Ebrahimpur, Mahbube Sharifi, Farshad Shadman, Zhaleh Payab, Moloud Mehraban, Saghar Shafiee, Gita Heshmat, Ramin Fahimfar, Noushin Mehrdad, Neda Khashayar, Patricia
...
Published in
Archives of Osteoporosis
SummaryCognitive impairment and osteoporosis are frequently seen to coincide in clinical practice. Osteoporosis was higher in elderly populations with cognitive impairment, especially in postmenopausal women. Thus, prophylaxis for osteoporosis, falls, and fractures should be considered as part of the treatment of patients with cognitive impairment....
Todd, Evelyn T; Thomson, Peter C; Hamilton, Natasha A; Ang, Rachel A; Lindgren, Gabriella; 120649; Viklund, Asa; Eriksson, Susanne; Mikko, Sofia; Strand, Eric; Velie, Brandon D;
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Domestic animal populations are often characterised by high rates of inbreeding and low effective population sizes due to selective breeding practices. These practices can result in otherwise rare recessive deleterious alleles drifting to high frequencies, resulting in reduced fertility rates. This study aimed to identify potential recessive lethal...
Smith, Benjamin A. Gelles, Jeff Goode, Bruce L.
Published in
Methods in Enzymology
The actin cytoskeleton is very dynamic and highly regulated by multiple associated proteins in vivo. Understanding how this system of proteins functions in the processes of actin network assembly and disassembly requires methods to dissect the mechanisms of activity of individual factors and of multiple factors acting in concert. The advent of sing...
Ghosh, Manosij; 95907; Janssen, Lisa; 120515; Martens, Dries; Öner, Deniz; Vlaanderen, Jelle; Pronk, Anjoeka; Kuijpers, Eelco; Vermeulen, Roel; Nawrot, Tim; Godderis, Lode; 5874;
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Carbon nanotubes (CNTs) – except MWCNT-7 - have been classified as Group 3 [ “Not classifiable as to its carcinogenicity to humans”] by the IARC. Despite considerable mechanistic evidence in vitro/ in vivo, the classification highlights a general lack of data, especially among humans. In our previous study, we reported epigenetic changes in the MWC...
Devreese, Katrien M.J. Linskens, Eleni A. Benoit, Dominique Peperstraete, Harlinde
Published in
Journal of Thrombosis and Haemostasis
Background High incidence of thrombosis in COVID‐19 patients indicates a hypercoagulable state. Hence, exploring the involvement of antiphospholipid antibodies (aPL) in these patients is of interest. Objectives To illustrate the incidence of criteria (lupus anticoagulant (LAC), anticardiolipin (aCL) IgG/IgM, antibeta2‐glycoprotein I antibodies (aβ2...
Janssens, Birgit; Caerels, Simon; Mathieu, Chantal; 9139;
Even before sodium-glucose cotransporter inhibitors (SGLTi) became popular agents for the treatment of people with type 2 diabetes (T2DM), clinicians had explored their potential as adjunct therapies in type 1 diabetes (T1DM). Several trials have demonstrated improved glycemic control (compared with placebo) and a decrease in glucose variability wi...
Vangoitsenhoven, Roman; 85333; Wilson, Rickesha; Sharma, Gautam; Punchai, Suriya; Corcelles, Ricard; Froylich, Dvir; Mulya, Anny; Schauer, Philip R; Brethauer, Stacy A; Kirwan, John P;
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BACKGROUND: Metabolic surgery has beneficial metabolic effects, including remission of type 2 diabetes. We hypothesized that duodenojejunal bypass (DJB) surgery can protect against development of type 1 diabetes (T1D) by enhancing regulation of cellular and molecular pathways that control glucose homeostasis. METHODS: BBDP/Wor rats, which are prone...
Sirunyan, AM Tumasyan, A Adam, W Ambrogi, F Bergauer, T Dragicevic, M Ero, J Del Valle, AE Flechl, M Fruhwirth, R
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Measurements of the cross section for the production of top quark pairs in association with a pair of jets from bottom quarks (σtt¯bb¯¯¯) and in association with a pair of jets from quarks of any flavor or gluons (σtt¯jj) and their ratio are presented. The data were collected in proton-proton collisions at a center-of-mass energy of 13 TeV by the C...
Ngabonziza, Jean Claude Semuto; Loiseau, Chloe; Marceau, Michael; Jouet, Agathe; Menardo, Fabrizio; Tzfadia, Oren; Antoine, Rudy; Niyigena, Esdras Belamo; Mulders, Wim; Fissette, Kristina;
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The human- and animal-adapted lineages of the Mycobacterium tuberculosis complex (MTBC) are thought to have expanded from a common progenitor in Africa. However, the molecular events that accompanied this emergence remain largely unknown. Here, we describe two MTBC strains isolated from patients with multidrug resistant tuberculosis, representing a...
Dreesen, Erwin; 64069; Berends, Sophie; Laharie, David; D'Haens, Geert; Vermeire, Severine; 3938; Gils, Ann; Mathot, Ron;
AIMS: Evidence for the benefits of pharmacokinetic (PK) and pharmacodynamic (PD) monitoring of infliximab in patients with Crohn's disease (CD) remains scarce. We aimed to develop a population (pop)PK/PD model to characterise the infliximab dose-exposure-biomarker-response (faecal calprotectin [fCal] and endoscopic remission [ER]) relationship. MET...
