Chen, Xuan-Yu Wu, Zhuo-Xun Wang, Jing-Quan Teng, Qiu-Xu Tang, Hailin Liu, Qianwen Chen, Zhe-Sheng Chen, Wenkuan
Published in
Frontiers in Pharmacology
The therapeutic effect of chemotherapy and targeted therapy are known to be limited by drug resistance. Substantial evidence has shown that ATP-binding cassette (ABC) transporters P-gp and BCRP are significant contributors to multidrug resistance (MDR) in cancer cells. In this study, we demonstrated that a clinical-staged ATR inhibitor ceralasertib...
Zhang, Zi-Jie Zhou, Yi Tong, Huan Sun, Xi-Cheng Lv, Zi-Cheng Yong, June-Kong Wu, Yi-Chi Xiang, Xue-Lin Ding, Fei Zuo, Xiao-Lei
...
Published in
Advanced healthcare materials
Surgical residual tumor lesions (R1 resection of surgical procedures (e.g., liver cancer infiltrating the diaphragm, surgical residual breast cancer, postoperative residual ovarian cancer) or boundary residual after ablation) and lymph node metastasis that cannot be surgically resected (retroperitoneal lymph nodes) significantly affect postoperativ...
Mavroeidi, Dimitra Georganta, Anastasia Panagiotou, Emmanouil Syrigos, Konstantinos Souliotis, Vassilis L
Published in
International journal of molecular sciences
The DNA damage response (DDR) system is a complicated network of signaling pathways that detects and repairs DNA damage or induces apoptosis. Critical regulators of the DDR network include the DNA damage kinases ataxia telangiectasia mutated Rad3-related kinase (ATR) and ataxia-telangiectasia mutated (ATM). The ATR pathway coordinates processes suc...
Park, Sohee Choi, Changhoon Kim, Haeyoung Shin, Yong Jae Oh, Yunjeong Park, Won Cho, Won Kyung Kim, Nalee
Published in
Breast cancer research and treatment
This study aimed to compare the radiosensitizing effect of the PARP inhibitor, Olaparib, between proton and X-rays irradiations in BRCA-proficient breast cancer (BC) cells. Two BRCA-proficient BC cell lines, MDA-MB-231 and T47D BC, were used. Cell proliferation was assessed using the CCK-8 assay, and radiosensitivity was determined through the clon...
Gong, Liuyun Lu, Yinliang Wang, Jing Li, Xinyue Zhao, Jing Chen, Yuetong Ma, Rongze Ma, Jinlu Liu, Tianya Han, Suxia
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Published in
Journal of pharmaceutical analysis
Intensive cancer treatment with drug combination is widely exploited in the clinic but suffers from inconsistent pharmacokinetics among different therapeutic agents. To overcome it, the emerging nanomedicine offers an unparalleled opportunity for encapsulating multiple drugs in a nano-carrier. Herein, a two-step super-assembled strategy was perform...
Sundararajan, Vignesh Tan, Tuan Zea Lim, Diana Peng, Yanfen Wengner, Antje Margret Ngoi, Natalie Yan Li Jeyasekharan, Anand D Tan, David Shao Peng
Published in
The Journal of pathology
Excessive genomic instability coupled with abnormalities in DNA repair pathways induces high levels of 'replication stress' when cancer cells propagate. Rather than hampering cancer cell proliferation, novel treatment strategies are turning their attention towards targeting cell cycle checkpoint kinases (such as ATR, CHK1, WEE1, and others) along t...
Harata, Shinnosuke Suzuki, Takuya Takahashi, Hiroki Hirokawa, Takahisa Kato, Akira Watanabe, Kaori Yanagita, Takeshi Ushigome, Hajime Shiga, Kazuyoshi Ogawa, Ryo
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Published in
Oncology Reports
Ataxia telangiectasia and Rad3-related (ATR) is a kinase that repairs DNA damage. Although inhibitors that selectively target ATR have been developed, their effectiveness in colorectal cancer has not been widely reported. The present study hypothesized that anticancer agents that effectively act in the S phase before the G2/M checkpoint may be idea...
Rogalska, Aneta
Olaparib is a PARP inhibitor (PARPi) approved for targeted treatment of ovarian cancer (OC). However, its efficacy is impeded by the inevitable occurrence of resistance. This study investigated whether the cytotoxic activity of olaparib could be synergistically enhanced in olaparib-resistant OC cells with BRCA2 reversion mutation by the addition of...
Hauge, Sissel Eek Mariampillai, Adrian Rødland, Gro Elise Bay, Lilli T E Landsverk, Helga B Syljuåsen, Randi G
Published in
International journal of radiation biology
Radiation-induced activation of cell cycle checkpoints have been of long-standing interest. The WEE1, CHK1 and ATR kinases are key factors in cell cycle checkpoint regulation and are essential for the S and G2 checkpoints. Here, we review the rationale for why inhibitors of WEE1, CHK1 and ATR could be beneficial in combination with radiation. Combi...
Pan, You Yang, Yuchao Huang, Rong Yang, Huawei Huang, Qinghua Ji, Yinan Dai, Jingxing Qiao, Kun Tang, Wei Xie, Longgui
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Published in
Breast Cancer Research : BCR
Background/aims This study explores the relationship between the E3 ubiquitin ligase Ring finger protein 126 (RNF126) and early breast cancer metastasis and tests the hypothesis that RNF126 determines the efficacy of inhibitors targeting Ataxia telangiectasia mutated and Rad3-related kinase (ATR). Methods Various metastasis-related genes were ident...
