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Sandborn, William J; Cyrille, Marcoli; Hansen, Mark Berner; Feagan, Brian G; Loftus, Edward V; Rogler, Gerhard; Vermeire, Severine; 3938; Cruz, Martha L; Yang, Jun; Boedigheimer, Michael J;
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BACKGROUND & AIMS: The α4β7 integrin is a validated target in inflammatory bowel disease. This randomized, phase 2b, placebo-controlled, double-blind study evaluated the efficacy and safety of the anti-α4β7 antibody abrilumab in patients with moderate-to-severe ulcerative colitis despite treatment with conventional therapies. METHODS: Patients (tot...
Hibi, Toshifumi Motoya, Satoshi Ashida, Toshifumi Sai, Souken Sameshima, Yukinori Nakamura, Shiro Maemoto, Atsuo Nii, Masahiro Sullivan, Barbara A Gasser Jr, Robert A.
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Published in
Intestinal Research
Background/Aims Inhibition of α4β7 integrin has been shown to be effective for induction and maintenance therapy in patients with ulcerative colitis (UC). We investigated the effects of varying doses of the α4β7 inhibitor abrilumab in Japanese patients with moderate-to-severe UC despite conventional treatments. Methods In this randomized, double-bl...
