Souci, Laurent Denesvre, Caroline
This article reviews the avian viruses that infect the skin of domestic farm birds of primary economic importance: chicken, duck, turkey, and goose. Many avian viruses (e.g., poxviruses, herpesviruses, Influenza viruses, retroviruses) leading to pathologies infect the skin and the appendages of these birds. Some of these viruses (e.g., Marek’s dise...
Fitzmeyer, Emily Dutt, Taru Pinaud, Silvain Graham, Barbara Gallichotte, Emily Hill, Jessica Campbell, Corey Ogg, Hunter Howick, Virginia Lawniczak, Mara
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Abstract The mosquito midgut functions as a key interface between pathogen and vector. However, studies of midgut physiology and associated virus infection dynamics are scarce, and in Culex tarsalis – an extremely efficient vector of West Nile virus (WNV) – nonexistent. We performed single-cell RNA sequencing on Cx. tarsalis midguts, defined multip...
Hervet, Caroline Perrin, Aline Renson, Patricia Deblanc, Céline Muñoz, Marta Meurens, François Argilaguet, Jordi Simon, Gaëlle Bourry, Olivier Maisonnasse, Pauline
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Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) strongly impacts the pig rearing sector due to its persistence in infected animals. Interestingly, although the PRRSV family exhibits considerable genome variability, with the PRRSV-1 and PRRSV-2 subtypes having been finally classified in two different species (Betaarterivirus suid 1 and 2...
Roth, Claude Pitard, Bruno Levillayer, Laurine Lay, Sokchea Vo, Hoa Thi My Cantaert, Tineke Sakuntabhai, Anavaj
Zika virus (ZIKV) and dengue virus (DENV) are closely related flaviviruses co-circulating in the same endemic areas. Infection can raise cross-reactive antibodies that can be either protective or increase risk of severe disease, depending on the infection sequence, DENV serotype and elapsed time between infection. On the contrast, T cell-mediated i...
Marcadet-Hauss, Aïlona Gellenoncourt, Stacy Pellerin, Marie Meyer, Léa Grey, Finn Wilson, Sam Roque-Afonso, Anne Marie Pavio, Nicole Doceul, Virginie
Hepatitis E virus (HEV) is a major cause of enterically transmitted viral hepatitis worldwide. Four main genotypes circulate in humans (HEV-1 to -4). HEV-3 and -4 are zoonotic, whereas HEV-1 and -2 circulate only in human. Swine are the main reservoir of zoonotic HEV that is transmitted mainly via the foodborne route. In France, zoonotic HEV repres...
Pellerin, Marie Doceul, Virginie Sauvage, Virginie Gellenoncourt, Stacy Marcadet-Hauss, Aïlona Picard-Meyer, Evelyne Daouda Soro, Sionfoungo Lattard, Virginie Montchatre-Leroy, Elodie Pavio, Nicole
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The Hepeviridae family, whose prototype virus is hepatitis E virus (HEV), comprises several viral species whose host range are not yet well defined. The emergence of cases of acute or chronic hepatitis in humans following infection with rat hepatitis E virus is a cause for concern, and there is a need to acquire new knowledge of the geographicaldis...
Sicard, Anne Alalout, Meryem Vigne, Emmanuelle Lemaire, Olivier
Cross-protection is a virus-virus antagonistic interaction well-known from plant virologists as it has been used for decades to prevent viral diseases for several plant species. It consists in infecting a plant with a primary virus in order to prevent (or interfere with) its subsequent infection by a genetically related virus1. A key parameter of t...
Frétaud, Maxence Mehraz, Manon Rousselot, Sébastien Perronet, Karen Marquier, François Langevin, Christelle
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Dellicour, Simon Bastide, Paul Rocu, Pauline Fargette, Denis Hardy, Olivier Suchard, Marc Guindon, Stéphane Lemey, Philippe
Abstract Genomic data collected from viral outbreaks can be exploited to reconstruct the dispersal history of viral lineages in a two-dimensional space using continuous phylogeographic inference. These spatially explicit reconstructions can subsequently be used to estimate dispersal metrics allowing to unveil the dispersal dynamics and evaluate the...
Bessenay, Alexandra Bisio, Hugo Belmudes, Lucid Couté, Yohann Bertaux, Lionel Claverie, Jean-Michel Abergel, Chantal Jeudy, Sandra Legendre, Matthieu
Hyperparasitism is a common pattern in nature that is not limited to cellular organisms. Giant viruses infecting protists can be hyperparasitized by smaller ones named virophages. In addition, both may carry episomal DNA molecules known as transpovirons in their particles. They all share transcriptional regulatory elements that dictate the expressi...