Xia, Mengfan Liu, Tongtong Zhang, Yaodong
Published in
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry
A colorimetric method for detection of acetylcholinesterase (AChE) activity and inhibition was developed using metal organic frameworks (i.e., PCN-222(Fe)) with peroxidase-like activity. The blue tetramethylbenzidine oxidized by PCN-222(Fe) fades due to the reduction by acetylthiocholine chloride produced from AChE catalysis. The detection method s...
Charlie-Silva, Ives Araújo, Amanda P.C. Guimarães, Abraão T.B. Veras, Flávio P. Braz, Helyson L.B. de Pontes, Letícia G. Jorge, Roberta J.B. Belo, Marco A.A. Fernandes, Bianca H.V. Nóbrega, Rafael H.
...
Published in
Journal of Hazardous Materials
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Godfrey, Donald A Carlson, Lissette Park, Jami L Ross, C David
Published in
Brain research
Although there is strong evidence for cholinergic projections to the rat inferior colliculus, especially from the pedunculopontine tegmental nucleus (Noftz et al., 2020), there is a lack of information about the quantitative prevalence of the enzymes of acetylcholine metabolism in its various portions. We have used microdissection of freeze-dried s...
Mezeiova, Eva Hrabinova, Martina Hepnarova, Vendula Jun, Daniel Janockova, Jana Muckova, Lubica Prchal, Lukas Kristofikova, Zdena Kucera, Tomas Gorecki, Lukas
...
Published in
Bioorganic & medicinal chemistry letters
The search for novel and effective therapeutics for Alzheimer's disease (AD) is the main quest that remains to be resolved. The goal is to find a disease-modifying agent able to confront the multifactorial nature of the disease positively. Herewith, a family of huprineY-tryptophan heterodimers was prepared, resulting in inhibition of cholinesterase...
Gürdere, Meliha Burcu Budak, Yakup Kocyigit, Umit M. Taslimi, Parham Tüzün, Burak Ceylan, Mustafa
Published in
In Silico Pharmacology
In this study, in vitro inhibition effects of (E)-1-(4-aminophenyl)-3-(aryl) prop-2-en-1-one (4-amino-chalcones) derivatives (3a–o) on acetylcholinesterase (AChE) enzyme and human erythrocyte carbonic anhydrase I and II isoenzymes (hCA I- II) were investigated. And also, the biological activities of 4-amino-chalcone derivatives against enzymes whic...
Yan, Bingsong Liu, Wendong Duan, Guangbin Ni, Pengjuan Jiang, Yuanyuan Zhang, Chenghui Wang, Bo Lu, Yizhong Chen, Chuanxia
Published in
Microchimica Acta
A convenient and sensitive colorimetric assay for acetylcholinesterase (AChE) and its inhibitor has been designed based on the oxidase-like activity of {100}-faceted Pd square nanoplates which are grown in situ on reduced graphene oxide ([email protected]). [email protected] can effectively catalyze the oxidation of colorless 3,3′,5,5′-tetramethylbenzidine (TMB) wit...
Ahmed, Mushtaq Khan, Shahan Zeb Sher, Naila Rehman, Zia Ur Mushtaq, Nadia Khan, Rahmat Ali
Published in
The Journal of Venomous Animals and Toxins Including Tropical Diseases
Background: The venom of the krait ( Bungarus sindanus ), an Elapidae snake, is highly toxic to humans and contains a great amount of acetylcholinesterase (AChE). The enzyme AChE provokes the hydrolysis of substrate acetylcholine (ACh) in the nervous system and terminates nerve impulse. Different inhibitors inactivate AChE and lead to ACh accumulat...
Mathew, Bijo Oh, Jong Min Baty, Roua S. Batiha, Gaber El-Saber Parambi, Della Grace Thomas Gambacorta, Nicola Nicolotti, Orazio Kim, Hoon
Published in
Environmental Science and Pollution Research International
Eleven piperazine-containing 1,3-diphenylprop-2-en-1-one derivatives ( PC1-PC11 ) were evaluated for their inhibitory activities against monoamine oxidases (MAOs), cholinesterases (ChEs), and β-site amyloid precursor protein cleaving enzyme 1 (BACE-1) with a view toward developing new treatments for neurological disorders. Compounds PC10 and PC11 r...
Khurana, Kunal Kumar, Manish Bansal, Nitin
Published in
Neurotoxicity research
Cholinergic deficits and oxido-nitrosative stress are consistently associated with Alzheimer's disease (AD). Previous findings indicate that acetylcholine subdues Ca2+ current in the brain. Cholinergic antagonists (e.g., scopolamine) can instigate Ca2+-induced redox imbalance, inflammation, and cell-death pathways leading to AD-type memory impairme...
Johnson, Titilayo Omolara Abolaji, Amos Olalekan Omale, Simeon Longdet, Ishaya Yohanna Kutshik, Richard Joseph Oyetayo, Bolaji Oyenike Adegboyega, Abayomi Emmanuel Sagay, Atiene
Published in
Toxicology Reports
Benzo[a]pyrene (B[a]P) is a polycyclic aromatic hydrocarbon (PAH) commonly found in cigarette smoke, automobile exhaust fumes, grilled meat, and smoked food among others. Exposure to B[a]P is associated with a range of toxic effects including developmental, neurological, oxidative, inflammatory, mutagenic, carcinogenic and mortal. Efficient and mor...
