Development of low footprint processes with hazardous chemicals
Novel aqueous biphasic system based on ionic liquid for the simultaneous extraction of seven active pharmaceutical ingre...
Published in Environmental science and pollution research international
Nonsteroidal anti-inflammatory drugs and antibiotics are classes of active pharmaceutical ingredients (APIs), which are continuously contaminating the ecosystem through various anthropogenic activities. Because of their pseudo-persistence in the aquatic environment and their potentially chronic effects on aquatic life, it is important to closely mo...
Assistance of DFT calculations on the design and rationalization of active pharmaceutical ingredients synthesis - Michae...
Published in Tetrahedron
The Michael addition step and the following C5 isomerization in Hayashi's synthesis of Oseltamivir was studied by means of a DFT mechanistic study. These steps are crucial for the viability of the process where the formation of a single stereoisomer is required. The results indicate that the addition reaction is under thermodynamic and not kinetic ...
Recent applications of the Charged Aerosol Detector for liquid chromatography in drug quality control.
Published in Journal of chromatography. A
High performance liquid chromatography (HPLC) methods with UV/vis detection are the most widespread analytical procedures in modern pharmaceutical applications, but reach their limitations when it comes to non-chromophore molecules. Hence, instead of using tiresome derivatization procedures, many liquid chromatography methods make use of the so-cal...
Sustainable synthesis of uridine-5'-monophosphate analogues by immobilized uracil phosphoribosyltransferase from Thermus...
Published in Biochimica et biophysica acta. Proteins and proteomics
Nowadays enzymatic synthesis of nucleic acid derivatives is gaining momentum over traditional chemical synthetic processes. Biotransformations catalyzed by whole cells or enzymes offer an ecofriendly and efficient alternative to the traditional multistep chemical methods, avoiding the use of chemical reagents and organic solvents that are expensive...
From Lossen Transposition to Solventless “Medicinal Mechanochemistry”
An environmentally friendly mechanochemical strategy for the preparation of unsymmetrical ureas and 3,5-disubstituted hydantoins by using safe starting materials in place of hazardous and toxic isocyanates has been designed. For the first time, the Lossen rearrangement was successfully applied to prepare a collection of relevant structures in medic...
Deep eutectic solvents comprising active pharmaceutical ingredients in the development of drug delivery systems.
Published in Expert opinion on drug delivery
Deep eutectic solvents comprising or acting as solvents of active pharmaceutical ingredients (API-DES) emerged as promising alternatives to improve therapeutic efficiency, with the additional possibility to integrate them in (bio)polymer-based systems to enhance their delivery. A critical review of the API-DES field evolution is herein presented, n...
Tribo-electrification of pharmaceutical powder blends
It is well known in industrial applications involving powders and granular materials that the presence of electrostatic charges influences drastically the material flowing properties. The triboelectric charges are produced during flow at the contacts between the grains and at the contacts between the grains and the container. Unfortunately, the tri...
The Texture of Psychoactive Illicit Drugs in Iran: Adulteration with Lead and other Active Pharmaceutical Ingredients.
Published in Journal of psychoactive drugs
Psychoactive illicit drugs are widely used all over the world. Due to the high demand for illicit drugs, adulteration of substances with poisonous and active pharmaceutical ingredients is a common phenomenon in some countries. Lead and other active pharmaceutical ingredients are among adulterants added to illicit drugs intentionally. In the present...
Model evaluation for the prediction of solubility of active pharmaceutical ingredients (APIs) to guide solid–liquid sepa...
Published in Asian Journal of Pharmaceutical Sciences
The assumptions and models for solubility modelling or prediction in systems using non-polar solvents, or water and complex triterpene and other active pharmaceutical ingredients as solutes aren't well studied. Furthermore, the assumptions concerning heat capacity effects (negligibility, experimental values or approximations) are explored, using no...
