Wu, Wei Lu, Qun Ma, Shan Du, Jin-Chan Huynh, Kevin Duong, Thy Pang, Zhang-Da Donner, Daniel Meikle, Peter J Deng, Xiu-Ling
...
Published in
American journal of physiology. Heart and circulatory physiology
Takotsubo syndrome (TTS) is characterized by short-term contractile dysfunction with its mechanism undefined. We showed that activation of cardiac Hippo pathway mediates mitochondrial dysfunction and that stimulation of β-adrenoceptors (βAR) activates Hippo pathway. Here, we investigated the role of βAR-Hippo signaling in mediating mitochondrial dy...
Wu, Siyuan Ootawa, Tomoki Sekio, Ryoya Smith, Henry Islam, Md. Zahorul Uno, Yasuhiro Shiraishi, Mitsuya Miyamoto, Atsushi
Published in
Poultry Science
The response of basilar arteries to noradrenaline varies among many animal species, but remains little studied in poultry. Accordingly, we aimed to characterize the adrenergic receptor ( AR ) subtypes that modulate vascular response in basilar arteries in the chicken, with isometric recording of arterial ring tension using an organ bath. We demonst...
Fan, Frank S
Published in
Nutrition and health
Background: The overall prevalence of diabetes in the world has risen substantially in the past several decades, so have complications and mortalities associated with it. Aim: Prevention strategies for diabetes thus become an urgent public health need for reducing the burden of diabetes. Methods: Ractopamine, a β1/2-adrenergic receptor agonist, has...
Cui, Shishuang Fang, Fang Cui, Peijing Jiang, Qianwen Xu, Shaoqing Xu, Zhihong Hu, Jia'An Li, Feika
Published in
Frontiers in Neurology
Objective Age-related decline within the noradrenergic system is associated with reduced cognition. The β-adrenoceptors are widely expressed in the brain as well as in the peripheral. Medications targeting β-adrenoceptor activity have been widely used in older adults. The aim of this study was to explore the associations between β-adrenoceptor acti...
Qi, Yue-Hong Yang, Lu-Zi Zhou, Lan Gao, Li-Juan Hou, Jia-Yi Yan, Zi Bi, Xiao-Gang Yan, Cai-Ping Wang, De-Ping Cao, Ji-Min
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Published in
Heliyon
This study aimed to address the status, role, and mechanism of sympathetic nerve infiltration in the progression of stomach adenocarcinoma (STAD). Sympathetic nerve and its neurotransmitter NE, β-ARs, and associated signaling molecules in the STAD tissues and the adjacent tissues from 46 STAD patients were examined using immunostaining, HPLC, and w...
Efimov, Alexander V Meshcheryakova, Olga V Ryazanov, Alexey G
Published in
Biochemistry. Biokhimiia
In this study, we conducted a comparative analysis of the structure of agonists and antagonists of transmembrane (TM) β-adrenoceptors (β-ARs) and their interactions with the β-ARs and proposed the mechanism of receptor activation. A characteristic feature of agonist and antagonist molecules is the presence of a hydrophobic head (most often, one or ...
Esmaeeli, Abdolhamid Keshavarz, Zahra Dehdar, Firoozeh Assadi, Majid Seyedabadi, Mohammad
Published in
Drug and chemical toxicology
The β-adrenoceptor blockers may have anti-oxidant properties or induce β-arrestin recruitment beyond classical desensitization of receptor/G protein coupling, offering potential therapeutic benefits. Here, we investigated the effects of carvedilol, metoprolol and propranolol in an animal model of cisplatin-induced nephrotoxicity. Rats received the ...
Wragg, Edward S Pannucci, Patrizia Hill, Stephen J Woolard, Jeanette Cooper, Samantha L
Published in
Pharmacology research & perspectives
A2A and A2B adenosine receptors produce regionally selective regulation of vascular tone and elicit differing effects on mean arterial pressure (MAP), whilst inducing tachycardia. The tachycardia induced by the stimulation of A2A or A2B receptors has been suggested to be mediated by a reflex increase in sympathetic activity. Here, we have investiga...
Huang, Lishan Chen, Zhou Chen, Ruiyu Lin, Lu Ren, Lingjia Zhang, Meilian Liu, Libin
Published in
Redox biology
The mechanism of severe hypoglycemia (SH)-induced cardiovascular disease in diabetes remains unknown. Our previous study found that SH inhibits cardiac function and lipid metabolism in diabetic mice. Conversely, in nondiabetic mice, SH does not induce cardiac dysfunction but promotes cardiac lipid metabolism. This study aims to clarify the effect o...
Lim, Iris Chess-Williams, Russ
Published in
Naunyn-Schmiedeberg's Archives of Pharmacology
The β3-agonist mirabegron is thought to induce relaxation of the detrusor muscle, contributing to the improvement of overactive bladder symptoms. There has been recent interest in purposing mirabegron as a medical expulsive therapy drug to improve the passage of smaller kidney stones by relaxing the ureteral smooth muscles. The aim of this study wa...
