The burden of diabetes in the Americas
Blood pressure-lowering treatment for prevention of major cardiovascular diseases in people with and without type 2 diab...
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BACKGROUND: Controversy exists as to whether the threshold for blood pressure-lowering treatment should differ between people with and without type 2 diabetes. We aimed to investigate the effects of blood pressure-lowering treatment on the risk of major cardiovascular events by type 2 diabetes status, as well as by baseline levels of systolic blood...
Measurement of postmortem outflow facility using iPerfusion.
The key risk factor for glaucoma is elevation of intraocular pressure (IOP) and alleviating it is the only effective therapeutic approach to inhibit further vision loss. IOP is regulated by the flow of aqueous humour across resistive tissues, and a reduction in outflow facility, is responsible for the IOP elevation in glaucoma. Measurement of outfl...
Genetic analyses of circulating PUFA-derived mediators identifies heritable dihydroxyeicosatrienoic acid species
Estimates of heritability are the first step in identifying a trait with substantial variation due to genetic factors. Large-scale genetic analyses can identify the DNA variants that influence the levels of circulating lipid species and the statistical technique Mendelian randomisation can use these DNA variants to address potential causality of th...
Diabetes mortality and trends before 25 years of age: an analysis of the Global Burden of Disease Study 2019
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Background Diabetes, particularly type 1 diabetes, at younger ages can be a largely preventable cause of death with the correct health care and services. We aimed to evaluate diabetes mortality and trends at ages younger than 25 years globally using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. Methods We use...
Secondary amplification of sperm DNA fragmentation for male infertility: hope for improved and affordable fertility test...
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Therapeutic opportunities for senolysis in cardiovascular disease
Cellular senescence within the cardiovascular system has, until recently, been understudied and unappreciated as a factor in the development of age-related cardiovascular diseases such as heart failure, myocardial infarction and atherosclerosis. This is in part due to challenges with defining senescence within post-mitotic cells such as cardiomyocy...
Defend or reproduce? Muscle-derived glutamate determines an immune/reproductive energetic tradeoff
There are dramatic disparities in infection susceptibility within populations. In this issue of Cell Metabolism, Zhao and Karpac uncover a muscle-adipose-gut axis in Drosophila that explains variability in pathogen susceptibility. The degree of intramuscular NF-kB activation accounts for differences in circulating glutamate, which enhances resistan...
Trends in leading causes of hospitalisation among adults with diabetes in England from 2003 to 2018: an epidemiological ...
Background Diabetes mellitus (DM) leads to a wide range of established vascular and metabolic complications which has resulted in specific prevention programmes being implemented across high-income countries. DM has been associated with increased risk of a broader set of conditions including cancers, liver disease and common infections. We aimed to...
