Prostate cancer is the most highly diagnosed cancer in men worldwide. It is characterized by high proliferation, great invasion and metastatic potential. Sodium channel subtypes have been identified as highly expressed in different prostate cancer cell lines. In this study, we have screened the negatively charged fractions of Androctonus australis ...
Bundles of actin filaments are central to a large variety of cellular structures such as filopodia, stress fibers, cytokinetic rings, and focal adhesions. The mechanical properties of these bundles are critical for proper force transmission and force bearing. Previous mathematical modeling efforts have focused on bundles' rigidity and shape. Howeve...
Calcium exchanges and homeostasis are finely regulated between cellular organelles and in response to physiological signals. Besides ionophores, including voltage-gated Ca2+ channels, ionotropic neurotransmitter receptors, or Store-operated Ca2+ entry, activity of regulatory intracellular proteins finely tune Calcium homeostasis. One of the most in...
International audience
International audience
Spatially controlled cell adhesion on electron microscopy supports remains a bottleneck in specimen preparation for cellular cryo-electron tomography. Here, we describe contactless and mask-free photo-micropatterning of electron microscopy grids for site-specific deposition of extracellular matrix-related proteins. We attained refined cell position...
International audience
International audience
Chromogranin A (CgA) is a soluble glycoprotein stored with hormones andneuropeptides in secretory granules (SG) of most (neuro)endocrine cells andneurons. Since its discovery in 1967, many studies have reported its structuralcharacteristics, biological roles, and mechanisms of action. Indeed, CgA is botha precursor of various biologically active pe...
Les glioblastomes multiformes (GBM) sont les tumeurs les plus fréquentes et agressives dusystème nerveux central. Le traitement standard des GBM suit le « Protocole de Stupp » quiconsiste en une résection chirurgicale de la tumeur la plus large possible, suivie d’uneradiothérapie/chimiothérapie au temozolomide (TMZ) concomitante. Malgré ce traiteme...
