangement have been recognized as key factors that contribute to the progression of hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF). However, the mechanisms underlying immune and metabolic derangement in patients with advanced HBV-ACLF are unclear. To identify the bioenergetic alterations i...
Di Martino, Vincent Questiaux, Josselin Lemagoarou, Tristan Weil, Delphine Vendeville, Sophie Engelmann, Cornelius Hu, Jinhua Singh, Virendra Newsome, Philip N Lal, Sadhna B
...
Published in
Clinics and research in hepatology and gastroenterology
GCSF may improve the prognosis of severe liver disease by promoting liver regeneration and immune restoration. Our Aim was to investigate its controversial efficacy in decompensated cirrhosis, acute alcoholic hepatitis (AAH), or acute-on-chronic liver failure (ACLF) through meta-analysis. Meta-analysis of proportions (random effect model) including...
Li, Zhi-Hui Wang, Jun-Yi Li, Xian-Long Meng, Shi-Bo Zheng, Hui-Yuan Wang, Jia-Lei Lei, Zi-Ying Lin, Bing-Liang Zhang, Jing
Published in
Genomics
Acute-on-chronic liver failure (ACLF) is a major challenge in the field of hepatology. While mesenchymal stem cell (MSC) therapy can improve the prognosis of patients with ACLF, the molecular mechanisms through which MSCs attenuate ACLF remain poorly understood. We performed global miRNA and mRNA expression profiling via next-generation sequencing ...
Hartmann, Phillipp Lang, Sonja Schierwagen, Robert Klein, Sabine Praktiknjo, Michael Trebicka, Jonel Schnabl, Bernd
Published in
Hepatobiliary & pancreatic diseases international : HBPD INT
Cirrhosis with acute decompensation (AD) and acute-on-chronic liver failure (ACLF) are characterized by high morbidity and mortality. Cytolysin, a toxin from Enterococcus faecalis (E. faecalis), is associated with mortality in alcohol-associated hepatitis (AH). It is unclear whether cytolysin also contributes to disease severity in AD and ACLF. We ...
Wang, Xiao-Hao Peng, Bin-Bin Zhang, Lu Zhao, Jing Zhang, Li Ren, Hong Hu, Peng Li, Hu Zhong, Shan
Published in
Hepatology international
Different modes of artificial liver support (ALS) therapy can improve the survival of patients with acute-on-chronic liver failure (ACLF). This study aimed to compare the effects of mixed using different modes of ALS (MALS) and single using one mode of ALS (SALS) on 28- and 90-day survival rates of ACLF. Clinical data and survival times of patients...
Wei, Linlin Wang, Ting Chen, Sisi Liu, Yeying Huang, Xueying Zheng, Sujun Xu, Bin Ren, Feng Liu, Mei
Published in
Gut and liver
To investigate the autoantibody against fumarate hydratase (FH), which is a specific liver failure-associated antigen (LFAA) and determine whether it can be used as a biomarker to evaluate the prognosis of acute-on-chronic liver failure (ACLF). An immunoproteomic approach was applied to screen specific LFAAs related to differential prognosis of ACL...
