The formation of protein precursors, due to the condensation of atomic carbon under the low-temperature conditions of the molecular phases of the interstellar medium, opens alternative pathways for the origin of life. We perform peptide synthesis under conditions prevailing in space and provide a comprehensive analytic characterization of its produ...
Le fonctionnement des cellules vivantes est assuré par un ensemble d'interactions entre des molécules que l'on appelle protéines. Identifier les couples de protéines en interaction, impliqués dans un processus biologique d'intérêt, permet donc de mieux comprendre son fonctionnement. Pour cela, il existe un ensemble de méthodes expérimentales, mais ...
International audience
We present a novel approach to modeling receptor-activated signaling pathways that take into account the compartmentalization of receptors and their effectors, both on the cell surface and in dynamic intracellular vesicles called endosomes. The first building block of the model concerns compartment dynamics. It takes into account creation of de nov...
The body plan of the fruit fly is determined by the expression of just a handful of genes. We show that the spatial patterns of expression for several of these genes scale precisely with the size of the embryo. Concretely, discrete positional markers such as the peaks in striped patterns have absolute positions along the anterior-posterior axis tha...
The Turing completeness of continuous Chemical Reaction Networks (CRNs) states that any computable real function can be computed by a continuous CRN on a finite set of molecular species, possibly restricted to elementary reactions, i.e. with at most two reactants and mass action law kinetics. In this paper, we introduce a more stringent notion of r...
In a developing embryo, information about the position of cells is encoded in the concentrations of "morphogen" molecules. In the fruit fly, the local concentrations of just a handful of proteins encoded by the gap genes are sufficient to specify position with a precision comparable to the spacing between cells along the anterior--posterior axis. T...
Le métabolisme est l'ensemble des réactions biochimiques qui ont lieu dans un organisme. La séquence de ces réactions forme les voies métaboliques et leurs interconnexions constituent le réseau métabolique d'un organisme. Les réactions dans le réseau métabolique sont principalement catalysées par des enzymes qui sont classées en fonction de la natu...
Although interactions between academic research and plant breeding companies over the last century have enabled significant progress in crop improvement by producing high-yielding varieties, it has been several years since major crop yields have increased significantly. In addition, according to the Intergovernmental Panel on Climate Change (IPCC),...
Over the past two decades, the systems biology community has dedicated substantial efforts to constructing genome-scale metabolic models (GEMs), which offer detailed representations of an organism's entire metabolism. GEMs present metabolism as a network, linking metabolic reactions and metabolites. Despite their wealth of information, GEMs come wi...
