Pagès, Mélanie Beccaria, Kevin Boddaert, Nathalie Saffroy, Raphaël Besnard, Aurore Castel, David Fina, Frédéric Barets, Doriane Barret, Emilie Lacroix, Ludovic
...
Published in
Brain pathology (Zurich, Switzerland)
Ganglioglioma (GG) is a grade I tumor characterized by alterations in the MAPK pathway, including BRAF V600E mutation. Recently, diffuse midline glioma with an H3 K27M mutation was added to the WHO 2016 classification as a new grade IV entity. As co-occurrence of H3 K27M and BRAF V600E mutations has been reported in midline tumors and anaplastic GG...
Paquet, Claire Boche, Delphine Bouchtaoui, Morad El Gourmaud, Sarah Anne Janin Bousquet, Guilhem
Published in
Neuropathology
International audience
Kraeber-Bodéré, Françoise Pallardy, Amandine Maisonneuve, Hervé Campion, Loïc Moreau, Anne Soubeyran, Isabelle Le Gouill, Steven Tournilhac, Olivier Daguindau, Etienne Jardel, Henry
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BACKGROUND: Radioimmunotherapy represents a potential option as consolidation after chemoimmunotherapy in patients with diffuse large B-cell lymphoma who are not candidates for transplantation. We aimed to assess activity and toxicity of fractionated radioimmunotherapy using anti-CD22 (90)Y-epratuzumab tetraxetan as consolidation after front-line i...
Romero, Martha Gapihan, Guillaume Castro-Vega, Luis Jaime Acevedo, Andrés Wang, Li Wei Li, Zhao Bouchtaoui, Morad El Benedetto, Mélanie Di Ratajczak, Philippe Feugeas, Jean-Paul
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Published in
Oncotarget
Background: Primary mediastinal large B-cell lymphoma (PMBL) shares pathological features with diffuse large B-cell lymphoma (DLBCL), and molecular features with classical Hodgkin lymphoma (cHL). The miR-17~92 oncogenic cluster, located at chromosome 13q31, is a region that is amplified in DLBCL.Methods: Here we compared the expression of each memb...
Hadjadj, Djihad Denecker, Thomas Maric, Chrystelle Fauchereau, Fabien Giuseppe Baldacci Cadoret, Jean-Charles
Published in
Genomics Data
During the S-phase, the DNA replication process is finely orchestrated and regulated by two programs: the spatial program that determines where replication will start in the genome (Cadoret et al. (2008 Oct 14), Cayrou et al. (2011 Sep), Picard et al. (2014 May 1) [1], [2], [3]), and the temporal program that determines when during the S phase diff...
Désert, Romain Mebarki, Sihem Desille, Mireille Sicard, Marie Lavergne, Elise Renaud, Stéphanie Bergeat, Damien Sulpice, Laurent Christine Perret Turlin, Bruno
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Published in
The International Journal of Biochemistry & Cell Biology
Hepatocellular carcinoma (HCC) is the 3rd cause of cancer-related death worldwide. Most cases arise in a background of chronic inflammation, extracellular matrix (ECM) remodeling, severe fibrosis and stem/progenitor cell amplification. Although HCCs are soft cellular tumors, they may contain fibrous nests within the tumor mass. Thus, the aim of thi...
Hardonnière, Kevin Saunier, Elise Lemarié, Anthony Fernier, Morgane Gallais, Isabelle Helies-Toussaint, Cecile Mograbi, Baharia Antonio, Samantha Bénit, Paule Pierre Rustin
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Published in
Scientific Reports
Cancer cells display alterations in many cellular processes. One core hallmark of cancer is the Warburg effect which is a glycolytic reprogramming that allows cells to survive and proliferate. Although the contributions of environmental contaminants to cancer development are widely accepted, the underlying mechanisms have to be clarified. Benzo[a]p...
Olivier Hermine Hoster, Eva Walewski, Jan Bosly, André Stilgenbauer, Stephan Thieblemont, Catherine Szymczyk, Michal Bouabdallah, Reda Kneba, Michael Hallek, Michael
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Published in
The Lancet
Background: Mantle cell lymphoma is characterised by a poor long-term prognosis. The European Mantle Cell Lymphoma Network aimed to investigate whether the introduction of high-dose cytarabine to immunochemotherapy before autologous stem-cell transplantation (ASCT) improves outcome.
Methods: This randomised, open-label, parallel-group, phase 3 t...
Bachy, Emmanuel Urb, Mirjam Chandra, Shilpi Robinot, Rémy Bricard, Gabriel De Bernard, Simon Traverse-Glehen, Alexandra Gazzo, Sophie Blond, Olivier Khurana, Archana
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Published in
Journal of Experimental Medicine
Peripheral T cell lymphomas (PTCLs) are a heterogeneous entity of neoplasms with poor prognosis, lack of effective therapies, and a largely unknown pathophysiology. Identifying the mechanism of lymphomagenesis and cell-of-origin from which PTCLs arise is crucial for the development of efficient treatment strategies. In addition to the well-describe...
Hanini, Amel Massoudi, Mohamed El Gavard, Julie Kacem, Kamel Souad Ammar Souilem, Ouajdi
Published in
Environmental Toxicology and Pharmacology
The increasing use of engineered nanomaterials in commercial manufacturing and consumer products presents an important toxicological concern. Superparamagnetic zinc-cobalt ferrite nanoparticles (SFN) emerge as a promising tool for early cancer diagnostics and targeted therapy. However, toxicity and biological activities of SFN should be evaluated i...
