Les viroïdes, vestiges du monde ARN à la frontière du vivant ?
International audience
Homologous chromosome pairing in meiosis of higher eukaryotes-still an enigma?
Published in Genome
Meiosis is the basis of the generative reproduction of eukaryotes. The crucial first step is homologous chromosome pairing. In higher eukaryotes, micrometer-scale chromosomes, micrometer distances apart, are brought together by nanometer DNA sequences, at least a factor of 1000 size difference. Models of homology search, homologue movement, and pai...
Covid 19: du microbiote à l'azithromycine, mythes et réalités / Covid 19: from microbiote to azithromycin, myths and rea...
Impact of double-stranded RNA characteristics on the activation of human 2'-5'-oligoadenylate synthetase 2 (OAS2).
Published in Biochemistry and cell biology = Biochimie et biologie cellulaire
Human 2'-5' oligoadenylate synthetases (OAS) are a family of interferon-inducible proteins that, upon activation by double-stranded RNA, polymerize ATP into 2'-5' linked oligoadenylates. In this study, we probed the RNA cofactor specificity of the two smallest isozymes, OAS1 and OAS2. First, we developed a strategy for the expression and purificati...
¿Cómo entender información especializada del COVID-19?
Resumen Esta hoja didáctica acompaña al artículo titulado El origen de COVID-19: lo que se sabe, lo que se supone y (muy poquito) sobre las teorías de complot. La idea es conducir a los estudiantes en la lectura, haciendo uso de palabras y conceptos que pueden reconocer o que podemos hacer que recuerden. Los alumnos y las alumnas harán modelos senc...
Molecular detection of 7SL-derived small RNA is a promising alternative for trypanosomosis diagnosis
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Equine trypanosomosis comprises different parasitic diseases caused by protozoa of the subgenus Trypanozoon : Trypanosoma equiperdum (causative agent of dourine), Trypanosoma brucei (nagana) and Trypanosoma evansi (surra). Due to the absence of a vaccine and the lack of efficacy of the few available drugs, these diseases represent a major health an...
Post-transcriptional regulation of several biological processes involved in latex production in Hevea brasiliensis
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Background: Small RNAs modulate plant gene expression at both the transcriptional and post-transcriptional level, mostly through the induction of either targeted DNA methylation or transcript cleavage, respectively. Small RNA networks are involved in specific plant developmental processes, in signaling pathways triggered by various abiotic stresses...
Structural and functional annotation of transposable elements revealed a potential regulation of genes involved in rubbe...
The natural rubber biosynthetic pathway is well described in Hevea, although the final stages of rubber elongation are still poorly understood. Small Rubber Particle Proteins and Rubber Elongation Factors (SRPPs and REFs) are proteins with major function in rubber particle formation and stabilization. Their corresponding genes are clustered on a sc...
Un modelo didáctico para comprender la estructura y mecanismos de acción de los virus y su relación con el desarrollo de...
Resumen Se presenta la construcción de un modelo simple de virus y del proceso de salto antigénico por rearreglo genético que apoye a la comprensión de aspectos relevantes sobre la aparición de virus como el SARS-CoV-2 y los posibles cambios que se llevan a cabo en ellos a través de modelos, argumentación y planteamiento de un modelo explicativo. S...
Gene expression in coffee
Coffee is cultivated in more than 70 countries of the intertropical belt where it has important economic, social and environmental impacts. As for many other crops, the development of molecular biology technics allowed to launch research projects for coffee analyzing gene expression. In the 90s decade, the first expression studies were performed by...
