BACKGROUND/OBJECTIVES: The phase 3 REGAIN study and its open-label extension demonstrated the efficacy of the complement C5 inhibitor eculizumab in patients with treatment-refractory, acetylcholine receptor antibody-positive generalized myasthenia gravis (gMG). The aim of the ELEVATE study was to assess the effectiveness of eculizumab in clinical p...
Published in Annals of geriatric medicine and research
This study aimed to reveal differences in the effectiveness of rehabilitation in improving activities of daily living (ADL) in patients with acute stroke across age groups and propose age-appropriate rehabilitation strategies. This observational study analyzed nationwide administrative data of inpatients admitted to hospitals with acute stroke betw...
Published in European Neurology
Introduction: Mounting evidence indicates distinct memory profiles among the primary progressive aphasia (PPA) variants. Neuropsychological tests reveal disproportionate memory impairments in the logopenic variant PPA (lv-PPA) relative to the non-fluent variant PPA (nfv-PPA) and semantic variant PPA (sv-PPA). The real-world experience of day-to-day...
Published in Zeitschrift fur Gerontologie und Geriatrie
Dieser Fallbericht beschreibt einen 81-jährigen Patienten, der aufgrund akuter Visusminderung, Schwindel, allgemeiner Schwäche, Gangstörung und Sturzangst in eine Klinik für Augenheilkunde aufgenommen wurde. Zu den ophthalmologischen Befunden gehörten ein reperfundierter Arterienastverschluss links und eine Cataracta corticonuclearis provecta beids...
Published in The Clinical neuropsychologist
Objective: There is a crucial need for reliable tools to measure impaired self-awareness (ISA) in patients with acquired brain injury (ABI) across cognitive-functional domains. The aim of this study was to assess the psychometric properties of the Cog-Awareness ADL Scale, which is a novel self-proxy discrepancy method for measuring ISA in both basi...
Published in Neuromodulation : journal of the International Neuromodulation Society
This study aimed to determine agreement between reported percentage pain reduction (RPPR) and calculated percentage pain reduction (CPPR) in patients with percutaneous spinal cord stimulation (SCS) implants, and to correlate RPPR and CPPR with patient satisfaction. We also sought to determine which patient-reported outcome measures are most improve...
Published in Gerontology
Dementia is the largest single contributor to disability and need for care among older adults. Dementia is accompanied by a progressive decline in cognitive abilities that interferes with the performance of activities of daily living, including toileting. Caregivers rate the independent use of the toilet as the most important activity that they wou...
Examining how heat affects people with Parkinson’s disease is essential for informing clinical decision-making, safety, well-being, and healthcare planning. While there is evidence that the neuropathology associated with Parkinson’s disease affects thermoregulatory mechanisms, little attention has been given to the association of heat sensitivity t...
BACKGROUND AND PURPOSE: We compared the outcomes of endovascular therapy (EVT) in an extended time window in patients with large-vessel occlusion (LVO) between patients with and without pre-stroke disability. METHODS: In this prespecified analysis of the multinational CT for Late Endovascular Reperfusion study (66 participating sites, 10 countries ...
Published in Disability and rehabilitation. Assistive technology
Monitoring activities of daily living at home remains focused on using wearables to assess in-home functional mobility to support rehabilitation.Technologies remain a 4–6 readiness level and there is a lack of evidence to recommend in-home monitoring technologies.
