Jian, Yanlin Merceron, Romain De Munck, Steven Forbes, He Eun Hulpia, Fabian Risseeuw, Martijn D P Van Hecke, Kristof Savvides, Savvas N Munier-Lehmann, Hélène Boshoff, Helena I M
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Published in
European journal of medicinal chemistry
As the last enzyme in nucleotide synthesis as precursors for DNA replication, thymidylate kinase of M. tuberculosis (MtbTMPK) attracts significant interest as a target in the discovery of new anti-tuberculosis agents. Earlier, we discovered potent MtbTMPK inhibitors, but these generally suffered from poor antimycobacterial activity, which we hypoth...
Pertusati, Fabrizio; Pileggi, Elisa; Richards, Jennifer; Wootton, Mandy; Van Leemputte, Thijs; 135272; Persoons, Leentje; De Coster, David; Villanueva, Xabier; 115967; Daelemans, Dirk; 18154; Steenackers, Hans; 54330;
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OBJECTIVES: Following a drug repurposing approach, we aimed to investigate and compare the antibacterial and antibiofilm activities of different classes of phosphate prodrugs (HepDirect, cycloSal, SATE and mix SATE) of antiviral and anticancer FDA-approved nucleoside drugs [zidovudine (AZT), floxouridine (FUDR) and gemcitabine (GEM)] against a vari...
Tie, Yaxin; 100484; Duchateau, Celine; Van de Steene, Shana; Mees, Corenthin; De Braekeleer, Kris; De Beer, Thomas; Adams, Erwin; 2122; Deconinck, Eric;
The threats of substandard and falsified (SF) antimicrobials, posed to public health, include serious adverse drug effects, treatment failures and even development of antimicrobial resistance. Next to these issues, it has no doubt that efficient methods for on-site screening are required to avoid that SF antimicrobials reach the patient or even inf...
Davies, Jonathan A; Bull, Freya M; Walker, Paul D; Weir, Angus NM; Lavigne, Rob; 24787; Masschelein, Joleen; 59443; Simpson, Thomas J; Race, Paul R; Crump, Matthew P; Willis, Christine L;
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The kalimantacins make up a family of hybrid polyketide-nonribosomal peptide-derived natural products that display potent and selective antibiotic activity against multidrug resistant strains of Staphylococcus aureus. Herein, we report the first total synthesis of kalimantacin A, in which three fragments are prepared and then united via Sonogashira...
Bereczki, Ilona; Csavas, Magdolna; Szucs, Zsolt; Roth, Erzsebet; Batta, Gyula; Ostorhazi, Eszter; Naesens, Lieve; 13761; Borbas, Aniko; Herczegh, Pal;
The limited scope of antiviral drugs and increasing problem of antiviral drug resistance represent a global health threat. Glycopeptide antibiotics and their lipophilic derivatives have emerged as relevant inhibitors of diverse viruses. Herein, we describe a new strategy for the synthesis of dual hydrophobic and lipophobic derivatives of glycopepti...
Oni, Feyisara E. Geudens, Niels Adiobo, Amayana Omoboye, Olumide O. Enow, Elsie A. Onyeka, Joseph T. Salami, Ayodeji E. De Mot, René Martins, José C. Höfte, Monica
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Published in
Microorganisms
Pseudomonas cyclic lipopeptides (CLPs) are encoded non-ribosomally by biosynthetic gene clusters (BGCs) and possess diverse biological activities. In this study, we conducted chemical structure and BGC analyses with antimicrobial activity assays for two CLPs produced by Pseudomonas strains isolated from the cocoyam rhizosphere in Cameroon and Niger...
McBeath, ST Wilkinson, DP Graham, NJD
Emerging electrochemical systems, such as advanced electro-oxidation, provide a potentially powerful alternative to conventional oxidation processes which can often be unsuitable for small, remote and decentralised system applications. The one electro-oxidation process, which may be well suited for these applications, is the use of high oxygen over...
Oni, Feyisara E; Geudens, Niels; Adiobo, Amayana; Omoboye, Olumide O; Enow, Elsie A; Onyeka, Joseph T; Salami, Ayodeji E; De Mot, Rene; 8980; Martins, Jose C; Hofte, Monica;
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Pseudomonas cyclic lipopeptides (CLPs) are encoded non-ribosomally by biosynthetic gene clusters (BGCs) and possess diverse biological activities. In this study, we conducted chemical structure and BGC analyses with antimicrobial activity assays for two CLPs produced by Pseudomonas strains isolated from the cocoyam rhizosphere in Cameroon and Niger...
Mohseni, Mojtaba Postacchini, Pietro Demeestere, Kristof Du Laing, Gijs Yüce, Süleyman Wessling, Matthias
Published in
Journal of hazardous materials
Dal, Nils-Jørgen Knudsen Kocere, Agnese Wohlmann, Jens Van Herck, Simon Bauer, Tobias A Resseguier, Julien Bagherifam, Shahla Hyldmo, Hilde Barz, Matthias De Geest, Bruno G
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Published in
Small (Weinheim an der Bergstrasse, Germany)
The zebrafish embryo is a vertebrate well suited for visualizing nanoparticles at high resolution in live animals. Its optical transparency and genetic versatility allow noninvasive, real-time observations of vascular flow of nanoparticles and their interactions with cells throughout the body. As a consequence, this system enables the acquisition o...
