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MAIT Cells in Type 1 Diabetes Mouse Models

MAIT cells are unconventional T cells expressing a semi-invariant αβ TCR, and they recognize bacterial metabolites via the highly conserved MR1 protein. MAIT cells interact with gut microbiota and literature reports alterations of gut homeostasis in type 1 diabetes (T1D), suggesting the involvement of MAIT cells in T1D. Since NOD mice is a well-est...

Generation of low-energy neutrons cross-sections for the Monte Carlo code FLUKA and the deterministic code ActiWiz.

Published in Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

Activation of material is of interest for waste treatment and hazard assessment. In particular, activation of printed circuit can lead to the production of radionuclides at an isomeric state, for example, coming from silver. In particle accelerators, the production of silver isomeric states mainly come from low energy neutrons, below 20 MeV. The qu...

Rightward shift of optimal fascicle length with decreasing voluntary activity level in the soleus and lateral gastrocnem...

Published in The Journal of experimental biology

Much of our understanding of in vivo skeletal muscle properties is based on studies performed under maximal activation, which is problematic because muscles are rarely activated maximally during movements such as walking. Currently, force-length properties of the human triceps surae at submaximal voluntary muscle activity levels are not characteriz...

Insight into the improvement of dewatering performance of waste activated sludge and the corresponding mechanism by bioc...

Published in The Science of the total environment

A novel activator, corn biochar, was produced to activate persulfate to dewater waste activated sludge (WAS). Results demonstrated that the biochar-activated persulfate oxidation can effectively improve the dewatering performance of WAS. After treating WAS by biochar-activated persulfate oxidation (biochar dosage: 2.1 g/L, persulfate concentration:...

Citrullination as a novel posttranslational modification of matrix metalloproteinases.

Matrix metalloproteinases (MMPs) are enzymes with critical roles in biology and pathology. Glycosylation, nitrosylation and proteolysis are known posttranslational modifications (PTMs) regulating intrinsically the activities of MMPs. We discovered MMP citrullination by peptidyl arginine deiminases (PADs) as a new PTM. Upon hypercitrullination, MMP-...

The F1 loop of the talin head domain acts as a gatekeeper in integrin activation and clustering.

Published in Journal of cell science

Integrin activation and clustering by talin are early steps of cell adhesion. Membrane-bound talin head domain and kindlin bind to the β integrin cytoplasmic tail, cooperating to activate the heterodimeric integrin, and the talin head domain induces integrin clustering in the presence of Mn2+ Here we show that kindlin-1 can replace Mn2+ to mediate ...

Lower limb EMG activation during reduced gravity running on an incline. Speed matters more than hills irrespective of in...

Published in Gait & posture

Progressive loading of the lower limb muscles during running on a positive pressure or reduced gravity (Alter-G™) treadmill is suggested as a rehabilitation strategy after muscle and tendon injury but the influence of running up or downhill and at higher speeds is not known, nor are the interaction effects of speed, inclination, and indicated bodyw...

Intestinal Epithelial Expression of MHCII Determines Severity of Chemical, T-Cell-Induced, and Infectious Colitis in Mic...

Published in Gastroenterology

Intestinal epithelial cells (IECs) provide a barrier that separates the mucosal immune system from the luminal microbiota. IECs constitutively express low levels of major histocompatibility complex (MHC) class II proteins, which are upregulated upon exposure to interferon gamma. We investigated the effects of deleting MHCII proteins specifically in...