Risk evaluation is ubiquitous in decisions. Deep brain stimulation of the subthalamic nucleus is effective for Parkinson’s disease and obsessive–compulsive disorder, and can be associated with impulsivity and hypomania. Subthalamic stimulation has seemingly contrasting effects on impulsivity enhancing conflict-induced impulsivity but decrea...
Peer reviewed: True / Ovarian cancer is a highly aggressive malignancy with limited therapeutic options and a poor prognosis. Deubiquitinating enzymes (DUBs) have emerged as critical regulators of protein ubiquitination and proteasomal degradation, influencing various cellular processes relevant to cancer pathogenesis. In this study, the ...
This study employed the Delphi method to identify the ideal characteristics of a clozapine adverse drug reaction (ADR) scale, engaging 34 clozapine specialists at the 6th NEMEA meeting. Participants emphasized the integration of clinician-rated (CROM) and patient-rated (PROM) outcomes in the scale, aiming for a balance between comprehensiveness and...
Background Consumption of stimulant drugs, a heterogeneous group of addictive substances, has significantly increased in recent years with rising numbers of stimulant-associated intoxications and deaths. Objectives To provide an overview of recent scientific evidence of the diagnosis and treatment of stimulant use disorders. Material and methods A ...
Only some vulnerable individuals who recreationally drink alcohol eventually develop the compulsive drinking pattern that characterizes alcohol use disorder. A new frontier in biomedical research lies in understanding the neurobehavioral mechanisms of this individual vulnerability, a necessary step towards developing novel effective therape...
Cannabis use has been anecdotally linked with reduced motivation, sometimes referred to as the ‘amotivational syndrome’. In this review, we evaluate research on the association between acute and non-acute cannabis use and motivation assessed with questionnaire or behavioural task-based measures, focusing on studies publishe...
Cannabis use has been anecdotally linked with reduced motivation, sometimes referred to as the ‘amotivational syndrome’. In this review, we evaluate research on the association between acute and non-acute cannabis use and motivation assessed with questionnaire or behavioural task-based measures, focusing on studies publishe...
Psychedelic therapy is, arguably, the next frontier in psychiatry. It offers a radical alternative to longstanding, mainstays of treatment, while exciting a paradigm shift in translational science and drug discovery. There is particular interest in 5-methoxy-
Acknowledgements: The authors have declared that there are no conflicts of interest in relation to the subject of this study. / Funder: Economic and Social Research Council; DOI: https://doi.org/10.13039/501100000269 / Funder: University of Cambridge; DOI: https://doi.org/10.13039/501100000735 / The Salience Hypothesis posits that...
The first endothelin (ET)-1 receptor antagonist was approved for clinical use over 20 years ago but to date, this class of compounds has been limited to treating pulmonary arterial hypertension, a rare disease. Translational research over the last 5 years has re-ignited interest in the endothelin system as a therapeutic target across the spectrum o...
