Van Liefferinge, Elout Van Noten, Noémie Degroote, Jeroen Vrolix, Gunther Van Poucke, Mario Peelman, Luc Van Ginneken, Chris Roura, Eugeni Michiels, Joris
Published in
Animals : an open access journal from MDPI
Transient receptor potential (TRP) channels contribute to sensory transduction in the body, agonized by a variety of stimuli, such as phytochemicals, and they are predominantly distributed in afferent neurons. Evidence indicates their expression in non-neuronal cells, demonstrating their ability to modulate gastrointestinal function. Targeting TRP ...
Giotis, E Laidlaw, S Bidgood, S Albrecht, D Burden, J Robey, R Mercer, J Skinner, M
The avian pathogen fowlpox virus (FWPV) has been successfully used as a vaccine vector in poultry and humans, but relatively little is known about its ability to modulate host antiviral immune responses in these hosts, which are replication-permissive and nonpermissive, respectively. FWPV is highly resistant to avian type I interferon (IFN) and abl...
Buratin, Alessia Paganin, Maddalena Gaffo, Enrico Dal Molin, Anna Roels, Juliette Germano, Giuseppe Siddi, Maria Teresa Serafin, Valentina De Decker, Matthias Gachet, Stéphanie
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Published in
Blood advances
Circular RNAs (circRNAs) are stable RNA molecules that can drive cancer through interactions with microRNAs and proteins and by the expression of circRNA encoded peptides. The aim of the study was to define the circRNA landscape and potential impact in T-cell acute lymphoblastic leukemia (T-ALL). Analysis by CirComPara of RNA-sequencing data from 2...
Schreglmann, S Wang, D Peach, R Li, J Zhang, X Latorre, A Rhodes, E Panella, E Cassara, A Boyden, E
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Aberrant neural oscillations hallmark numerous brain disorders. Here, we first report a method to track the phase of neural oscillations in real-time via endpoint-corrected Hilbert transform (ecHT) that mitigates the characteristic Gibbs distortion. We then used ecHT to show that the aberrant neural oscillation that hallmarks essential tremor (ET) ...
Li, Wenjin Guillaume, Joren Baqi, Younis Wachsmann, Isabell Gieselmann, Volkmar Van Calenbergh, Serge Müller, Christa E
Published in
Journal of enzyme inhibition and medicinal chemistry
Metachromatic leukodystrophy (MLD) is a rare genetic disease characterised by a dysfunction of the enzyme arylsulphatase A leading to the lysosomal accumulation of cerebroside sulphate (sulphatide) causing subsequent demyelination in patients. The enzyme galactosylceramide (cerebroside) sulphotransferase (CST) catalyses the transfer of a sulphate g...
Ranjan, Prabhat; 114162; Pillitteri, Serena; 136545; van der Eycken, Erik; 7655; Sharma, Upendra K; 89708;
status: published
Azari, Bahar; Westlin, Christiana; Satpute, Ajay B; Hutchinson, J Benjamin; Kragel, Philip A; Hoemann, Katie; 140689; Khan, Zulqarnain; Wormwood, Jolie B; Quigley, Karen S; Erdogmus, Deniz;
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Machine learning methods provide powerful tools to map physical measurements to scientific categories. But are such methods suitable for discovering the ground truth about psychological categories? We use the science of emotion as a test case to explore this question. In studies of emotion, researchers use supervised classifiers, guided by emotion ...
Maynard, S Gelmi, A Skaalure, S Pence, I Lee-Reeves, C Sero, J Whittaker, T Stevens, M
A common approach to tailoring synthetic hydrogels for regenerative medicine applications involves incorporating RGD cell adhesion peptides, yet assessing the cellular response to engineered microenvironments at the nanoscale remains challenging. To date, no study has demonstrated how RGD concentration in hydrogels affects the presentation of indiv...
van Cann, Marianne; Kuzmenkov, Alexey; Isensee, Jorg; Andreev-Andrievskiy, Alexander; Peigneur, Steve; 56122; Khusainov, Georgii; Berkut, Antonina; Tytgat, Jan; 18354; Vassilevski, Alexander; Hucho, Tim;
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Venoms are a rich source of highly specific toxins, which allow the identification of novel therapeutic targets. We have now applied high content screening (HCS) microscopy to identify toxins that modulate pain sensitization signaling in primary sensory neurons of rat and elucidated the underlying mechanism. A set of venoms and fractions thereof we...
Iannotta, Lucia; Biosa, Alice; Kluss, Jillian H; Tombesi, Giulia; Kaganovich, Alice; Cogo, Susanna; Plotegher, Nicoletta; Civiero, Laura; Lobbestael, Evy; 56414; Baekelandt, Veerle; 4499;
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Mutations in LRRK2 cause familial Parkinson's disease and common variants increase disease risk. LRRK2 kinase activity and cellular localization are tightly regulated by phosphorylation of key residues, primarily Ser1292 and Ser935, which impacts downstream phosphorylation of its substrates, among which Rab10. A comprehensive characterization of LR...
