Brogaard, Louise Schou, Kirstine Klitgaard Heegaard, Peter M. H. Hansen, Mette Sif Jensen, Tim Kåre Skovgaard, Kerstin
Background: Actinobacillus pleuropneumoniae causes pleuropneumonia in pigs, a disease which is associated with high morbidity and mortality, as well as impaired animal welfare. To obtain in-depth understanding of this infection, the interplay between virulence factors of the pathogen and defense mechanisms of the porcine host needs to be elucidated...
Kepp, Kasper Planeta
Late-onset neurodegenerative diseases remain poorly understood as search continues for the perceived pathogenic protein species. Previously, variants in Superoxide Dismutase 1 (SOD1) causing Amyotrophic Lateral Sclerosis (ALS) were found to destabilize and reduce net charge, suggesting a pathogenic aggregation mechanism. This paper reports analysis...
Kepp, Kasper Planeta
Late-onset neurodegenerative diseases remain poorly understood as search continues for the perceived pathogenic protein species. Previously, variants in Superoxide Dismutase 1 (SOD1) causing Amyotrophic Lateral Sclerosis (ALS) were found to destabilize and reduce net charge, suggesting a pathogenic aggregation mechanism. This paper reports analysis...
Kepp, Kasper Planeta
Late-onset neurodegenerative diseases remain poorly understood as search continues for the perceived pathogenic protein species. Previously, variants in Superoxide Dismutase 1 (SOD1) causing Amyotrophic Lateral Sclerosis (ALS) were found to destabilize and reduce net charge, suggesting a pathogenic aggregation mechanism. This paper reports analysis...
Mikalsen, Theresa Pedersen, Torunn Willems, Rob Coque, Teresa M. Werner, Guido Sadowy, Ewa van Schaik, Willem Jensen, Lars Bogø Sundsfjord, Arnfinn Hegstad, Kristin
...
Background: The success of Enterococcus faecium and E. faecalis evolving as multi-resistant nosocomial pathogens is associated with their ability to acquire and share adaptive traits, including antimicrobial resistance genes encoded by mobile genetic elements (MGEs). Here, we investigate this mobilome in successful hospital associated genetic linea...
Mikalsen, Theresa Pedersen, Torunn Willems, Rob Coque, Teresa M. Werner, Guido Sadowy, Ewa van Schaik, Willem Jensen, Lars Bogø Sundsfjord, Arnfinn Hegstad, Kristin
...
Background: The success of Enterococcus faecium and E. faecalis evolving as multi-resistant nosocomial pathogens is associated with their ability to acquire and share adaptive traits, including antimicrobial resistance genes encoded by mobile genetic elements (MGEs). Here, we investigate this mobilome in successful hospital associated genetic linea...
So, Jonathan Pasculescu, Adrian Dai, Anna Y. Williton, Kelly James, Andrew Nguyen, Vivian Creixell, Pau Schoof, Erwin M. Sinclair, John Barrios-Rodiles, Miriam
...
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is an endogenous secreted peptide and, in preclinical studies, preferentially induces apoptosis in tumor cells rather than in normal cells. The acquisition of resistance in cells exposed to TRAIL or its mimics limits their clinical efficacy. Because kinases are intimately involved in t...
So, Jonathan Pasculescu, Adrian Dai, Anna Y. Williton, Kelly James, Andrew Nguyen, Vivian Creixell, Pau Schoof, Erwin M. Sinclair, John Barrios-Rodiles, Miriam
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Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is an endogenous secreted peptide and, in preclinical studies, preferentially induces apoptosis in tumor cells rather than in normal cells. The acquisition of resistance in cells exposed to TRAIL or its mimics limits their clinical efficacy. Because kinases are intimately involved in t...
Kepp, Kasper Planeta
Late-onset neurodegenerative diseases remain poorly understood as search continues for the perceived pathogenic protein species. Previously, variants in Superoxide Dismutase 1 (SOD1) causing Amyotrophic Lateral Sclerosis (ALS) were found to destabilize and reduce net charge, suggesting a pathogenic aggregation mechanism. This paper reports analysis...
Mikalsen, Theresa Pedersen, Torunn Willems, Rob Coque, Teresa M. Werner, Guido Sadowy, Ewa van Schaik, Willem Jensen, Lars Bogø Sundsfjord, Arnfinn Hegstad, Kristin
...
Background: The success of Enterococcus faecium and E. faecalis evolving as multi-resistant nosocomial pathogens is associated with their ability to acquire and share adaptive traits, including antimicrobial resistance genes encoded by mobile genetic elements (MGEs). Here, we investigate this mobilome in successful hospital associated genetic linea...