The COvid-19 vascular sERvice (COVER) study: an international vascular and endovascular research network (VERN) collabor...
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CNS penetration of potential anti-COVID-19 drugs.
Implications for COVID-19 triage from the ICNARC report of 2204 COVID-19 cases managed in UK adult intensive care units
What is the best drug to treat COVID-19? The need for randomized controlled trials
Temporal trends in the incidence of heart failure among patients with COPD and its association with mortality
Rationale: Heart failure (HF) is a common comorbidity in the chronic obstructive pulmonary disease (COPD) population, but previous research has shown under recognition. Objectives: To determine the incidence of HF in a prevalent COPD cohort. To determine the association of incident HF with short- and long-term mortality of patients with COPD. Metho...
The randomized embedded multifactorial adaptive platform for community-acquired pneumonia (REMAP-CAP) study: rationale a...
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There is broad interest in improved methods to generate robust evidence regarding best practice, especially in settings where patient conditions are heterogenous and require multiple concomitant therapies. Here, we present the rationale and design of a large, international trial that combines features of adaptive platform trials with pragmatic poin...
British Society of Gastroenterology guidance for management of inflammatory bowel disease during the COVID-19 pandemic
Health surveillance during covid-19 pandemic
B cell rich meningeal inflammation associates with increased spinal cord pathology in multiple sclerosis
Increased inflammation in the cerebral meninges is associated with extensive subpial cortical grey matter pathology in the forebrain and a more severe disease course in a substantial proportion of secondary progressive multiple sclerosis (SPMS) cases. It is not known whether this relationship extends to spinal cord pathology. We assessed the contri...
Presence of pleomorphic features but not growth patterns improves prognostic stratification of epithelioid malignant ple...
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AIMS: Nuclear grade has been recently validated as a powerful prognostic tool in epithelioid malignant pleural mesothelioma (E-MPM). In other studies histological parameters including pleomorphic features and growth patterns were also shown to exert prognostic impact. The primary aims of our study are (1) externally validate the prognostic role of ...
