Fu, Xiao Duan, Zhongchao Lu, Xin Zhu, Yingyu Ren, Yuanyuan Zhang, Wei Sun, Xiaoming Ge, Lin Yang, Jie
Published in
Cancer biotherapy & radiopharmaceuticals
Background: Radiotherapy is one of the most effective therapeutic strategies for cervical cancer patients, although radioresistance-mediated residual and recurrent tumors are the main cause of treatment failure. However, the mechanism of tumor radioresistance is still elusive. DNA damage response pathways are key determinants of radioresistance. Th...
Zhang, Chencheng Liu, Jibin Wu, Jun Ranjan, Kamakshi Cui, Xiaopeng Wang, Xingdan Zhang, Dianzheng Zhu, Shudong
Published in
Frontiers in Cell and Developmental Biology
Our understanding of the DNA damage responses of human cells to radiation has increased remarkably over the recent years although some notable signaling events remain to be discovered. Here we provide a brief account of the key molecular events of the responses to reflect the current understanding of the key underlying mechanisms involved.
Stevenson, Louise K. Page, Amy J. Dowson, Matthew ElBadry, Sameh K. Barnieh, Francis M. Falconer, Robert A. El-Khamisy, Sherif F.
Published in
Frontiers in Cell and Developmental Biology
Classically, ATM is known for its role in sensing double-strand DNA breaks, and subsequently signaling for their repair. Non-canonical roles of ATM include transcriptional silencing, ferroptosis, autophagy and angiogenesis. Angiogenesis mediated by ATM signaling has been shown to be VEGF-independent via p38 signaling. Independently, p38 signaling h...
Ammous-Boukhris, Nihel Abdelmaksoud-Dammak, Rania Ben Ayed-Guerfali, Dorra Guidara, Souhir Jallouli, Olfa Kamoun, Hassen Charfi Triki, Chahnez Mokdad-Gargouri, Raja
Published in
Frontiers in Neurology
Ataxia-telangiectasia (A-T) is an autosomal recessive primary immunodeficiency disorder (PID) caused by biallelic mutations occurring in the serine/threonine protein kinase (ATM) gene. The major role of nuclear ATM is the coordination of cell signaling pathways in response to DNA double-strand breaks, oxidative stress, and cell cycle checkpoints. D...
Evteev, Sergei Ivanenkov, Yan Semenov, Ivan Malkov, Maxim Mazaleva, Olga Bodunov, Artem Bezrukov, Dmitry Sidorenko, Denis Terentiev, Victor Malyshev, Alex
...
Published in
Frontiers in Chemistry
Introduction: The significance of automated drug design using virtual generative models has steadily grown in recent years. While deep learning-driven solutions have received growing attention, only a few modern AI-assisted generative chemistry platforms have demonstrated the ability to produce valuable structures. At the same time, virtual fragmen...
Chen, Phang-Lang Chen, Chi-Fen Lin, Hugo Y-H Riley, Daniel J Chen, Yumay
Published in
International journal of molecular sciences
In autosomal dominant polycystic kidney disease (ADPKD) with germline mutations in a PKD1 or PKD2 gene, innumerable cysts develop from tubules, and renal function deteriorates. Second-hit somatic mutations and renal tubular epithelial (RTE) cell death are crucial features of cyst initiation and disease progression. Here, we use established RTE line...
Chen, Chi-Fen Lin, Hugo Riley, Daniel Chen, Yumay Chen, Phang-Lang
In autosomal dominant polycystic kidney disease (ADPKD) with germline mutations in a PKD1 or PKD2 gene, innumerable cysts develop from tubules, and renal function deteriorates. Second-hit somatic mutations and renal tubular epithelial (RTE) cell death are crucial features of cyst initiation and disease progression. Here, we use established RTE line...
Prasad, Anjali Kanakkanthara, Arun
Published in
Trends in cell biology
How chromatin configuration impacts DNA repair is an emerging question. A recent study by Arnould et al. shows that ATM orchestrates a new chromatin compartment (D compartment) following DNA double-strand breaks and establishes that this compartment enhances cellular response to such breaks but also introduces a risk to genome integrity. Copyright ...
Vijaywargiya, Yamini Mishra, Mahak Doohan, Nitika Vats
Published in
Journal of Automation, Mobile Robotics and Intelligent Systems
We propose a Computer Vision and Machine Learning equipped model that secures the ATM from fraudulent activities by leveraging the use of Haar cascade (HRC) and Local Binary Pattern Histogram (LBPH) classifier for face detection and recognition correspondingly, which in turn detect fraud by utilizing features, like PIN and face recognition, help to...
Lendinez-Sanchez, Gonzalo Diaz-Redondo, Tamara Iglesias Campos, Marcos Porta Pelayo, Javier Porta Pelayo, José María Muriel-López, Carolina
Published in
Case Reports in Oncology
Introduction: Ataxia-Telangiectasia Mutated (ATM) is a cancer predisposition gene; carriers of germline pathogenic variants have an increased risk of developing malignancies, including breast, prostate, pancreatic, and ovarian cancer. Most ATM variants are of uncertain significance. Findings from genome-wide association studies (GWAS) suggest that ...
