Trougakos, Ioannis P. Stamatelopoulos, Kimon Terpos, Evangelos Tsitsilonis, Ourania E. Aivalioti, Evmorfia Paraskevis, Dimitrios Kastritis, Efstathios Pavlakis, George N. Dimopoulos, Meletios A.
Published in
Journal of Biomedical Science
BackgroundGaining further insights into SARS-CoV-2 routes of infection and the underlying pathobiology of COVID-19 will support the design of rational treatments targeting the life cycle of the virus and/or the adverse effects (e.g., multi-organ collapse) that are triggered by COVID-19-mediated adult respiratory distress syndrome (ARDS) and/or othe...
Majumder, Joydeb Minko, Tamara
Published in
The AAPS Journal
The ongoing pandemic of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has made a serious public health threat worldwide with millions of people at risk in a growing number of countries. Though there are no clinically approved antiviral drugs and vaccines for COVID-19, attempts are ong...
Contou, Damien Fraissé, Megan Pajot, Olivier Tirolien, Jo-Anna Mentec, Hervé Plantefève, Gaëtan
Published in
Critical Care
Seeliger, Benjamin Döbler, Michael Friedrich, Robert Stahl, Klaus Kühn, Christian Bauersachs, Johann Steinhagen, Folkert Ehrentraut, Stefan F. Schewe, Jens-Christian Putensen, Christian
...
Published in
Critical Care
BackgroundExtracorporeal membrane oxygenation (ECMO) support in acute respiratory failure may be lifesaving, but bleeding and thromboembolic complications are common. The optimal anticoagulation strategy balancing these factors remains to be determined. This retrospective study compared two institutional anticoagulation management strategies focuss...
Loganathan, Sundareswaran Kuppusamy, Maheshkumar Wankhar, Wankupar Gurugubelli, Krishna Rao Mahadevappa, Vidyashree Hodagatta Lepcha, Lhakit Choudhary, Arbind Kumar
Published in
Respiratory physiology & neurobiology
Globally, the current medical emergency for novel coronavirus 2019 (COVID-19) leads to respiratory distress syndrome and death. This review highlighted the effect of COVID-19 on systemic multiple organ failure syndromes. This review is intended to fill a gap in information about human physiological response to COVID-19 infections. This review may s...
Medar, Shivanand S Villacres, Sindy Kaushik, Shubhi Eisenberg, Ruth Stone, Melvin E Jr
Published in
Journal of intensive care medicine
There is paucity of data about prevalence of pediatric acute respiratory distress syndrome (PARDS) in children with pulmonary contusion (PC). We intend to evaluate PC in children with chest trauma and the association between PC and PARDS. Retrospective review of Institutional Trauma Registry for patients with trauma. Level 1 trauma center. Age 18 y...
Molotkov, Andrei Bhatt, Nikunj Doubrovin, Mikhail Castrillon, John Massa, Christopher Gerber, Adam D’Armiento, Jeanine Goldklang, Monica Mintz, Akiva
Published in
Molecular Biomedicine
Inflammatory changes caused by viruses, bacteria, exposure to toxins, commonly used drugs and even surgical intervention have the potential of causing abnormal epithelial permeability, which is manifest as infiltrative processes on computed tomography (CT), including the widespread infiltrates seen in COVID-19 pneumonia and acute respiratory distre...
Juschten, Jenny Ingelse, Sarah A. Bos, Lieuwe D. J. Girbes, Armand R. J. Juffermans, Nicole P. van der Poll, Tom Schultz, Marcus J. Tuinman, Pieter Roel de Beer, F. M. Bos, L. D.
...
Published in
Intensive Care Medicine Experimental
BackgroundAlkaline phosphatase (AP), a dephosphorylating enzyme, is involved in various physiological processes and has been shown to have anti-inflammatory effects.AimTo determine the correlation between pulmonary AP activity and markers of inflammation in invasively ventilated critically ill patients with or without acute respiratory distress syn...
Scharffenberg, Martin Wittenstein, Jakob Herzog, Moritz Tauer, Sebastian Vivona, Luigi Theilen, Raphael Bluth, Thomas Kiss, Thomas Koch, Thea Fiorentino, Giuseppe
...
Published in
Intensive Care Medicine Experimental
BackgroundContinuous external negative pressure (CENP) during positive pressure ventilation can recruit dependent lung regions. We hypothesised that CENP applied regionally to the thorax or the abdomen only, increases the caudal end-expiratory transpulmonary pressure depending on positive end-expiratory pressure (PEEP) in lung-injured pigs. Eight p...
Razazi, Keyvan Arrestier, Romain Haudebourg, Anne Fleur Benelli, Brice Carteaux, Guillaume Decousser, Jean‑Winoc Fourati, Slim Woerther, Paul Louis Schlemmer, Frederic Charles-Nelson, Anais
...
Published in
Critical Care
BackgroundData on incidence of ventilator-associated pneumonia (VAP) and invasive pulmonary aspergillosis in patients with severe SARS-CoV-2 infection are limited.MethodsWe conducted a monocenter retrospective study comparing the incidence of VAP and invasive aspergillosis between patients with COVID-19-related acute respiratory distress syndrome (...
