chih-ching, li lin, chih-chien lee, chun-yi sheu, meei-ling tsai, yi-ching tsai, chia-yun hao-ting, wu ren-jang, wu lai, de-wei
The individual ingredients of 1,3-Propanediol, Soline, and Fucocert® (PSF) are often used as cosmetic formulations in skin care. In addition, the mixture of Lecigel, Cetiol®CC, Activonol-6, and Activonol-M (LCAA) is often used as a cosmetic base. However, whether the combination of LCAA with PSF (LCAA-PSF) exerts a therapeutic effect on psoriasis r...
Wang, Yanxia Wan, Zijian Zhu, Yueting Hu, Haibo Jiang, Yujia Jiang, Wankui Zhang, Wenming Xin, Fengxue
Published in
Biotechnology for Biofuels and Bioproducts
Background 1,3-Propanediol (1,3-PDO) is a platform compound, which has been widely used in food, pharmaceutical and cosmetic industries. Compared with chemical methods, the biological synthesis of 1,3-PDO has shown promising applications owing to its mild conditions and environmental friendliness. However, the biological synthesis of 1,3-PDO still ...
Zhang, Yufei Yun, Junhua Zabed, Hossain M Dou, Yuan Zhang, Guoyan Zhao, Mei Taherzadeh, Mohammad J Ragauskas, Arthur Qi, Xianghui
Published in
Bioresource technology
3-Hydroxypropionic acid (3-HP) and 1,3-propanediol (1,3-PDO) are value-added chemicals with versatile applications in the chemical, pharmaceutical, and food industries. Nevertheless, sustainable production of 3-HP and 1,3-PDO is often limited by the lack of efficient strains and suitable fermentation configurations. Herein, attempts have been made ...
Zhang, Ye Liu, Dehua Chen, Zhen
Published in
Methods in molecular biology (Clifton, N.J.)
The fastest-growing bacterium Vibrio natriegens is a highly promising next-generation workhorse for molecular biology and industrial biotechnology. In this work, we described the workflows for developing genome-scale metabolic models and genome-editing protocols for engineering Vibrio natriegens. A case study for metabolic engineering of Vibrio nat...
Wang, Xiao-Li Zhou, Jin-Jie Liu, Sheng Sun, Ya-Qin Xiu, Zhi-Long
Published in
Biotechnology for Biofuels and Bioproducts
Background Climate change caused by greenhouse gas emission has become a global hot topic. Although biotechnology is considered as an environmentally friendly method to produce chemicals, almost all biochemicals face carbon dioxide emission from inevitable respiration and energy metabolism of most microorganisms. To cater for the broad prospect of ...
Li, Zihua Dong, Yufei Liu, Yu Cen, Xuecong Liu, Dehua Chen, Zhen
Published in
Metabolic engineering
Corynebacterium glutamicum is a versatile chassis which has been widely used to produce various amino acids and organic acids. In this study, we report the development of an efficient C. glutamicum strain to produce 1,3-propanediol (1,3-PDO) from glucose and xylose by systems metabolic engineering approaches, including (1) construction and optimiza...
Zhang, Ye Li, Zihua Liu, Yu Cen, Xuecong Liu, Dehua Chen, Zhen
Published in
Metabolic engineering
The economic viability of current bio-production systems is often limited by its low productivity due to slow cell growth and low substrate uptake rate. The fastest-growing bacterium Vibrio natriegens is a highly promising next-generation workhorse of the biotechnology industry which can utilize various industrially relevant carbon sources with hig...
Yun, Junhua Zabed, Hossain M Zhang, Yufei Parvez, Amreesh Zhang, Guoyan Qi, Xianghui
Published in
Bioresource technology
The necessity of costly co-enzyme B12 for the activity of glycerol dehydratase (GDHt) is considered as a major bottleneck in sustainable bioproduction of 1,3-propanediol (1,3-PD) from glycerol. Here, an E. coil Rosetta-dhaB1-dhaB2 strain was constructed by overexpressing a B12-independent GDHt (dhaB1) and its activating factor (dhaB2) from Clostrid...
Zhou, Jin-Jie Shen, Jun-Tao Wang, Xiao-Li Sun, Ya-Qin Xiu, Zhi-Long
Published in
Biotechnology for Biofuels
BackgroundOscillation is a special cell behavior in microorganisms during continuous fermentation, which poses threats to the output stability for industrial productions of biofuels and biochemicals. In previous study, a spontaneous oscillatory behavior was observed in Clostridium butyricum-intensive microbial consortium in continuous fermentation ...
Mojarrad, Mohammad Hirai, Keisuke Fuki, Koji Tajima, Takahisa Hida, Akiko Kato, Junichi
Published in
Journal of biotechnology
1,3-Propanediol (1,3-PDO) is a valuable compound with a large potential market in many industries. This study aimed to evaluate the abilities of the Psychrophile-based Simple bioCatalyst (PSCat) reaction system to biosynthesize 1,3-PDO. This biocatalyst has a potential platform that replaces the chemical-based production counterparts. The two genes...
