Ganoci, Lana Trkulja, Vladimir Živković, Maja Božina, Tamara Šagud, Marina Lovrić, Mila Božina, Nada
Published in
Progress in neuro-psychopharmacology & biological psychiatry
The relevance of the multidrug resistance (ABCB1) and breast cancer resistance (ABCG2) protein transporter polymorphisms for treatment with long-acting intramuscular (LAI) risperidone is largely unknown. We explored the relationship between these polymorphisms and cytochrome P450 (CYP) 2D6 genotype-predicted phenotype in their effects on drug dispo...
Köttgen, Anna Köttgen, Michael
Published in
Kidney international
Kim, Chae Eun Park, Ha Young Won, Hae Jeong Kim, Minyoung Kwon, Byungsuk Lee, Su-Jun Kim, Dong Hyun Shin, Jae-Gook Seo, Su-Kil
Published in
The international journal of biochemistry & cell biology
Even though subclasses of macrophage have distinct roles during progression of infectious diseases, it remains poorly understood whether there is a subset-specific difference in drug responses. Here, we report that ABCG2 was expressed specifically in M2-like macrophages and that it controlled their efflux activities. Abcg2 expression is markedly in...
Crowe, Andrew
Published in
SLAS discovery : advancing life sciences R & D
In drug discovery it is essential that one of the parameters tested for any new chemical entity is its affinity for human efflux systems, most notably P-glycoprotein (P-gp). These efflux systems affect not only rates of oral absorption but also rates of excretion through the liver, blood-brain barrier, and accumulation in potential target cells tha...
Sakamoto, Sho Sato, Kazuhiro Takita, Yuri Izumiya, Yuka Kumagai, Naho Sudo, Kazuhisa Hasegawa, Yukiyasu Yokota, Hayato Akamine, Yumiko Okuda, Yuji
...
Published in
Investigational new drugs
ATP-binding castle protein G2 (ABCG2) is thought to inhibit the activities of certain gefitinib transporters, thereby affecting drug pharmacokinetics. The C421A polymorphism affects the function and expression of ABCG2 on the cell membrane. Previous studies have shown that proton-pump inhibitors (PPIs) inhibit gefitinib absorption, as well as the f...
Wadhwa, Bhumika Paddar, Masroor Khan, Sameer Mir, Sameer A Clarke, Philip Grabowska, Anna M Vijay, Devanahalli G Malik, Fayaz
Published in
Oncotarget
AKT, a serine threonine kinase, exists in three different isoforms and is known for regulating several biological processes including tumorigenesis. In this study, we investigated the expression and net effect of the individual isoforms in triple negative breast cancers and response to cisplatin treatment using cellular, mice models and clinical sa...
Khunweeraphong, Narakorn Kuchler, Karl
Published in
FEBS letters
The human multidrug transporter ABCG2 is required for physiological detoxification and mediates anticancer drug resistance. Here, we identify pivotal residues in the first intracellular loop (ICL1), constituting an intrinsic part of the transmission interface. The architecture includes a triple helical bundle formed by the hot spot helix of the nuc...
Rattanacheeworn, Punyabhorn Chamnanphon, Monpat Thongthip, Siriwan Kittanamongkolchai, Wonngarm Townamchai, Natavudh Avihingsanon, Yingyos Udomnilobol, Udomsak Prueksaritanont, Thomayant Jianmongkol, Suree Chariyavilaskul, Pajaree
...
Published in
Pharmacogenomics and Personalized Medicine
Introduction Genetic polymorphisms of drug transporters influence drug transporter activity and alter pharmacokinetic profiles of the drugs. Organic anion transporting polypeptide 1B1 (OATP1B1) and breast cancer resistance protein (BCRP) are important transporters encoded by solute carrier organic anion transporter family member 1B1 ( SLCO1B1 ) gen...
Lukkunaprasit, Thitiya Rattanasiri, Sasivimol Turongkaravee, Saowalak Suvannang, Naravut Ingsathit, Atiporn Attia, John Thakkinstian, Ammarin
Published in
BMC Medical Genetics
BackgroundReplication studies showed conflicting effects of ABCG2 and SLC2A9 polymorphisms on gout and serum urate. This meta-analysis therefore aimed to pool their effects across studies.MethodsStudies were located from MEDLINE and Scopus from inception to 17th June 2018. Observational studies in adults with any polymorphism in ABCG2 or SLC2A9, an...
Sarkadi, Balázs Homolya, László Hegedűs, Tamás
Published in
FEBS letters
The ABCG2 protein has a key role in the transport of a wide range of structurally dissimilar endo- and xenobiotics in the human body, especially in the tissue barriers and the metabolizing or secreting organs. The human ABCG2 gene harbors a high number of polymorphisms and mutations, which may significantly modulate its expression and function. Rec...
