Papp, Mariusz Gruca, Piotr Lason, Magdalena Litwa, Ewa Solecki, Wojciech Willner, Paul
Published in
Journal of psychopharmacology (Oxford, England)
The chronic mild stress (CMS) procedure is a widely used animal model of depression, and its application in Wistar-Kyoto (WKY) rats has been validated as a model of antidepressant-refractory depression. While not responding to chronic treatment with antidepressant drugs, WKY rats do respond to acute deep brain stimulation (DBS) of the medial prefro...
Ueda, Daiki Yonemochi, Naomi Kamata, Tomohiro Shibasaki, Masahiro Kamei, Junzo Waddington, John L Ikeda, Hiroko
Published in
British journal of pharmacology
Patients with diabetes mellitus are reported to show a raised prevalence of mental disorders, which may be reflected in impaired social interaction. However, the mechanisms underlying such impairment in diabetes are unknown. The present study investigated whether social interaction is impaired in diabetic mice and whether central neuropeptide Y (NP...
Gerace, Elisabetta Ilari, Alice Caffino, Lucia Buonvicino, Daniela Lana, Daniele Ugolini, Filippo Resta, Francesco Nosi, Daniele Grazia Giovannini, Maria Ciccocioppo, Roberto
...
Published in
Journal of neurochemistry
Modifications in the subunit composition of AMPA receptors (AMPARs) have been linked to the transition from physiological to pathological conditions in a number of contexts, including EtOH-induced neurotoxicity. Previous work from our laboratory showed that EtOH withdrawal causes CA1 pyramidal cell death in organotypic hippocampal slices and change...
Martín-Belmonte, Alejandro Aguado, Carolina Alfaro-Ruíz, Rocío Itakura, Makoto Moreno-Martínez, Ana Esther de la Ossa, Luis Molnár, Elek Fukazawa, Yugo Luján, Rafael
Published in
Frontiers in Aging Neuroscience
Synapse loss occurs early in Alzheimer’s disease (AD) patients and animal models. Alterations at synaptic level are a major morphological correlate of the memory deficits and related symptoms of AD. Given the predominant roles of synaptic AMPA receptors (AMPARs) in excitatory synaptic transmission in the brain, changes in their dynamic regulation a...
Widagdo, Jocelyn Kerk, Jun Wei Guntupalli, Sumasri Huganir, Richard L Anggono, Victor
Published in
Cellular and molecular neurobiology
Excitatory neurotransmission relies on the precise targeting of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors to the neuronal plasma membrane. Activity-dependent ubiquitination of AMPA receptor (AMPAR) subunits sorts internalised receptors to late endosomes for degradation, which ultimately determines the numb...
Kwak, Dong Gyu Lee, Dong Gyu
Published in
Annals of rehabilitation medicine
To investigate the glial cell and AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor activity after surgery for disc herniation pain model. In total, 83 Sprague-Dawley rats were randomly assigned to the following groups: control (n=16), sham-operated (n=4), rats for pain behavior evaluation (n=3), nucleus pulposus-exposed grou...
Yang, Ya-Chin Wang, Guan-Hsun Chuang, Ai-Yu Hsueh, Shu-Wei
Published in
British journal of pharmacology
Perampanel is a newly approved anticonvulsant uniquely targeting AMPA receptors, which mediate the most abundant form of excitatory synaptic transmission in the brain. However, the network mechanism underlying the anti-epileptic effect of the AMPAergic inhibition remains to be explored. The mechanism of perampanel action was studied with the basola...
Darvish-Ghane, Soroush Quintana, Clémentine Beaulieu, Jean-Martin Martin, Loren J.
Published in
Molecular Brain
The release of dopamine (DA) into target brain areas is considered an essential event for the modulation of many physiological effects. While the anterior cingulate cortex (ACC) has been implicated in pain related behavioral processes, DA modulation of synaptic transmission within the ACC and pain related phenotypes remains unclear. Here we charact...
Levite, Mia Zelig, Daniel Friedman, Alon Ilouz, Nili Eilam, Raya Bromberg, Zohar Ramadhan Lasu, Ally Ahmed Arbel-Alon, Sagit Edvardson, Shimon Tarshish, Mark
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Published in
Journal of autoimmunity
Nodding Syndrome (NS) is a fatal pediatric epilepsy of unknown etiology, accompanied by multiple neurological impairments, and associated with Onchocerca volvulus (Ov), malnutrition, war-induced trauma, and other insults. NS patients have neuroinflammation, and ~50% have cross-reactive Ov/Leiomodin-1 neurotoxic autoimmune antibodies. RESULTS: Study...
Sladek, Asia L. Nawy, Scott
Published in
Frontiers in Synaptic Neuroscience
AMPA-type glutamate receptors in the CNS are normally impermeable to Ca2+, but the aberrant expression of Ca2+-permeable AMPA receptors (CP-AMPARs) occurs in pathological conditions such as ischemia or epilepsy, or degenerative diseases such as ALS. Here, we show that select populations of retinal ganglion cells (RGCs) similarly express high levels...
