Liu, Jui-Ming Liu, Shing-Hwa Fu, Shih-Chang Lai, Wei-Cheng Fang, Kai-Min Lin, Ken-An Ke, Jun-An Kuo, Chun-Ying Su, Chin-Chuan Chen, Ya-Wen
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Published in
Toxicology
Tetrabromobisphenol A (TBBPA), a brominated flame retardant (BFR), has been implicated as the neurotoxic effects in mammalian. However, the exact mechanisms underlying TBBPA-induced neurotoxicity remain unclear. In the present study, Neuro-2a cells, a mouse neural crest-derived cell line, were used to examine the mechanism of TBBPA-induced neuronal...
liu, yi yinfen, xu huilin, ji gao, fenfen ruoting, ge zhou, dan hengyi, fu liu, xiaodong shumei, ma
Radiation liver injury is a common complication of hepatocellular carcinoma radiotherapy. It is mainly caused by irreversible damage to the DNA of hepatocellular cells directly by radiation, which seriously interferes with metabolism and causes cell death. AdipoRon can maintain lipid metabolism and stabilize blood sugar by activating adiponectin re...
Mushajiang, Mayibai Li, Yalan Sun, Zhen Liu, Jia Zhang, Lili Wang, Zhongqun
Published in
Cellular signalling
Vascular calcification (VC) is a characteristic feature in patients with diabetes mellitus (DM) and is closely associated with the osteogenic differentiation of vascular smooth muscle cells (VSMCs). Ubiquitin-Specific Protease 10 (USP10) has been shown to regulate multiple cellular processes; however, its relationship with diabetic VC remains uncle...
Peng, Yuce Guo, Mingyu Luo, Minghao Lv, Dingyi Liao, Ke Luo, Suxin Zhang, Bingyu
Published in
Heliyon
Dapagliflozin (DAPA) has been demonstrated to reduce cardiovascular mortality and heart failure hospitalization rates in diabetic patients. However, the mechanism underlying its cardio-protective effect in non-diabetic patients remains unclear. Our study aimed to explore the cardio-protective impact of DAPA on myocardial infarction in non-diabetic ...
Choudhury, Debanik Rong, Na Senthil Kumar, Hamsa Vardini Swedick, Sydney Samuel, Ronel Z Mehrotra, Pihu Toftegaard, John Rajabian, Nika Thiyagarajan, Ramkumar Podder, Ashis K
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Published in
Cell reports
Mitochondrial dysfunction is a hallmark of cellular senescence, with the loss of mitochondrial function identified as a potential causal factor contributing to senescence-associated decline in cellular functions. Our recent findings revealed that ectopic expression of the pluripotency transcription factor NANOG rejuvenates dysfunctional mitochondri...
Babu, Vishnu Suresh Mallipatna, Ashwin Dudeja, Gagan Shetty, Rohit Nair, Archana Padmanabhan Tun, Sai Bo Bo Ho, Candice Ee Hua Chaurasia, Shyam S. Bhattacharya, Shomi S. Verma, Navin Kumar
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Lack of retinoblastoma (Rb) protein causes aggressive intraocular retinal tumors in children. Recently, Rb tumors have been shown to have a distinctly altered metabolic phenotype, such as reduced expression of glycolytic pathway proteins alongside altered pyruvate and fatty acid levels. In this study, we demonstrate that loss of hexokinase 1(HK1) i...
Babu, Vishnu Suresh Mallipatna, Ashwin Dudeja, Gagan Shetty, Rohit Nair, Archana Padmanabhan Tun, Sai Bo Bo Ho, Candice Ee Hua Chaurasia, Shyam S Bhattacharya, Shomi S Verma, Navin Kumar
...
Published in
Translational research : the journal of laboratory and clinical medicine
Lack of retinoblastoma (Rb) protein causes aggressive intraocular retinal tumors in children. Recently, Rb tumors have been shown to have a distinctly altered metabolic phenotype, such as reduced expression of glycolytic pathway proteins alongside altered pyruvate and fatty acid levels. In this study, we demonstrate that loss of hexokinase 1(HK1) i...
Liang, Hui Liu, Gaoli Fan, Qinglu Nie, Zhihao Xie, Songping Zhang, Renquan
Published in
International immunopharmacology
AMP-activated protein kinase (AMPK) activation plays crucial roles in the treatment of many oxidative stress- and inflammation-induced diseases, including acute lung injury (ALI). Limonin is a naturally occurring tetracyclic triterpenoid extracted from the plants of Rutaceae and Meliaceae. Limonin also serves as an AMPK activator with anti-inflamma...
ting, li tan, qi wei, chunli zou, hui liu, xiaoyan mei, zhiqiang zhang, pengfei cheng, jingliang junjiang, fu
TQFL12 is a novel derivative designed and synthesized on the basis of Thymoquinone (TQ) which is extracted from Nigella sativa seeds. We have demonstrated that TQFL12 was more effective in the treatment of TNBC than TQ. In order to directly reflect the acute toxicity of TQFL12 in vivo, in this study, we designed, synthesized, and compared it with T...
jinhai, yu guoliang, hu guo, xiaoquan cao, huabin zhang, caiying
Energy deficiency causes multiple organ dysfunctions after LPS induction. Quercetin is a phenolic compound found in herbal medicines. However, the effects of quercetin in alleviating LPS-induced energy deficiency remain unclear. In the present study, an in vivo LPS-induced inflammation model was established in chicken embryos. Specific pathogen-fre...