Orcel, Philippe Partouche, Henri Personne, Virginie Pierrot-Deseilligny, Charles Polak, Michel Pouteil-Noble, Claire Prié, Dominique Raynaud-Simon, Agathe Rolland, Yves Sadoul, Jean-Louis
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Published in
Gériatrie et Psychologie Neuropsychiatrie du Viellissement
The number of serum 25-hydroxyvitamin D (25OHD) assays has increased tenfold in France in less than 10 years, sometimes for invalidated reasons. In 2013, the French National Authority for Health (Haute autorité de santé, or HAS) limited the indications for serum 25OHD measurements to rickets/osteomalacia, older adults with recurrent falls, monitori...
Fieulaine, Sonia Alves De Sousa, Rodolphe Maigre, Laure Hamiche, Karim Alimi, Mickael Bolla, Jean-Michel Taleb, Abbass Denis, Alexis Pagès, Jean-Marie Isabelle Artaud
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Published in
Scientific Reports
Peptide deformylase (PDF) is considered an excellent target to develop antibiotics. We have performed an extensive characterization of a new PDF from the pathogen Streptococcus agalactiae, showing properties similar to other known PDFs. S. agalactiae PDF could be used as PDF prototype as it allowed to get complete sets of 3-dimensional, biophysical...
Laurent, Marie-Amandine Bonnier, Dominique Nathalie Théret Pierre Tuffery Moroy, Gautier
Published in
Computational Biology and Chemistry
Metalloproteases involved in extracellular matrix remodeling play a pivotal role in cell response by regulating the bioavailability of cytokines and growth factors. Recently, the disintegrin and metalloprotease, ADAMTS1 has been demonstrated to be able to activate the transforming growth factor TGF-β, a major factor in fibrosis and cancer. The KTFR...
Lefèvre-Colau, Marie-Martine Nguyen, Christelle Haddad, Rebecca Delamarche, Paul Paris, Guillaume Palazzo, Clémence Poiraudeau, Serge Rannou, François Roren, Alexandra
Published in
Annals of physical and rehabilitation medicine
In this critical narrative review, we examine the role of physical activity (PA), recreational and elite sports in the development of knee/hip osteoarthritis (OA), taking into account the role of injury in this relationship. The process of article selection was unsystematic. Articles were selected on the basis of the authors' expertise, self-knowle...
Sakanyan, Vehary Hulin, Philippe Sousa, Rodolphe Silva, Viviane A. O. Hambardzumyan, Artur Nedellec, Steven Tomasoni, Christophe Logé, Cédric Charles Pineau Roussakis, Christos
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Published in
Scientific Reports
Activation of cell signaling by reactive chemicals and pollutants is an important issue for human health. It has been shown that lipophilic nitro-benzoxadiazole (NBD) compounds rapidly move across the plasma membrane and enhance Epidermal Growth Factor Receptor (EGFR) tyrosine phosphorylation in cancer cells. Unlike ligand-dependent activation, the...
Brureau, Laurent Moningo, Dieudonné Emeville, Elise Ferdinand, Séverine Punga, Augustin Lufuma, Simon Blanchet, Pascal Romana, Marc Luc Multigner
BACKGROUND: Estrogens are thought to play a critical role in prostate carcinogenesis. It has been suggested that polymorphisms of genes encoding enzymes involved in estrogen metabolism are risk factors for prostate cancer. However, few studies have been performed on populations of African ancestry, which are known to have a high risk of prostate ca...
Bachy, Emmanuel Urb, Mirjam Chandra, Shilpi Robinot, Rémy Bricard, Gabriel De Bernard, Simon Traverse-Glehen, Alexandra Gazzo, Sophie Blond, Olivier Khurana, Archana
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International audience
Liu, Xiaohui Jia, Xiaoe Yuan, Hao Ma, Ke Chen, Yi Jin, Yi Deng, Min Pan, Weijun Chen, Saijuan Chen, Zhu
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Published in
Journal of Hematology & Oncology
Background
DNA methyltransferase 1 (Dnmt1) regulates expression of many critical genes through maintaining parental DNA methylation patterns on daughter DNA strands during mitosis. It is essential for embryonic development and diverse biological processes, including maintenance of hematopoietic stem and progenitor cells (HSPCs). However, the preci...
Yu, Jinchao Picord, Geraldine Pierre Tuffery Guerois, Raphael
Published in
Bioinformatics
MOTIVATION:
The HHsearch algorithm, implementing a hidden Markov model (HMM)-HMM alignment method, has shown excellent alignment performance in the so-called twilight zone (target-template sequence identity with ∼20%). However, an optimal alignment by HHsearch may contain small to large errors, leading to poor structure prediction if these errors ...
Verger, Emmanuelle Bruno Cassinat Chauveau, Aurélie Christine Dosquet Giraudier, Stephane Schlageter, Marie-Hélène Ianotto, Jean-Christophe Yassin, Mohammed A Al-Dewik, Nader Carillo, Serge
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Published in
Blood
Myeloproliferative neoplasms are clonal disorders characterized by the presence of several gene mutations associated with particular hematologic parameters, clinical evolution, and prognosis. Few therapeutic options are available, among which interferon α (IFNα) presents interesting properties like the ability to induce hematologic responses (HRs) ...
