Which phloem in Cucumis melo is exploited by Aphis gossypii ? / Which phloem in Cucumis melo is exploited by Aphis gossy...
Metatranscriptomics of cheese microbial communities: Efficiency of RNA extraction from various cheese types and of mRNA ...
Microbial communities from cheeses contribute to the development of typical organoleptic properties. Metatranscriptomic analyses can be used to provide a global picture of the functioning of these communities. Our objective was to evaluate the efficiency of RNA extraction from various cheese types and to evaluate mRNA enrichment procedures for meta...
ALDH1L2 Knockout in U251 Glioblastoma Cells Reduces Tumor Sphere Formation by Increasing Oxidative Stress and Suppressin...
Previously, the in vitro growth of cancer stem cells in the form of tumor spheres from five different brain cancer cell lines was found to be methionine-dependent. As this earlier work indicated that ALDH1L2, a folate-dependent mitochondria aldehyde dehydrogenase gene, is upregulated in glioblastoma stem cells, we invalidated this gene using CRISPR...
A genome-wide epistatic network underlies the molecular architecture of continuous color variation of body extremities.
Published in Genomics
Deciphering the molecular architecture of coat coloration for a better understanding of the biological mechanisms underlying pigmentation still remains a challenge. We took advantage of a rabbit French experimental population in which both a pattern and a gradient of coloration from white to brown segregated within the himalayan phenotype. The whol...
Differential gene expression in aphids following virus acquisition from plants or from an artificial medium.
Published in BMC genomics
Poleroviruses, such as turnip yellows virus (TuYV), are plant viruses strictly transmitted by aphids in a persistent and circulative manner. Acquisition of either virus particles or plant material altered by virus infection is expected to induce gene expression deregulation in aphids which may ultimately alter their behavior. By conducting an RNA-S...
Impact of Carbon Source Supplementations on Pseudomonas aeruginosa Physiology
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Pseudomonas aeruginosa is an opportunistic pathogen highly resistant to a wide range of antimicrobial agents, making its infections very difficult to treat. Since microorganisms need to perpetually adapt to their surrounding environment, understanding the effect of carbon sources on P. aeruginosa physiology is therefore essential to avoid increasin...
Sub-diagnostic effects of genetic variants associated with autism
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While over a hundred genes are significantly associated with autism, little is known about the prevalence of variants affecting them in the general population. Nor do we fully appreciate the phenotypic diversity beyond the formal autism diagnosis. Using data from more than 13,000 autistic individuals and 210,000 undiagnosed individuals, we provide ...
Diversity of Giant Viruses Infecting Vermamoeba vermiformis
The discovery of Acanthamoeba polyphaga mimivirus in 2003 using the free-living amoeba Acanthamoeba polyphaga caused a paradigm shift in the virology field. Twelve years later, using another amoeba as a host, i.e., Vermamoeba vermiformis , novel isolates of giant viruses have been discovered. This amoeba–virus relationship led scientists to study t...
Diving, and even diging, into the wild jungle of annotation pathways for non-vertebrate animals
A recommendation – based on reviews by Cécile Monat, Valentina Peona, Benjamin Istace, Yann Bourgeois – of the article: Guiglielmoni N, Rivera-Vicéns R, Koszul R, Flot J-F (2022) A Deep Dive into Genome Assemblies of Non-vertebrate Animals. Preprints, 2021110170, ver. 3 peer-reviewed and recommended by Peer Community in Genomics. https://doi.org/10...
Relationship between the Chromosome Structural Dynamics and Gene Expression—A Chicken and Egg Dilemma?
Prokaryotic transcription was extensively studied over the last half-century. A great deal of data has been accumulated regarding the control of gene expression by transcription factors regulating their target genes by binding at specific DNA sites. However, there is a significant gap between the mechanistic description of transcriptional control o...
