Prouteau, Anaïs Denis, Jérôme Alexandre De Fornel, Pauline Cadieu, Edouard Derrien, Thomas Kergal, Camille Botherel, Nadine Ulvé, Ronan Rault, Mélanie Bouzidi, Amira
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Published in
Scientific Reports
Circulating tumor DNA (ctDNA) has become an attractive biomarker in human oncology, and its use may be informative in canine cancer. Thus, we used droplet digital PCR or PCR for antigen receptor rearrangement, to explore tumor-specific point mutations, copy number alterations, and chromosomal rearrangements in the plasma of cancer-affected dogs. We...
Safieddine, Adham Coleno, Emeline Salloum, Soha Imbert, Arthur Traboulsi, Abdel-Meneem Kwon, Oh Sung Lionneton, Frederic Georget, Virginie Robert, Marie-Cécile Gostan, Thierry
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Published in
Nature Communications
Centrosomes function as microtubule organizing centers where several mRNAs accumulate. By employing high-throughput single molecule FISH screening, the authors discover that 8 human mRNAs localize to centrosomes with unique cell cycle dependent patterns using an active polysome targeting mechanism.
Bizouerne, Elise Buitink, Julia Vu, Benoît Ly Vu, Joseph Ly Esteban, Eddi Pasha, Asher Provart, Nicholas Verdier, Jérôme Leprince, Olivier
Published in
BMC Plant Biology
BackgroundDuring maturation seeds acquire several physiological traits to enable them to survive drying and disseminate the species. Few studies have addressed the regulatory networks controlling acquisition of these traits at the tissue level particularly in endospermic seeds such as tomato, which matures in a fully hydrated environment and does n...
Gauthier, Mélanie Laroye, Caroline Bensoussan, Danièle Boura, Cédric Decot, Veronique
Monoclonal antibodies targeting tumors are one of the most important discoveries in the field of cancer. Although several effective antibodies have been developed, a relapse may occur. One of their mechanisms of action is Antibody Dependent Cell Cytotoxicity (ADCC), by engaging the Fc γ receptor CD16 expressing Natural Killer cells, innate lymphoid...
Velay, Florent Soula, Melanie Mehrez, Marwa D'Alessandro, Stefano Laloi, Christophe Crete, Patrice Field, Ben
The bimolecular fluorescence complementation (BiFC) assay has emerged as one of the most popular methods for analysing protein-protein interactions (PPIs) in plant biology. This includes its increasing use as a tool for dissecting the molecular mechanisms of chloroplast function. However, the construction of chloroplast fusion proteins for BiFC can...
Gallot, Yann Bohnert, Kyle
International audience
Bobyk, Laure Tarantini, Adeline Beal, David Veronesi, Giulia Kieffer, Isabelle Motellier, Sylvie Valsami-Jones, Eugenia Lynch, Iseult Jouneaud, Pierre-Henri Pernet-Gallay, Karin
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Silver nanoparticles (Ag-NPs) are widely used as biocides, leading to contamination of the environment and possible adverse effects on humans. Recent studies revealed that the cellular response to acute exposure to Ag-NPs differs from the response to chronic exposure, although we currently lack systematic studies comparing responses to different do...
Vadodaria, Krishna Mendes, Ana Mei, Arianna Racha, Vipula Erikson, Galina Shokhirev, Maxim Oefner, Ruth Heard, Kelly McCarthy, Michael Eyler, Lisa
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Bipolar disorder (BD) is characterized by cyclical mood shifts. Studies indicate that BD patients have a peripheral pro-inflammatory state and alterations in glial populations in the brain. We utilized an in vitro model to study inflammation-related phenotypes of astrocytes derived from induced pluripotent stem cells (iPSCs) generated from BD patie...
Hatte, Guillaume Prigent, Claude Tassan, Jean-Pierre
Cells dividing in the plane of epithelial tissues proceed by polarized constriction of the actomyosin contractile ring, leading to asymmetric ingression of the plasma mem brane. Asymmetric cytokinesis results in the apical positioning of the actomyosin contractile ring and ultimately of the midbody. Studies have indicated that the contractile ring ...
Ayour, Jamal Le Bourvellec, Carine Gouble, Barbara Audergon, Jean-Marc Benichou, Mohamed Renard, Catherine M.G.C.
The changes of texture and cell wall characteristics of apricot were investigated in ten clones at two maturity stages. Fruit firmness, cell wall composition and enzyme activity of three apricot flesh zones were analysed. The AIS (alcohol-insoluble solids) were characterised by high amounts of uronic acid (179-300 mg g-1 AIS) and relatively high am...