Argañaraz, Gustavo A. Palmeira, Julys da Fonseca Argañaraz, Enrique R.
Published in
Cell Communication and Signaling
The rapid ability of SARS-CoV-2 to spread among humans, along with the clinical complications of coronavirus disease 2019—COVID-19, have represented a significant challenge to the health management systems worldwide. The acute inflammation and coagulation abnormalities appear as the main causes for thousands of deaths worldwide. The intense inflamm...
Zheng, Yuanpeng Verhoeff, Tessa A Perez Pardo, Paula Garssen, Johan Kraneveld, Aletta D
Published in
International journal of molecular sciences
Autism Spectrum Disorder (ASD) is a spectrum of disorders that are characterized by problems in social interaction and repetitive behavior. The disease is thought to develop from changes in brain development at an early age, although the exact mechanisms are not known yet. In addition, a significant number of people with ASD develop problems in the...
Fang, Renpeng Haxaire, Coline Otero, Miguel Lessard, Samantha Weskamp, Gisela McIlwain, David R Mak, Tak W Lichtenthaler, Stefan F Blobel, Carl P
Published in
International journal of molecular sciences
Growth of the axial and appendicular skeleton depends on endochondral ossification, which is controlled by tightly regulated cell-cell interactions in the developing growth plates. Previous studies have uncovered an important role of a disintegrin and metalloprotease 17 (ADAM17) in the normal development of the mineralized zone of hypertrophic chon...
Lorenzen, Inken Eble, Johannes A Hanschmann, Eva-Maria
Published in
Biological chemistry
Redox-mediated signal transduction depends on the enzymatic production of second messengers such as hydrogen peroxide, nitric oxide and hydrogen sulfite, as well as specific, reversible redox modifications of cysteine-residues in proteins. So-called thiol switches induce for instance conformational changes in specific proteins that regulate cellula...
Xiang, Yuqi Liu, Liyu Wang, Ying Li, Bo Peng, Jinwu Feng, Deyun
Published in
Cancer Cell International
BackgroundThe upregulation of ADAM17 has been reported to be associated with invasion and metastasis in various tumors, however the molecular mechanism of ADAM17 in the progression of hepatocellular carcinoma (HCC) remain to be clarified. Human matrix metalloproteinase 21 (MMP21), the newest member of the MMP gene family, has been suggested to play...
Zipeto, Donato Palmeira, Julys da Fonseca Argañaraz, Gustavo Adolfo Argañaraz, Enrique Roberto
The Coronavirus Disease 2019 (COVID-19) has already caused hundreds of thousands of deaths worldwide in a few months. Cardiovascular disease, hypertension, diabetes and chronic lung disease have been identified as the main COVID-19 comorbidities. Moreover, despite similar infection rates between men and women, the most severe course of the disease ...
Zipeto, Donato Palmeira, Julys da Fonseca Argañaraz, Gustavo A Argañaraz, Enrique R
Published in
Frontiers in immunology
The Coronavirus Disease 2019 (COVID-19) has already caused hundreds of thousands of deaths worldwide in a few months. Cardiovascular disease, hypertension, diabetes and chronic lung disease have been identified as the main COVID-19 comorbidities. Moreover, despite similar infection rates between men and women, the most severe course of the disease ...
Fan, Changru Yuan, Qiulan Liu, Guifeng Zhang, Yuliang Yan, Maojun Sun, Qingxu Zhu, Chaoyu
Published in
Cancer Cell International
BackgroundColorectal cancer (CRC) is one of the most general malignant tumors. Accumulating evidence implied that long non-coding RNA Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1) participated in the tumorigenesis of CRC. However, the effect of MALAT1 in drug-resistance needed to be further illustrated.MethodsLevels of MALAT1, mic...
Chen, Qi Guo, Sheng Min Huang, Hou Qiang Huang, Guo Ping Li, Yi Li, Zi Hui Huang, Run Xiao, Lu Fan, Chun Rong Yuan, Qing
...
Published in
Aging (Albany NY)
Non-small cell lung cancer (NSCLC) is a type of refractory malignant lung cancer with a high rate of metastasis and mortality. Currently, long non-coding RNA (lncRNA) SBF2 Antisense RNA 1 (SBF2-AS1) is considered as a biomarker for a variety of tumors. However, the function of SBF2-AS1 in the growth and metastasis of NSCLC needs to be further studi...
e Costa, Rute A.P. Granato, Daniela C. Trino, Luciana D. Yokoo, Sami Carnielli, Carolina M. Kawahara, Rebeca Domingues, Romênia R. Pauletti, Bianca Alves Neves, Leandro Xavier Santana, Aline G.
...
Published in
Redox Biology
The activity of Thioredoxin-1 (Trx-1) is adjusted by the balance of its monomeric, active and its dimeric, inactive state. The regulation of this balance is not completely understood. We have previously shown that the cytoplasmic domain of the transmembrane protein A D isintegrin A nd M etalloprotease 17 (ADAM17cyto) binds to Thioredoxin-1 (Trx-1) ...
