Muddobalaiah, Prabha Ravi, Vasanthapuram Thammanna, Chethan Chandagalu Sagar, Bhadravathi Kenchappa Chandrasekh... Swamy, Narayana Swamy Ramachandra
Published in
Journal of chemical neuroanatomy
Acid Phosphatase (ACP) and Alkaline Phosphatases (ALP) are hydrolases that remove phosphate groups from protein and nucleic acid respectively for regulation of cell function from ACP as lysosomal defence function and ALP membrane-bound as a barrier of the cell. The ACP and ALP-specific activities of Meningiomas (n = 75) and gliomas (n = 81) were co...
Mao, Zhiyuan Nesterenko, Pavlo A McLaughlin, Jami Deng, Weixian Sojo, Giselle Burton Cheng, Donghui Noguchi, Miyako Chour, William DeLucia, Diana C Finton, Kathryn A
...
Tissue-specific antigens can serve as targets for adoptive T cell transfer-based cancer immunotherapy. Recognition of tumor by T cells is mediated by interaction between peptide-major histocompatibility complexes (pMHCs) and T cell receptors (TCRs). Revealing the identity of peptides bound to MHC is critical in discovering cognate TCRs and predicti...
Zhang, Li Kandadi, Harini Yang, Hai Cham, Jason He, Tao Oh, David Y Sheikh, Nadeem A Fong, Lawrence
Sipuleucel-T is an autologous cellular immunotherapy, administered as three infusions, for metastatic castration-resistant prostate cancer (mCRPC). Sipuleucel-T induces T- and B-cell responses to prostatic acid phosphatase (PAP), correlating to improved survival. The long-term impact of sipuleucel-T on tumor antigen-specific immunologic memory rema...
Weil, Tatjana Groß, Rüdiger Röcker, Annika Bravo-Rodriguez, Kenny Heid, Christian Sowislok, Andrea Le, My-Hue Erwin, Nelli Dwivedi, Mridula M., Stephen
...
Broad-spectrum antivirals are powerful weapons against dangerous viruses where no specific therapy exists, as in the case of the ongoing SARS-CoV-2 pandemic. We discovered that a lysine- and arginine-specific supramolecular ligand (CLR01) destroys enveloped viruses, including HIV, Ebola, and Zika virus, and remodels amyloid fibrils in semen that pr...
Vazquez, Sara E Ferré, Elise Mn Scheel, David W Sunshine, Sara Miao, Brenda Mandel-Brehm, Caleigh Quandt, Zoe Chan, Alice Y Cheng, Mickie German, Michael
...
The identification of autoantigens remains a critical challenge for understanding and treating autoimmune diseases. Autoimmune polyendocrine syndrome type 1 (APS1), a rare monogenic form of autoimmunity, presents as widespread autoimmunity with T and B cell responses to multiple organs. Importantly, autoantibody discovery in APS1 can illuminate fun...
McNeel, Douglas G Eickhoff, Jens C Johnson, Laura E Roth, Alison R Perk, Timothy G Fong, Lawrence Antonarakis, Emmanuel S Wargowski, Ellen Jeraj, Robert Liu, Glenn
...
PurposeWe previously reported the safety and immunologic effects of a DNA vaccine (pTVG-HP [MVI-816]) encoding prostatic acid phosphatase (PAP) in patients with recurrent, nonmetastatic prostate cancer. The current trial evaluated the effects of this vaccine on metastatic progression.Patients and methodsNinety-nine patients with castration-sensitiv...
Pudney, Alex Gandini, Chiara Economou, Chloe K Smith, Richard Goddard, Paul Napier, Johnathan A Spicer, Andrew Sayanova, Olga
There is an urgent requirement for sustainable sources of food and feed due to world population growth. Aquaculture relies heavily on the fish meal and fish oils derived from capture fisheries, challenging sustainability of the production system. Furthermore, substitution of fish oil with vegetable oil and fish meal with plant seed meals in aquacul...
Jing, Yao Zhang, Lin Xu, Zhiming Chen, Hao Ju, Shiming Ding, Jun Guo, Yan Tian, Hengli
Published in
Medical science monitor : international medical journal of experimental and clinical research
BACKGROUND The phosphatase actin regulator-1 (PHACTR-1) gene on chromosome 6 encodes an actin and protein phosphatase 1 (PP1) binding protein, Phactr-1, which is highly expressed in brain tissues. Phactr-1 expression is involved in physiological and pathological cerebral microvascular events. This study aimed to investigate the role of expression o...
Toal, Ted W Ron, Mily Gibson, Donald Kajala, Kaisa Splitt, Bessie Johnson, Logan S Miller, Nathan D Slovak, Radka Gaudinier, Allison Patel, Rohan
...
Regulation of plant root angle is critical for obtaining nutrients and water and is an important trait for plant breeding. A plant's final, long-term root angle is the net result of a complex series of decisions made by a root tip in response to changes in nutrient availability, impediments, the gravity vector and other stimuli. When a root tip is ...
D’Arena, Giovanni Musto, Pellegrino
Published in
Indian Journal of Hematology and Blood Transfusion
