Jackson, J Jambrina, E Li, J Marston, H Menzies, F Phillips, K Gilmour, G
Dynamic gain and loss of synapses is fundamental to healthy brain function. While Alzheimer’s Disease (AD) treatment strategies have largely focussed on beta-amyloid and tau protein pathologies, the synapse itself may also be a critical endpoint to consider regarding disease modification. Disruption of mechanisms of neuronal plasticity, eventually ...
Li, Shukun Zou, Qianli Xing, Ruirui Govindaraju, Thimmaiah Fakhrullin, Rawil Yan, Xuehai
Advances in supramolecular self-assembly have promoted the development of theranostics, the combination of both therapeutic and diagnostic functions in a single nanoplatform, which is closely associated with antitumor applications and has shown promising potential in personalized medicine. Peptide-modulated self-assembly serves as a versatile strat...
Detrez, Jan R Maurin, Hervé Van Kolen, Kristof Willems, Roland Colombelli, Julien Lechat, Benoit Roucourt, Bart Van Leuven, Fred Baatout, Sarah Larsen, Peter
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We have exploited whole brain microscopy to map the progressive deposition of hyperphosphorylated tau in intact, cleared mouse brain. We found that the three-dimensional spreading pattern of hyperphosphorylated tau in the brain of an aging Tau.P301L mouse model did not resemble that observed in AD patients. Injection of synthetic or patient-derived...
Li, Shukun Zou, Qianli Xing, Ruirui Govindaraju, Thimmaiah Fakhrullin, Rawil Yan, Xuehai
Advances in supramolecular self-assembly have promoted the development of theranostics, the combination of both therapeutic and diagnostic functions in a single nanoplatform, which is closely associated with antitumor applications and has shown promising potential in personalized medicine. Peptide-modulated self-assembly serves as a versatile strat...
Voet, Sofie Srinivasan, Sahana Lamkanfi, Mohamed van Loo, Geert
Neuroinflammation and neurodegeneration often result from the aberrant deposition of aggregated host proteins, including amyloid-beta, alpha-synuclein, and prions, that can activate inflammasomes. Inflammasomes function as intracellular sensors of both microbial pathogens and foreign as well as host-derived danger signals. Upon activation, they ind...
KHATRIL, A PUNJABI, N GHOSH, D MAJI, SK MUKHERJI, S
alpha-Synuclein protein, whose aggregation is associated with Parkinson's disease, is detected using a compact, label-free, localized surface plasmon resonance (LSPR) based optical sensor. U-shaped fiber optic probe immobilized with gold nanoparticles (GNP), and subsequently functionalized using a film of chitosan was used as a sensing platform. Th...
De Roeck, Arne Duchateau, Lena Van Dongen, Jasper Cacace, Rita Bjerke, Maria Van den Bossche, Tobi Cras, Patrick Vandenberghe, Rik De Deyn, Peter P Engelborghs, Sebastiaan
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Mutations leading to premature termination codons in ATP-Binding Cassette Subfamily A Member 7 (ABCA7) are high penetrant risk factors of Alzheimer's disease (AD). The influence of other genetic variants in ABCA7 and downstream functional mechanisms, however, is poorly understood. To address this knowledge gap, we investigated tandem repetitive reg...
Verstraelen, Peter Van Dyck, Michiel Verschuuren, Marlies Kashikar, Nachiket D Nuydens, Rony Timmermans, Jean-Pierre De Vos, Winnok
Neurological disorders display a broad spectrum of clinical manifestations. Yet, at the cellular level, virtually all these diseases converge into a common phenotype of dysregulated synaptic connectivity. In dementia, synapse dysfunction precedes neurodegeneration and cognitive impairment by several years, making the synapse a crucial entry point f...
McInnes, Joseph Wierda, Keimpe Snellinx, An Bounti, Laura Wang, Yu-Chun Stancu, Ilie-Cosmin Apóstolo, Nuno Gevaert, Kris Dewachter, Ilse Spires-Jones, Tara L
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Synaptic dysfunction is an early pathological feature of neurodegenerative diseases associated with Tau, including Alzheimer's disease. Interfering with early synaptic dysfunction may be therapeutically beneficial to prevent cognitive decline and disease progression, but the mechanisms underlying synaptic defects associated with Tau are unclear. In...
Zhang, Yang-xin Wang, Shao-wei Lu, Shuai Zhang, Ling-xiao Liu, Dong-qun Ji, Mei Wang, Wei-yun Liu, Rui-tian
Beta-amyloid (A beta) oligomers are strongly associated with the cascade of harmful events leading to neurodegeneration in Alzheimer's disease (AD). Elimination of A beta oligomers or inhibition of A beta assembly is a valuable therapeutic approach for the treatment of AD. Here, we obtained a mimotope of A beta oligomers, AOEP2, by screening a pep...