Hu, Jingyuan Zhang, Liyue Chen, Mingxuan Dai, Jinyue Teng, Na Zhao, Hongchi Ba, Xinwu Liu, Xiaoqing
Published in
Polymers
To overcome the high flammability and brittleness of epoxy resins without sacrificing their glass transition temperature (Tg) and mechanical properties, three epoxy-terminated hyperbranched flame retardants (EHBFRs) with a rigid central core and different branches, named EHBFR-HB, EHBFR-HCM, and EHBFR-HBM, were synthesized. After chemical structure...
Battelino, Tadej Alexander, Charles Amiel, Stephanie Arreaza-Rubin, Guillermo Beck, Roy Bergenstal, Richard Buckingham, Bruce Carroll, James Ceriello, Antonio Chow, Elaine
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Randomised controlled trials and other prospective clinical studies for novel medical interventions in people with diabetes have traditionally reported HbA1c as the measure of average blood glucose levels for the 3 months preceding the HbA1c test date. The use of this measure highlights the long-established correlation between HbA1c and relative ri...
Wargny, Matthieu Croyal, Mikaël Ragot, Stéphanie Gand, Elise Jacobi, David Trochu, Jean-Noël Prieur, Xavier Le May, Cédric Goronflot, Thomas Cariou, Bertrand
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Published in
Cardiovascular diabetology
Heart failure (HF) is a growing complication and one of the leading causes of mortality in people living with type 2 diabetes (T2D). Among the possible causes, the excess of red meat and the insufficiency of vegetables consumption are suspected. Such an alimentation is associated with nutritional biomarkers, including trimethylamine N-oxide (TMAO) ...
Dantan, Etienne Pailler, Maxime Ragot, Stéphanie Gand, Elise Trochu, Jean-Noel Cariou, Bertrand Saulnier, Pierre-Jean Hadjadj, Samy
Published in
Diabetes research and clinical practice
For type 2 diabetes persons, we assessed the association between renal function decline and heart failure hospitalisation (HFH) and validated dynamic HFH predictions (DynHFH) based on repeated estimated Glomerular Filtration Rate (eGFR) values. We studied 1413 patients from the SURDIAGENE cohort. From a joint model for longitudinal CKD-EPI measures...
Roubtsova, Anna Garçon, Damien Lacoste, Sandrine Chamberland, Ann Marcinkiewicz, Jadwiga Métivier, Raphaël Sotin, Thibaud Paquette, Martine Bernard, Sophie Cariou, Bertrand
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International audience
Mathieu, Meunier Friedrich, Chloé Ducrot, Nicolas Zannoni, Johanna Sylvie, Tondeur Jerraya, Nelly Rousseaux, Sophie Chuffart, Florent Kosmider, Olivier Karim, Zoubida
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Published in
Annals of hematology
In low-risk myelodysplastic syndrome (LR-MDS), erythropoietin (EPO) is widely used for the treatment of chronic anemia. However, initial response to EPO has time-limited effects. Luspatercept reduces red blood cell transfusion dependence in LR-MDS patients. Here, we investigated the molecular action of luspatercept (RAP-536) in an in vitro model of...
Croyal, Mikaël Wargny, Matthieu Chemello, Kevin Chevalier, Chloé Blanchard, Valentin Bigot-Corbel, Edith Lambert, Gilles Le May, Cédric Hadjadj, Samy Cariou, Bertrand
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Published in
Cardiovascular Diabetology
BackgroundThe identification of circulating biomarkers associated with the risk of type 2 diabetes (T2D) is useful for improving the current prevention strategies in the most at-risk patients. Here, we aimed to investigate the association of plasma apolipoprotein concentrations in prediabetes subjects with the incidence of new-onset T2D during foll...
Le Floch, Edith Cosentino, Teresa Larsen, Casper Beuschlein, Felix Reincke, Martin Amar, Laurence Rossi, Gian-Paolo de Sousa, Kelly Baron, Stéphanie Chantalat, Sophie
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Abstract Primary aldosteronism affects up to 10% of hypertensive patients and is responsible for treatment resistance and increased cardiovascular risk. Here we perform a genome-wide association study in a discovery cohort of 562 cases and 950 controls and identify three main loci on chromosomes 1, 13 and X; associations on chromosome 1 and 13 are ...
Gasparics, Ákos Sebe, Attila
Published in
Cancers
Epithelial-mesenchymal transition (EMT) is a process of cellular plasticity regulated by complex signaling networks. Under physiological conditions, it plays an important role in wound healing and organ repair. Its importance for human disease is given by its central role in chronic fibroproliferative diseases and cancer, which represent leading ca...
Marcozzi, Serena Beltrami, Antonio Paolo Malavolta, Marco
Published in
Cells
Cellular senescence is a state of irreversible cell cycle arrest in response to several stressors, including DNA damage, increased cellular oxidative stress, telomere shortening, oncogene activation, and a deep epigenetic remodeling [...].
