Mangrove sediment organic carbon storage and sources in relation to forest age and position along a deltaic salinity gra...
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status: published
The Role of Taurine in Skeletal Muscle Functioning and Its Potential as a Supportive Treatment for Duchenne Muscular Dys...
Taurine (2-aminoethanesulfonic acid) is required for ensuring proper muscle functioning. Knockout of the taurine transporter in mice results in low taurine concentrations in the muscle and associates with myofiber necrosis and diminished exercise capacity. Interestingly, regulation of taurine and its transporter is altered in the mdx mouse, a model...
Osmotic Adjustment in Wheat (Triticum aestivum L.) During Pre- and Post-anthesis Drought
Published in Frontiers in Plant Science
Pre-anthesis drought is expected to greatly increase yield losses in wheat (Triticum aestivum L.), one of the most important crops worldwide. Most studies investigate the effects of pre-anthesis drought only at maturity. The physiology of the plant before anthesis and how it is affected during drought is less studied. Our study focused on physiolog...
Characterization of carotenoid biosynthetic pathway genes in the pea aphid (Acyrthosiphon pisum) revealed by heterologou...
Carotenoids are involved in many essential physiological functions and are produced from geranylgeranyl pyrophosphate through synthase, desaturase, and cyclase activities. In the pea aphid (Acyrthosiphon pisum), the duplication of carotenoid biosynthetic genes, including carotenoid synthases/cyclases (ApCscA-C) and desaturases (ApCdeA-D), through h...
Cupriavidus metallidurans NA4 actively forms polyhydroxybutyrate-associated uranium-phosphate precipitates
Cupriavidus metallidurans is a model bacterium to study molecular metal resistance mechanisms and its use for the bioremediation of several metals has been shown. However, its mechanisms for radionuclide resistance are unexplored. We investigated the interaction with uranium and associated cellular response to uranium for Cupriavidus metallidurans ...
Towards Multimodal Machine Learning Prediction of Individual Cognitive Evolution in Multiple Sclerosis
Multiple sclerosis (MS) manifests heterogeneously among persons suffering from it, making its disease course highly challenging to predict. At present, prognosis mostly relies on biomarkers that are unable to predict disease course on an individual level. Machine learning is a promising technique, both in terms of its ability to combine multimodal ...
Ferroptosis induction in multiple myeloma cells triggers DNA methylation and histone modification changes associated wit...
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Disease relapse and therapy resistance remain key challenges in treating multiple myeloma. Underlying (epi-)mutational events can promote myelomagenesis and contribute to multi-drug and apoptosis resistance. Therefore, compounds inducing ferroptosis, a form of iron and lipid peroxidation-regulated cell death, are appealing alternative treatment str...
Numerical study of gas production from fine-grained hydrate reservoirs using a multilateral horizontal well system
Natural gas hydrate is prevalent in ultralow-permeability fine-grained sediments with substantial reserves. However, effective and safe gas production from fine-grained hydrate reservoirs remains a global challenge. Here, a multilateral horizontal well system is innovatively employed to improve production efficiency in finegrained hydrate reservoir...
Numerical study of gas production from fine-grained hydrate reservoirs using a multilateral horizontal well system
Natural gas hydrate is prevalent in ultralow-permeability fine-grained sediments with substantial reserves. However, effective and safe gas production from fine-grained hydrate reservoirs remains a global challenge. Here, a multilateral horizontal well system is innovatively employed to improve production efficiency in finegrained hydrate reservoir...
Gut microbiome profiling uncovers a lower abundance of Butyricicoccus in advanced stages of chronic kidney disease
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Chronic kidney disease (CKD) is characterized by the accumulation of uremic toxins which exert deleterious effects on various organ systems. Several of these uremic toxins originate from the bacterial metabolization of aromatic amino acids in the colon. This study assessed whether the gut microbial composition varies among patients in different sta...
