Kannan, Pavitra Füredi, András Dizdarevic, Sabina Wanek, Thomas Mairinger, Severin Collins, Jeffrey Falls, Theresa van Dam, R Michael Maheshwari, Divya Lee, Jason T
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Published in
European journal of nuclear medicine and molecular imaging
Multidrug resistance (MDR) impedes cancer treatment. Two efflux transporters from the ATP-binding cassette (ABC) family, ABCB1 and ABCG2, may contribute to MDR by restricting the entry of therapeutic drugs into tumor cells. Although a higher expression of these transporters has been correlated with an unfavorable response to chemotherapy, transport...
Sivapackiam, Jothilingam Sharma, Monica Schindler, Thomas H. Sharma, Vijay
Published in
Current Cardiology Reports
Purpose of ReviewCurrently, cardiotoxicity is monitored through echocardiography or multigated acquisition scanning and is defined as 10% or higher LVEF reduction. The latter stage may represent irreversible myocardium injury and limits modification of therapeutic paradigms at earliest stages. To stratify patients for anthracycline-related heart fa...
Sekiya, Motohiro Matsuda, Takaaki Yamamoto, Yuki Furuta, Yasuhisa Ohyama, Mariko Murayama, Yuki Sugano, Yoko Ohsaki, Yoshinori Iwasaki, Hitoshi Yahagi, Naoya
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Published in
BMC Medical Genetics
BackgroundRenal hypouricemia (RHUC) is a hereditary disorder where mutations in SLC22A12 gene and SLC2A9 gene cause RHUC type 1 (RHUC1) and RHUC type 2 (RHUC2), respectively. These genes regulate renal tubular reabsorption of urates while there exist other genes counterbalancing the net excretion of urates including ABCG2 and SLC17A1. Urate metabol...
Ristic, Bojana Sivaprakasam, Sathish Narayanan, Monisha Ganapathy, Vadivel
Published in
Biochemical Journal
Hereditary hemochromatosis (HH) is mostly caused by mutations in the iron-regulatory gene HFE . The disease is associated with iron overload, resulting in liver cirrhosis/cancer, cardiomegaly, kidney dysfunction, diabetes, and arthritis. Fe2+-induced oxidative damage is suspected in the etiology of these symptoms. Here we examined, using Hfe −/− mi...
stenvang, jan budinská, eva van van cutsem, eric bosman, fred popovici, vlad brünner, nils
Biomarker-guided treatment for patients with colon cancer is needed. We tested ABCG2 and topoisomerase 1 (TOP1) mRNA expression as predictive biomarkers for irinotecan benefit in the PETACC-3 patient cohort. The present study included 580 patients with mRNA expression data from Stage III colon cancer samples from the PETACC-3 study, which randomize...
Stenvang, Jan; Budinska, Eva; van Cutsem, Eric; 3840; Bosman, Fred; Popovici, Vlad; Brunner, Nils;
Biomarker-guided treatment for patients with colon cancer is needed. We tested ABCG2 and topoisomerase 1 (TOP1) mRNA expression as predictive biomarkers for irinotecan benefit in the PETACC-3 patient cohort. The present study included 580 patients with mRNA expression data from Stage III colon cancer samples from the PETACC-3 study, which randomize...
Zhao, Can Hao, Huifeng Zhao, Haiyu Ren, Wei Jiao, Yanna An, Guo Sun, Hong Han, Shuyan Li, Pingping
Published in
Journal of ethnopharmacology
Marsdenia tenacissima extract (MTE) is the water-soluble part of a traditional Chinese medicine Marsdenia tenacissima (Roxb.) Wight & Arn, and is commercially available in China for treating cancers. MTE has been revealed to be effective in improving gefitinib efficacy in treating non-small cell lung cancer (NSCLC). However, the mechanisms remain t...
Liu, Jia Yang, Wei Li, Yun Wei, Zhanyun Dan, Xiaojuan
Published in
BMC Medical Genetics
BackgroundThe ABCG2 rs2231142 single nucleotide polymorphism (SNP) is one of the most significant genetic variants associated with hyperuricemia (HUA) in Asian populations. However, the risk of ABCG2 rs2231142 variants for HUA could interact with other important HUA risk variants and cardiovascular factors. This study investigated the effects of th...
Wrigley, Rebekah Phipps-Green, Amanda J. Topless, Ruth K. Major, Tanya J. Cadzow, Murray Riches, Philip Tausche, Anne-Kathrin Janssen, Matthijs Joosten, Leo A. B. Jansen, Tim L.
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Published in
Arthritis Research & Therapy
BackgroundThe ABCG2 Q141K (rs2231142) and rs10011796 variants associate with hyperuricaemia (HU). The effect size of ABCG2 rs2231142 on urate is ~ 60% that of SLC2A9, yet the effect size on gout is greater. We tested the hypothesis that ABCG2 plays a role in the progression from HU to gout by testing for association of ABCG2 rs2231142 and rs1001179...
Ambjørner, Sophie E. B. Wiese, Michael Köhler, Sebastian Christoph Svindt, Joen Lund, Xamuel Loft Gajhede, Michael Saaby, Lasse Brodin, Birger Rump, Steffen Weigt, Henning
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Published in
Cells
ATP-binding cassette (ABC) transporters, such as breast cancer resistance protein (BCRP), are key players in resistance to multiple anti-cancer drugs, leading to cancer treatment failure and cancer-related death. Currently, there are no clinically approved drugs for reversal of cancer drug resistance caused by ABC transporters. This study investiga...
