Grinda, Thomas Joyon, Natacha Lusque, Amélie Lefèvre, Sarah Arnould, Laurent Penault-Llorca, Frédérique Macgrogan, Gaëtan Treilleux, Isabelle Vincent-Salomon, Anne Haudebourg, Juliette
...
Published in
npj Breast Cancer
Expression of hormone receptor (HR) for estrogens (ER) and progesterone (PR) and HER2 remains the cornerstone to define the therapeutic strategy for breast cancer patients. We aimed to compare phenotypic profiles between matched primary and metastatic breast cancer (MBC) in the ESME database, a National real-life multicenter cohort of MBC patients....
Leduc, Alexandre Chaouni, Samia Pouzoulet, Frédéric De Marzi, Ludovic Megnin-Chanet, Frédérique Corre, Erwan Stefan, Dinu Habrand, Jean-Louis Sichel, François Laurent, Carine
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Published in
Scientific Reports
Proton therapy allows to avoid excess radiation dose on normal tissues. However, there are some limitations. Indeed, passive delivery of proton beams results in an increase in the lateral dose upstream of the tumor and active scanning leads to strong differences in dose delivery. This study aims to assess possible differences in the transcriptomic ...
Turnell, Biz R. Kumpitsch, Luisa Ribou, Anne-Cécile Reinhardt, Klaus
Published in
BMC Research Notes
ObjectiveSperm ageing has major evolutionary implications but has received comparatively little attention. Ageing in sperm and other cells is driven largely by oxidative damage from reactive oxygen species (ROS) generated by the mitochondria. Rates of organismal ageing differ across species and are theorized to be linked to somatic ROS levels. Howe...
Enrico Bena, Chiara Del Giudice, Marco Grob, Alice Gueudré, Thomas Miotto, Mattia Gialama, Dimitra Osella, Matteo Turco, Emilia Ceroni, Francesca De Martino, Andrea
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Published in
Scientific Reports
Individual cells exhibit specific proliferative responses to changes in microenvironmental conditions. Whether such potential is constrained by the cell density throughout the growth process is however unclear. Here, we identify a theoretical framework that captures how the information encoded in the initial density of cancer cell populations impac...
Guilleron, Céline Abraham, Pierre Beaune, Bruno Pouliquen, Camille Henni, Samir Durand, Sylvain
Published in
Scientific Reports
The ways in which locations of ischemia and ischemic pain affect spatiotemporal gait parameters and leg electromyographic activity during walking have never been investigated in patients with peripheral arterial disease presenting intermittent claudication. Two groups were classified according to unilateral location of ischemia (distal, n = 10, or ...
Mirabal-Ortega, Liliana Larcher, Magalie Morabito, Morgane Foray, Chloé Duvillié, Bertrand Eychène, Alain Pouponnot, Celio
International audience
Cano, Luis Bertani, Stéphane Island, Marie-Laure Cerapio, Juan Pablo Ruiz, Eloy Pineau, Pascal Monbet, Valérie Boudjema, Karim Taxa, Luis Casavilca-Zambrano, Sandro
...
Published in
Scientific Reports
We have previously described a form of hepatocellular carcinoma (HCC) in non-cirrhotic liver (HCC-NC) developed by Peruvian patients. We analyzed the metallomic profile in hepatic tissues from two independent cohorts exhibiting HCC-NC. Clinical, histopathological data, and HCC and non-tumoral liver (NTL) samples of 38 Peruvian and 38 French HCC-NC ...
Beitone, Clément Fiard, Gaëlle Troccaz, Jocelyne
Published in
Medical physics
Performing a transrectal ultrasound (TRUS) prostate biopsy is at the heart of the current prostate cancer detection procedure. With today's two-dimensional (2D) live ultrasound (US) imaging equipment, this task remains complex due to the poor visibility of cancerous tissue on TRUS images and the limited anatomical context available in the 2D TRUS p...
Guy, Jean-Baptiste Espenel, Sophie Louati, Safa Gauthier, Arnaud Garcia, Max-Adrien Vial, Nicolas Malésys, Céline Ardail, Dominique Alphonse, Gersende Wozny, Anne-Sophie
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PurposeThe clinical outcome of head and neck squamous cell carcinoma (HNSCC) remains poor, partly due to the presence of resistant cancer stem cells (CSCs) which are responsible of recurrences. CSCs have low EGFR expression and, conversely, overexpress the anti-apoptotic Bcl-2 protein, which is involved in resistance to apoptosis and the invasion/m...
Gallois, Claire Emile, Jean-François Kim, Stefano Monterymard, Carole Gilabert, Marine Bez, Jérémie Lièvre, Astrid Dahan, Laetitia Laurent-Puig, Pierre Mineur, Laurent
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Pembrolizumab, a PD1 immune checkpoint inhibitor (ICI), was recently reported to be very effective in patients with microsatellite instable/deficient mismatch repair metastatic colorectal cancer (MSI/dMMR mCRC), unlike patients with microsatellite stable/proficient MMR (MSS/pMMR) mCRC, in whom ICIs are generally ineffective. However, about 15% of M...
