Published in Redox Biology
CYP27A1: cholesterol 27-hydroxylase; CYP7A1: cholesterol 7-alpha-hydroxylase; CYP7B1: noxysterol 7-alpha-hydroxylase; CYP11A1: cholesterol side-chain cleavage enzyme; 25OHC: 25-hydroxycholesterol; 27OHC:27-hydroxycholesterol; 20SOHC: 20 (S)-hydroxycholesterol; 22ROHC:22(R)-hydroxycholesterol; 22SOHC:22(S)-hydroxycholesterol; 7 KC:7-ketocholesterol;...
Aging is characterized by a progressive increase in oxidative stress, which favors lipid peroxidation and the formation of cholesterol oxide derivatives, including 7β-hydroxycholesterol (7β-OHC). This oxysterol, which is known to trigger oxidative stress, inflammation, and cell death, could contribute to the aging process and age-related diseases, ...
Published in Advances in experimental medicine and biology
Peroxisomopathies are qualitative or quantitative deficiencies in peroxisomes which lead to increases in the level of very-long-chain fatty acids (VLCFA) and can be associated with more or less pronounced dysfunction of central nervous system cells: glial and microglial cells. Currently, in frequent neurodegenerative diseases, Alzheimer's disease (...
International audience
Published in The Journal of steroid biochemistry and molecular biology
Oxidative stress and mitochondrial dysfunction contribute to the pathogenesis of neurodegenerative diseases and favor lipid peroxidation, leading to increased levels of 7β-hydroxycholesterol (7β-OHC) which induces oxiapoptophagy (OXIdative stress, APOPTOsis, autoPHAGY). The cytoprotective effects of dimethylfumarate (DMF), used in the treatment of ...
Steroidal maleic anhydrides were prepared in one step: lithocholic, chenodeoxicholic,deoxicholic, ursocholic, and hyodeoxicholic acid derivatives. Their capability to induce celldeath was studied on C6 rat glioma cells, and 7β-hydroxycholesterol was used as positivecytotoxic control. The highest cytotoxicity was observed with lithocholic andchenode...
Published in Biomedical and environmental sciences : BES
Age-related diseases, including neurodegenerative diseases, are associated with oxidative stress and lipid peroxidation, and increase the levels of cholesterol auto-oxidation products such as 7β-hydroxycholesterol (7β-OHC). Thus, it is imperative to identify agents that can prevent 7β-OHC-induced side-effects. We evaluated the potential protective ...
Published in Molecular nutrition & food research
α-Asarone blocked 7β-hydroxycholesterol-induced macrophage apoptosis through allaying ER stress-specific signaling involving caspase activation and CHOP induction. α-Asarone was an anti-atherosclerotic agent antagonizing ER stress-mediated macrophage apoptosis by 7β-hydroxycholesterol.
Published in The Journal of steroid biochemistry and molecular biology
Altered cholesterol metabolism could be associated with cognitive impairment. The quantitative profiling of 19 hair sterols was developed using gas chromatography-mass spectrometry coupled to multivariate data analysis. The limit of quantification of all sterols ranged from 5 to 20 ng/g, while the calibration linearity was higher than 0.98. The pre...
Published in Toxicology and Applied Pharmacology
•High-cholesterol diet induces CCR5L expression, like CCL3 and CCL4, in ApoE−/− mice.•27OHChol and 7αOHChol enhance secretion of CCL3 and CCL4 by monocytic cells.•The secreted CCR5 ligands promote migration of CCR5-expressing Th1 cells.•We report a mechanism underlying Th1 cell recruitment into atherosclerotic lesions.
