In Vivo Medulloblastoma Modeling
International audience
Contribution of imaging-genetics to overall survival prediction compared to clinical status for PCNSL patients
Accurately predicting the survival of patients with cancer has the potential to substantially enhance and customize the treatment strategies. Integrating and using all the patients' available data is essential to make the most accurate predictions. In this work, we gather clinical, imaging and genetic data into one mono-block multivariate survival ...
Rovalpituzumab Tesirine as a Maintenance Therapy Following First-Line Platinum-Based Chemotherapy in Patients With Exten...
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INTRODUCTION: Rovalpituzumab tesirine (Rova-T) is an antibody-drug conjugate targeting delta-like protein 3 (DLL3), an atypical Notch ligand expressed in small cell lung cancer (SCLC) tumors. We evaluated the efficacy of Rova-T versus placebo as maintenance therapy in patients with extensive stage (ES) SCLC after platinum-based chemotherapy. METHOD...
Narrow resection margins are not associated with mortality or recurrence in patients with Merkel cell carcinoma: a retro...
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Background: Wide local excision constitutes the standard of care for Merkel cell carcinoma, but the optimal margin width remains controversial.Objectives: To assess whether narrow margins (0.5 - 1 cm) were associated with outcome.Methods: Patients were recruited from a retrospective French multicentric cohort and included if they had had excision o...
In depth investigation of collagen non-enzymatic glycation by Raman spectroscopy.
Published in Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Non-enzymatic glycation is a post-translational modification of long-lived matrix proteins such as type I collagen. It occurs during aging and leads to the formation of advanced glycation end-products (AGEs). AGE accumulation is associated with severe complications in chronic and age-related diseases. The assessment of modifications induced by this...
Panel gene profiling of small bowel adenocarcinoma, results from the NADEGE prospective cohort
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Small bowel adenocarcinoma (SBA) is a rare tumour. Large genomic analyses with prognostic assessments are lacking. The NADEGE cohort has enrolled 347 patients with all stage SBA from 2009 to 2012. Next generation sequencing investigates the presence of 740 hotspot somatic mutations in a panel of 46 genes involved in carcinogenesis. The mismatch rep...
Patients with Metastatic Melanoma Receiving Anticancer Drugs: Changes in Overall Survival, 2010-2017.
...Published in The Journal of investigative dermatology
Immune checkpoint inhibitors and targeted therapies have profoundly altered the management of several cancers over the past decade. Metastatic melanoma has been at the forefront of these changes. We provide here a nationwide overview and an assessment of changes in survival in France. We included 10,936 patients receiving a systemic treatment for m...
The Relationship between Fatigue and Actigraphy-Derived Sleep and Rest–Activity Patterns in Cancer Survivors
International audience
Multimodal management of surgery- and radiation-refractory meningiomas: an analysis of the French national tumor board m...
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PURPOSE: Meningiomas represent the most frequent tumor of the central nervous system in adults. While most meningiomas are efficiently treated by surgery and radiotherapy/radiosurgery, there is a small portion of radiation- and surgery-refractory tumors for which there is no clear recommendation for optimal management. The French National Tumor Boa...
A robust enzyme-linked immunosorbent assay to measure serum ramucirumab concentrations
Aim: Ramucirumab, an anti-VEGFR2 monoclonal antibody, has been approved for the treatment of metastatic gastric and colorectal cancer. An assay measuring ramucirumab serum concentrations was needed to investigate its pharmacokinetics and concentration-response relationship. Results: An ELISA was developed and validated according to the internationa...
