Guidony, Nicole Soares Scaini, João Luís Rheingantz Oliveira, Matheus William Bandeira Machado, Karina Santos Bastos, Cláudio Escarrone, Ana Laura Souza, Marta Marques
Published in
Environmental pollution (Barking, Essex : 1987)
Chemicals such as triclosan are a concern because of their presence on daily products (soap, deodorant, hand sanitizers …), consequently this compound has an ubiquitous presence in the environment. Little is known about the effect of this bactericide on aquatic life. The aim of this study is to analyze triclosan exposure (24 h) to an in vitro model...
Kim, Kwang Yeon Kim, Tae Hyeong Seong, Moon-Woo Park, Sung Sup Moon, Jin Soo Ko, Jae Sung
Published in
BMC Pediatrics
BackgroundDubin-Johnson syndrome (DJS) is an autosomal recessive disorder presenting as isolated direct hyperbilirubinemia.DJS is rarely diagnosed in the neonatal period. The purpose of this study was to clarify the clinical features of neonatal DJS and to analyze the genetic mutation of adenosine triphosphate-binding cassette subfamily C member 2 ...
Huang, Jianlei Xu, Yanjun Zuo, Yayun Yang, Yihua Tabashnik, Bruce E Wu, Yidong
Published in
Insect biochemistry and molecular biology
Insecticidal proteins from the bacterium Bacillus thuringiensis (Bt) can provide safe and effective control of some major pests, but evolution of resistance by pests diminishes these benefits. Better understanding of the genetics and mechanisms of resistance is urgently needed to improve methods for monitoring, managing, and countering pest resista...
Zeng, Guangting Shi, Lihong Li, Huilan Wang, Linlin Zhu, Miaomiao Luo, Jia Zhang, Zanling
Published in
Xenobiotica; the fate of foreign compounds in biological systems
1. Voriconazole is known to display highly variable pharmacokinetics affecting treatment efficacy and safety. This study aimed to identify the factors causing the variation of voriconazole concentration in patients with allogeneic hematopoietic stem cell transplantation.2. The data of patients was collected, including clinical characteristics and v...
Xun, Tianrong Lin, Zhufen Zhan, Xia Song, Shaolian Mo, Liqian Feng, Haixing Yang, Qin Guo, Dan Yang, Xixiao
Published in
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Clinical and benchtop studies suggest that chronic kidney disease (CKD) alters both renal and nonrenal clearance of drugs. Although studies have documented that the accumulating uremic toxins in the body under CKD conditions are humoral factors that alter the expression and/or activity of drug transporters, the specific process is poorly understood...
Wang, Xingliang Xu, Yanjun Huang, Jianlei Jin, Wenzhong Yang, Yihua Wu, Yidong
Published in
Toxins
The adoption of transgenic crops expressing Bacillus thuringiensis (Bt) insecticidal crystalline (Cry) proteins has reduced insecticide application, increased yields, and contributed to food safety worldwide. However, the efficacy of transgenic Bt crops is put at risk by the adaptive resistance evolution of target pests. Previous studies indicate t...
Lian, Guo Yuan, Jia Gao, Yuan
Published in
OncoTargets and therapy
Objective Multidrug resistance-associated protein 2 (MRP2), encoded by ABCC2 gene, is involved in the efflux of certain anticancer drugs. Here we observed whether the ABCC2 (G1249A) polymorphism impacts the transport abilities of MRP2-dependent paclitaxel, docetaxel, and doxorubicin in recombinant LLC-PK1 cell lines. Methods LLC-PK1 cell lines tran...
Zhu, Bin Sun, Xi Nie, Ximan Liang, Pei Gao, Xiwu
Published in
Insect biochemistry and molecular biology
Cry protein toxins produced by Bacillus thuringiensis (Bt) are now widely used in sprays and transgenic crops to control insect pests. Most recently, ATP-binding cassette transporter proteins (ABC transporter), including ABCC2, ABCC3, ABCG1, ABCA2 and ABCB1, were reported as putative receptors for different Cry toxins. However, little is known abou...
Corpechot, Christophe Barbu, Véronique Chazouillères, Olivier Broué, Pierre Girard, Muriel Roquelaure, Bertrand Chrétien, Yves Dong, Catherine Lascols, Olivier Housset, Chantal
...
Published in
Liver international : official journal of the International Association for the Study of the Liver
The ABCC2 gene is implicated in Dubin-Johnson syndrome (DJS), a rare autosomal recessive liver disorder. The primary aim of this study was to determine the diagnostic value of ABCC2 genetic testing in the largest cohort of DJS reported to date. The high number of patients with cholestatic manifestations in this series prompted us to evaluate the ge...
Li, Yuan Li, Yang Yang, Yang Yang, Wen-Rui Li, Jian-Ping Peng, Guang-Xin Song, Lin Fan, Hui-Hui Ye, Lei Xiong, You-Zhen
...
Published in
World journal of clinical cases
Hereditary spherocytosis (HS) is a hereditary disease of hemolytic anemia that occurs due to the erythrocyte membrane defects. Dubin-Johnson syndrome (DJS), which commonly results in jaundice, is a benign hereditary disorder of bilirubin clearance that occurs only rarely. The co-occurrence of HS and DJS is extremely rare. We recently diagnosed and ...
