Ariens, Robert Becattini, Cecilia Bender, Markus Bergmeier, Wolfgang Castoldi, Elisabetta Devreese, Katrien Ellis, Martin Gailani, David Ignjatovic, Vera James, Paula D
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Published in
Research and practice in thrombosis and haemostasis
The 2020 Congress of the International Society of Thrombosis and Haemostasis (ISTH) was held virtually July 12-15, 2019, due to the coronavirus disease 2019 pandemic. The congress convenes annually to discuss clinical and basic topics in hemostasis and thrombosis. Each year, the program includes State of Art (SOA) lectures given by prominent scient...
Devreese, Katrien de Groot, Philip G. de Laat, Bas Erkan, Doruk Favaloro, Emmanuel J. Mackie, Ian Martinuzzo, Marta Ortel, Thomas L. Pengo, Vittorio Rand, Jacob H.
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This guidance focuses on methodological aspects of lupus anticoagulant (LA) testing, as well as interpretation of results for clinicians. The main changes in how to test for LA compared with the International Society on Thrombosis and Haemostasis Scientific and Standardization Committee 2009 guidelines, in the preanalytical phase are more detailed ...
Ruiz-Limon, Patricia; Ortega-Castro, Rafaela; Barbarroja, Nuria; Perez-Sanchez, Carlos; Jamin, Christophe; Maria Patino-Trives, Alejandra; Luque-Tevar, Maria; Ibanez-Costa, Alejandro; Perez-Sanchez, Laura; Arias de la Rosa, Ivan;
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Objectives: This study, developed within the Innovative Medicines Initiative Joint Undertaking project PRECISESADS framework, aimed at functionally characterize the monocyte subsets in RA patients, and analyze their involvement in the increased CV risk associated with RA. Methods: The frequencies of monocyte subpopulations in the peripheral blood o...
Chayoua, Walid Kelchtermans, Hilde Moore, Gary Gris, Jean-Christophe Musial, Jacek Wahl, Denis Zuily, Stéphane Gianniello, Francesca Fontana, Pierre Remijn, Jasper
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The anti-phospholipid syndrome (APS) is characterized by thrombosis and/or pregnancy morbidity with persistent presence of anti-phospholipid antibodies (aPL). Laboratory criteria include aPL detection by coagulation tests for lupus anticoagulant (LAC) or solid phase assays measuring anti-β2 glycoprotein I (aβ2GPI) or anti-cardiolipin (aCL) immunogl...
Canti, Valentina Del Rosso, Stefania Tonello, Marta Lucianò, Roberta Hoxha, Ariela Coletto, Lavinia A Vaglio Tessitore, Isadora Rosa, Susanna Manfredi, Angelo A Castiglioni, Maria Teresa
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Published in
The Journal of rheumatology
Antibodies that recognize the phosphatidylserine/prothrombin complex (antiphosphatidylserine/prothrombin antibodies; aPS/PT) might reveal enhanced thrombotic risk in patients with systemic lupus erythematosus. Little is known about their association with pregnancy complications in the antiphospholipid syndrome (APS). We enrolled 55 patients with AP...
Yue, Cai Li, Guanhong Wen, Yubing Li, Xuemei Gao, Ruitong
Published in
The Journal of rheumatology
To investigate the renal protective effects of early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN). Medical data of 57 SLE patients with biopsy-proven aPLN were analyzed. Early RAAS blockade was d...
Wu, Jiayue Ma, Jinghang Bao, Chunde Di, Wen Zhang, Wei Hong
Objective: To completely and quantifiably determine the effect of systemic lupus erythematosus (SLE) on pregnancy outcomes in a Chinese cohort. Design: A retrospective cohort study. Setting: Data were collected at a tertiary medical centre located in Shanghai, China, from September 2011 to May 2017. Participants: We assigned 338 pregnant women with...
Wiles, Kate Lightstone, Liz
Published in
Kidney international reports
Gender differences exist in the prevalence of glomerular diseases. Data based on histological diagnosis underestimate the prevalence of preeclampsia, which is almost certainly the commonest glomerular disease in the world, and uniquely gender-specific. Glomerular disease affects fertility via disease activity, the therapeutic use of cyclophosphamid...
Zohoury, Navid Bertolaccini, Maria Laura Rodriguez-Garcia, Jose Luis Shums, Zakera Ateka-Barrutia, Oier Sorice, Maurizio Norman, Gary L Khamashta, Munther
Published in
The Journal of rheumatology
Most clinicians use the 2006 Sydney classification criteria to evaluate patients suspected of having antiphospholipid syndrome (APS). Although sensitive and specific for APS, many patients fulfilling clinical criteria for the syndrome are persistently negative for the specific serological tests ("laboratory criteria"). These "seronegative APS" (SN-...
Tripodi, A Chantarangkul, V Cini, M Devreese, K Dlott, J S Giacomello, R Gray, E Legnani, C Martinuzzo, M E Pradella, P
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Published in
Journal of thrombosis and haemostasis : JTH
Essentials Between-lab variations of cut-off values in lupus anticoagulant detection are unknown. Cut-off values were calculated in 11 labs each testing plasma from 120 donors with 3 platforms. Major variation was observed even within the same platform. Cut-off values determined in different labs are not interchangeable. Background Cut-off values f...
