Scheper, Julian Hildebrand, Laura S Faulhaber, Eva-Maria Deloch, Lisa Gaipl, Udo S Symank, Julia Fietkau, Rainer Distel, Luitpold V Hecht, Markus Jost, Tina
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Published in
Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]
Despite new treatment options, melanoma continues to have an unfavorable prognosis. DNA damage response (DDR) inhibitors are a promising drug class, especially in combination with chemotherapy (CT) or radiotherapy (RT). Manipulating DNA damage repair during RT is an opportunity to exploit the genomic instability of cancer cells and may lead to radi...
Xie, Kangling Li, Cui Wang, Mingzhu Fu, Siqian Cai, Ying
Published in
Frontiers in Endocrinology
Objective Diabetes pathology relies on exosomes (Exos). This study investigated how peripheral blood Exo-containing microRNAs (miRNAs) cause vascular injury in type 2 diabetes (T2D). Methods We removed DEmiRNA from T2D chip data from the GEO database. We isolated Exo from 15 peripheral blood samples from T2D patients and 15 healthy controls and mea...
Colombo, Mara Mondini, Patrizia Minenza, Elisa Foglia, Claudia Mosconi, Annamaria Molica, Carmen Pistola, Lorenza Ludovini, Vienna Radice, Paolo
Published in
Frontiers in Oncology
Gambín Sánchez, Nuria
[ES] El objetivo principal de este trabajo final de grado es investigar, diseñar y analizar la estructura de un cajero automático con el propósito de garantizar su accesibilidad y usabilidad, promoviendo la inclusión y el acceso igualitario. Durante el desarrollo del proyecto, se aplican las metodologías adecuadas para alcanzar la solución más apro...
Narsaiah, M.N. Lasya, Gangalam Veronica, Kondamudi Abhilash, Kirthana, Padaga Sravya Kumari, M. Santoshi Pathani, Ashish
Published in
E3S Web of Conferences
Today, it is typical to need to identify and validate a person in order to use a safe box, operate a vehicle, access a bank account via an ATM, or carry out other operations that call for the protection of personal information. The accuracy and dependability of traditional methods, such as ID card verification or signature, are lacking. The systems...
Kiweler, Nicole Schwarz, Helena Nguyen, Alexandra Matschos, Stephanie Mullins, Christina Piée-Staffa, Andrea Brachetti, Christina Roos, Wynand P Schneider, Günter Linnebacher, Michael
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Published in
Cell biology and toxicology
The epigenetic modifier histone deacetylase-2 (HDAC2) is frequently dysregulated in colon cancer cells. Microsatellite instability (MSI), an unfaithful replication of DNA at nucleotide repeats, occurs in about 15% of human colon tumors. MSI promotes a genetic frameshift and consequently a loss of HDAC2 in up to 43% of these tumors. We show that lon...
Abdel-Razeq, Hikmat
Published in
Frontiers in Oncology
Breast cancer continues to be the most common cancer diagnosed among women worldwide. Family history of breast cancer is frequently encountered, and 5-15% of patients may carry inherited pathogenic germline variants, identification of which can be helpful for both; patients themselves and their unaffected close relatives. The availability and affor...
Lin, Po-Han Tien, Yun-Wen Cheng, Wen-Fang Chiang, Ying-Cheng Wu, Chien-Huei Yang, Karen Huang, Chiun-Sheng
Published in
Journal of gynecologic oncology
Genetic high-risk assessment combines hereditary breast, ovarian and pancreatic cancer into one syndrome. However, there is a lack of data for comparing the germline mutational spectrum of the cancer predisposing genes between these three cancers. Patients who met the criteria of the hereditary breast, ovarian and pancreatic cancer were enrolled an...
Hwang, Mihwa Jun, Dong Wha Song, Bo Ram Shim, Hanna Lee, Chang-Hun Kim, Sunshin
Published in
Biomolecules & therapeutics
Ataxia-telangiectasia mutated (ATM), a master kinase of the DNA damage response (DDR), phosphorylates a multitude of substrates to activate signaling pathways after DNA double-strand breaks (DSBs). ATM inhibitors have been evaluated as anticancer drugs to potentiate the cytotoxicity of DNA damage-based cancer therapy. ATM is also involved in autoph...
Paranal, Raymond M Jiang, Zhengdong Hutchings, Danielle Kryklyva, Valentyna Gauthier, Christian Fujikura, Kohei Nanda, Neha Huang, Bo Skaro, Michael Wolfgang, Christopher L
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Published in
The Journal of pathology
Understanding the timing and spectrum of genetic alterations that contribute to the development of pancreatic cancer is essential for effective interventions and treatments. The aim of this study was to characterize somatic ATM alterations in noninvasive pancreatic precursor lesions and invasive pancreatic adenocarcinomas from patients with and wit...
