Kluin-Nelemans, Hanneke C; Jawhar, Mohamad; Reiter, Andreas; van Anrooij, Bjorn; Gotlib, Jason; Hartmann, Karin; Illerhaus, Anja; Elberink, Hanneke NG Oude; Gorska, Aleksandra; Niedoszytko, Marek;
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In systemic mastocytosis (SM), the clinical features and survival vary greatly. Patient-related factors determining the outcome in SM are largely unknown. Methods: We examined the impact of sex on the clinical features, progression-free survival (PFS), and overall survival (OS) in 3403 patients with mastocytosis collected in the registry of the Eur...
Londoño Agudelo, Esteban García Fariñas, Anaí Pérez Ospina, Viviana Taborda Pérez, Cecilia Villacrés Landeta, Tatiana Battaglioli, Tullia Gómez Arias, Rubén Van der Stuyft, Patrick
Published in
Global health action
Background Hypertension requires life-long medical care, which may cause economic burden and even lead to catastrophic health expenditure. Objective To estimate the extent of out-of-pocket expenditure for hypertension care at a population level and its impact on households' budgets in a low-income urban setting in Colombia. Methods We conducted a c...
Dickson, Kayle Malitan, Hajer Lehmann, Christian
Published in
Biology
Because of its unique microvascular anatomy, the intestine is particularly vulnerable to microcirculatory disturbances. During inflammation, pathological changes in blood flow, vessel integrity and capillary density result in impaired tissue oxygenation. In severe cases, these changes can progress to multiorgan failure and possibly death. Microcirc...
Muiño-Mosquera, Laura De Wilde, Hans Devos, Daniel Babin, Danilo Jordaens, Luc Demolder, Anthony De Groote, Katya De Wolf, Daniel De Backer, Julie
Published in
Orphanet Journal of Rare Diseases
BackgroundAortic root dilatation and—dissection and mitral valve prolapse are established cardiovascular manifestations in Marfan syndrome (MFS). Heart failure and arrhythmic sudden cardiac death have emerged as additional causes of morbidity and mortality.MethodsTo characterize myocardial dysfunction and arrhythmia in MFS we conducted a prospectiv...
Declercq, D Huysentruyt, K Hauser, B De Wachter, E Van Daele, S De Baets, F Van Biervliet, S
Published in
European journal of clinical nutrition
Enteral tube feeding (ETF) is often used in an attempt to optimize the nutritional status. The aim of this study was to observe the long term effect of ETF and to compare the start of ETF with the current European guidelines on nutrition care in CF. From all patients who received ETF (ETFp) between February 2000 and September 2016 in the Ghent Univ...
Saldien, Vera; Schepens, Tom; Vanlinthout, Luc; 87959; Wildemeersch, Davina; Wouters, Kristien; Vercauteren, Marcel; Menovsky, Tomas;
BACKGROUND: Rapid ventricular pacing (RVP) can be used to produce short periods of flow arrest during dissection or rupture of a cerebral aneurysm but carries the risk of inducing cerebral ischemia. This study evaluates the intraoperative effect of RVP on local cerebral blood flow (CBF) and cerebral oxygenation during neurovascular surgery. MATERIA...
Firth, Joseph; Solmi, Marco; Wootton, Robyn E; Vancampfort, Davy; 60570; Schuch, Felipe B; Hoare, Erin; Gilbody, Simon; Torous, John; Teasdale, Scott B; Jackson, Sarah E;
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There is increasing academic and clinical interest in how "lifestyle factors" traditionally associated with physical health may also relate to mental health and psychological well-being. In response, international and national health bodies are producing guidelines to address health behaviors in the prevention and treatment of mental illness. Howev...
Steijns, Felke Renard, Marjolijn Vanhomwegen, Marine Vermassen, Petra Desloovere, Jana Raedt, Robrecht Larsen, Lars E Tóth, Máté I De Backer, Julie Sips, Patrick
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Published in
International journal of molecular sciences
Patients with Marfan syndrome (MFS), a connective tissue disorder caused by pathogenic variants in the gene encoding the extracellular matrix protein fibrillin-1, have an increased prevalence of primary cardiomyopathy, arrhythmias, and sudden cardiac death. We have performed an in-depth in vivo and ex vivo study of the cardiac phenotype of Fbn1mgR/...
Tona, Risa Lopez, Ivan A Fenollar-Ferrer, Cristina Faridi, Rabia Anselmi, Claudio Khan, Asma A Shahzad, Mohsin Morell, Robert J Gu, Shoujun Hoa, Michael
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Published in
Genes
Human pathogenic variants of TBC1D24 are associated with clinically heterogeneous phenotypes, including recessive nonsyndromic deafness DFNB86, dominant nonsyndromic deafness DFNA65, seizure accompanied by deafness, a variety of isolated seizure phenotypes and DOORS syndrome, characterized by deafness, onychodystrophy, osteodystrophy, intellectual ...
Huang, Miaolin; van der Borght, Carolien; Leithaus, Merel; 127690; Flamaing, Johan; 35377; Goderis, Geert; 47213;
BACKGROUND: Although 'frequent flyer' hospital admissions represent barely 3 to 8% of the total patient population in a hospital, they are responsible for a disproportionately high percentage (12 to 28%) of all admissions. Moreover, hospital admissions are an important contributor to health care costs and overpopulation in various hospitals. The ai...