The indirect effects of the COVID-19 pandemic on people with type 2 diabetes - time to urgently move into a recovery pha...
Prioritisation of candidate genes underpinning COVID-19 host genetic traits based on high-resolution 3D chromosomal topo...
Genetic variants showing associations with specific biological traits and diseases detected by genome-wide association studies (GWAS) commonly map to non-coding DNA regulatory regions. Many of these regions are located considerable distances away from the genes they regulate and come into their proximity through 3D chromosomal interactions. We prev...
Passive Monitoring at Home: A Pilot Study in Parkinson Disease
Published in Digital Biomarkers
We conducted a pilot study using a passive radio-wave-based home monitor in individuals with Parkinson disease (PD) with a focus on gait, home activity, and time in bed. We enrolled 7 ambulatory individuals to have the device installed in the bedroom of their homes over 8 weeks and performed standard PD assessments at baseline. We evaluated the abi...
Modelling trajectories of parentally reported and physician-confirmed atopic dermatitis in a birth cohort study.
BACKGROUND: In a population-based birth cohort, we aimed to identify longitudinal trajectories of atopic dermatitis (AD) during childhood using data from different sources (validated questionnaires and healthcare records), investigate impact of different AD definitions on such trajectories and their relationships with various risk factors. METHODS:...
Effect of visual input on syllable parsing in a computational model of a neural microcircuit for speech processing.
Seeing a person talking can help to understand them, in particular in a noisy environment. However, how the brain integrates the visual information with the auditory signal to enhance speech comprehension remains poorly understood. Here we address this question in a computational model of a cortical microcircuit for speech processing. The model con...
A whole population cohort study of changes in neonatal admissions, care processes and outcomes in England and Wales duri...
Objectives: The COVID-19 pandemic instigated multiple societal and healthcare interventions with potential to affect perinatal practice. We evaluated population-level changes in preterm and full-term admissions to neonatal units, care processes, and outcomes. Design: Observational cohort study utilising the UK National Neonatal Research Database Se...
Clinical utility of home versus hospital spirometry in fibrotic ILD: evaluation following INJUSTIS interim analysis.
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Study protocol for “Psilocybin as a Treatment for Anorexia Nervosa: A Pilot Study"
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Background: Anorexia nervosa (AN) is a serious and life-threatening psychiatric condition. With a paucity of approved treatments, there is a desperate need for novel treatment avenues to be explored. Here, we present 1) an overview of the ways through which Public Patient Involvement (PPI) has informed a trial of psilocybin-assisted therapy for AN ...
Bi-unicondylar arthroplasty: a biomechanics and clinical outcomes study
Aims Bi-Unicondylar Arthroplasty (Bi-UKA) is a bone and anterior cruciate ligament (ACL) preserving alternative to Total Knee Arthroplasty (TKA) when the patellofemoral joint is preserved. The aim of this study is to investigate the clinical outcomes and biomechanics of Bi-UKA. Methods Bi-UKA subjects (N = 22) were measured on an instrumented tread...
The current and possible future role of 3D modelling within oesophagogastric surgery: a scoping review protocol
Introduction Three-dimensional (3D) reconstruction describes the generation of either virtual or physically printed anatomically accurate 3D models from two-dimensional (2D) medical images. Their implementation has revolutionised medical practice. Within surgery, key applications include growing roles in operative planning and procedures, surgical ...
