Published in Frontiers in Physiology
As a result of stress, injury, or aging, cardiac fibrosis is characterized by excessive deposition of extracellular matrix (ECM) components resulting in pathological remodeling, tissue stiffening, ventricular dilatation, and cardiac dysfunction that contribute to heart failure (HF) and eventually death. Currently, there are no effective therapies s...
Published in Frontiers in Bioengineering and Biotechnology
Endothelial cells (ECs) are an important component of the tumor microenvironment, playing key roles in tumor development and progression that span from angiogenesis to immune regulation and drug resistance. Heterotypic tumor spheroids are one of the most widely used in vitro tumor microenvironment models, presenting improved recapitulation of tumor...
Published in Open Archaeology
This paper presents a new rapid, low-cost method for the large-scale documentation of pottery sherds through simultaneous multiple 3D model capture using Structure from Motion (SfM). The method has great potential to enhance and replace time-consuming and expensive conventional approaches for pottery documentation, i.e., 2D photographs and drawing ...
Technical advances in 3D imaging have contributed to quantifying and understanding biological variability and complexity. However, small, dry‐sensitive objects are not easy to reconstruct using common and easily available techniques such as photogrammetry, surface scanning, or micro‐CT scanning. Here, we use cephalopod beaks as an example as their ...
Published in International journal of legal medicine
This paper introduces an automated method for estimating sex from the lower and upper limbs based on diaphyseal CSG properties. The proposed method was developed and evaluated using 389 femurs, 412 tibias, and 404 humeri of adult individuals from a modern Greek reference sample, the Athens Collection. The skeletal properties, which were extracted w...
Published in Russian Engineering Research
AbstractOntological aspects of subject fields in preproduction systems (CAM and CAPP systems) and shop-floor planning systems (MES systems) are outlined, with a view to subsequent integration of corporate applications at the semantic level. The subject area of CAM systems is found to be a component of the subject area of CAPP systems, while the ont...
Published in Frontiers in Bioengineering and Biotechnology
The use of tissue-engineered 3D models of cancer has grown in popularity with recent advances in the field of cancer research. 3D models are inherently more biomimetic compared to 2D cell monolayers cultured on tissue-culture plastic. Nevertheless 3D models still lack the cellular and matrix complexity of native tissues. This review explores differ...
Published in Advanced drug delivery reviews
The complexity and diversity of the biochemical processes that occur during tumorigenesis and metastasis are frequently over-simplified in the traditional in vitro cell cultures. Two-dimensional cultures limit researchers' experimental observations and frequently give rise to misleading and contradictory results. Therefore, in order to overcome the...
Published in Frontiers in Pharmacology
The substantial progress of the human induced pluripotent stem cell (hiPSC) technologies over the last decade has provided us with new opportunities for cardiovascular drug discovery, regenerative medicine, and disease modeling. The combination of hiPSC with 3D culture techniques offers numerous advantages for generating and studying physiological ...
Published in Medical Science Educator
In this paper, we describe a novel process for creating high-resolution, 3D PDF, 3D printed, and holographic anatomic and pathology models using inexpensive consumer grade electronics , which can be incorporated in any undergraduate or graduate medical school curriculum. Supplementary Information The online version contains supplementary material a...
