VGLUT3 gates psychomotor effects induced by amphetamine
International audience
Shadow imaging for panoptical visualization of brain tissue in vivo
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Progress in neuroscience research hinges on technical advances in visualizing living brain tissue with high fidelity and facility. Current neuroanatomical imaging approaches either require tissue fixation (electron microscopy), do not have cellular resolution (magnetic resonance imaging) or only give a fragmented view (fluorescence microscopy). Her...
Premorbid performances determine the deleterious effects of nigrostriatal degeneration and pramipexole on behavioural fl...
Abstract Subtle cognitive impairment can occur early in the course of Parkinson’s disease (PD) and may manifest under different forms of executive dysfunction such as impaired cognitive flexibility. The precise contribution of nigrostriatal dopaminergic neurodegeneration to these non-motor features of the disease is poorly known. Whether such cogni...
Estrogenic regulation of claudin 5 and tight junction protein 1 gene expression in zebrafish: A role on blood-brain barr...
Published in The Journal of comparative neurology
The blood-brain barrier (BBB) is a physical interface between the blood and the brain parenchyma, playing key roles in brain homeostasis. In mammals, the BBB is established thanks to tight junctions between cerebral endothelial cells, involving claudin, occludin, and zonula occludens proteins. Estrogens have been documented to modulate BBB permeabi...
Brain mediators of biased social learning of self-perception in social anxiety disorder
Abstract Social anxiety disorder (SAD) is characterized by an excessive fear of social evaluation and a persistently negative view of the self. Here we test the hypothesis that negative biases in brain responses and in social learning of self-related information contribute to the negative self-image and low self-esteem characteristic of SAD. Adult ...
The CLDN5 gene at the blood-brain barrier in health and disease
Abstract The CLDN5 gene encodes claudin-5 (CLDN-5) that is expressed in endothelial cells and forms tight junctions which limit the passive diffusions of ions and solutes. The blood–brain barrier (BBB), composed of brain microvascular endothelial cells and associated pericytes and end-feet of astrocytes, is a physical and biological barrier to main...
Sensory fusion in the hoverfly righting reflex
We study how falling hoverflies use sensory cues to trigger appropriate roll righting behavior. Before being released in a free fall, flies were placed upside-down with their legs contacting the substrate. The prior leg proprioceptive information about their initial orientation sufficed for the flies to right themselves properly. However, flies als...
Characterizing endogenous delta oscillations in human MEG
Rhythmic activity in the delta frequency range (0.5–3 Hz) is a prominent feature of brain dynamics. Here, we examined whether spontaneous delta oscillations, as found in invasive recordings in awake animals, can be observed in non-invasive recordings performed in humans with magnetoencephalography (MEG). In humans, delta activity is commonly report...
Differential action of TIGIT on islet and peripheral nerve autoimmunity in the NOD mouse
We previously demonstrated that the abrogation of the ICOS pathway prevents type 1 diabetes development in the Non Obese Diabetic (NOD) mouse, but results in a CD4+ T-cell dependent autoimmune neuromyopathy in aged mice. Pancreatic islet infiltrates in conventional NOD mice and neuromuscular infiltrates in Icosl-/- NOD mice have in common that they...
Visual activity enhances neuronal excitability in thalamic relay neurons
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The dorsal lateral geniculate nucleus (dLGN) has long been held to act as a basic relay forvisual information travelling from the retina to cortical areas, but recent findings suggest alargely underestimated functional plasticity of dLGN neurons. However, the cellularmechanisms supporting this functional plasticity have not been yet explored. In pa...
