Laot, Lucie Laas, Enora Girard, Noemie Dumas, Elise Daoud, Eric Grandal, Beatriz Pierga, Jean-Yves Coussy, Florence Kirova, Youlia El-Alam, Elsy
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Published in
Cancers
The three different breast cancer subtypes (Luminal, HER2-positive, and triple negative (TNBCs) display different natural history and sensitivity to treatment, but little is known about whether residual axillary disease after neoadjuvant chemotherapy (NAC) carries a different prognostic value by BC subtype. We retrospectively evaluated the axillary...
Piazzi, Manuela Kojic, Snezana Capanni, Cristina Stamenkovic, Nemanja Bavelloni, Alberto Marin, Oriano Lattanzi, Giovanna Blalock, William Cenni, Vittoria
Published in
Cancers
Ankrd2 is a protein known for being mainly expressed in muscle fibers, where it participates in the mechanical stress response. Since both myocytes and osteoblasts are mesenchymal-derived cells, we were interested in examining the role of Ankrd2 in the progression of osteosarcoma which features a mechano-stress component. Although having been ident...
Pchelina, Daria Schabanel, Nicolas Seki, Shinnosuke Ubukata, Yuki
The Oritatami model was introduced by Geary et al (2016) to study the computational potential of RNA cotranscriptional folding as first shown in wet-lab experiments by Geary et al (Science 2014). In Oritatami model, a molecule grows component by component (named beads) into the triangular grid and folds as it grows. More precisely, the δ last nasce...
Bodnar-Wachtel, Mélanie Huber, Anne-Laure Gorry, Julie Hacot, Sabine Gerossier, Laetitia Guey, Baptiste Goutagny, Nadège Bartosch, Birke Ballot, Elise Ghiringhelli, François
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The DNA damage response (DDR) is essential to preserve genomic integrity and acts as a barrier to cancer. The ATM pathway orchestrates the cellular response to DNA double strand breaks (DSBs), and its attenuation is frequent during tumorigenesis. Here, we show that NLRP3, a Pattern Recognition Receptor known for its role in the inflammasome complex...
Vizzini, Priya Manzano, Marisa Farre, Carole Meylheuc, Thierry Chaix, Carole Ramarao, Nalini Vidic, Jasmina
The authors thank the Centre Technologique des Microstructures of the Lyon 1 University for providing access to its TEM facilities, and the MIMA2 platform Jouy en Josas for access to electron microscopy equipment (MIMA2, INRAE, 2018. Microscopy and Imaging Facility for Microbes, Animals and Foods, https://doi.org/10.15454/1. 5572348210007727E12). J...
Chanut, Julie Lagorce, Aurélie Lequin, Sonia Gougeon, Régis Simon, Jean-Marc Bellat, Jean-Pierre Karbowiak, Thomas
A fast manometric method has been designed for determining the oxygen transfer rate through cork stoppers. Thanks to this technique, it is possible to measure the effective diffusion coefficient of oxygen through a thin cork wafer in a few days, whereas months are required in the case of a full-length cork stopper. A calculation method has also bee...
Cerise, Martina Giaume, Francesca Galli, Mary Khahani, Bahman Lucas, Jérémy Podico, Federico Tavakol, Elahe Parcy, François Gallavotti, Andrea Brambilla, Vittoria
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In rice, the florigens Heading Date 3a (Hd3a) and Rice Flowering Locus T 1 (RFT1), OsFD-like basic leucine zipper (bZIP) transcription factors, and Gf14 proteins assemble into florigen activation/repressor complexes (FACs/FRCs), which regulate transition to flowering in leaves and apical meristem. Only OsFD1 has been described as part of complexes ...
Burgos, Estanislao De Luca, Maria Belen Diouf, Isidore de Haro, Luis Albert, Elise Sauvage, Christopher Jian Tao, Zhao Bermudez, Luisa Asís, Ramon Nunes Nesi, Adriano
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Tocochromanols constitute the different forms of vitamin E (VTE), essential for the human diet and display a high membrane protectant activity. By combining interval mapping and genome-wide association studies (GWAS) we unveiled the genetic determinants of tocochromanol accumulation in tomato fruits. To enhance the nutritional value of this highly ...
Del Cueto, Jorge Kosinska-Cagnazzo, Agnieszka Stefani, Patrick Heritier, Julien Roch, Guillaume Oberhänsli, Thomas Audergon, Jean-Marc Christen, Danilo
Secondary metabolites, such as phenolics, are plant defence substances. In the present study, the impact of Monilinia laxa inoculation under controlled conditions on phenolic content of apricot branches was investigated. A bi-parental hybrid population issued from Bergeron and Bakour cultivars (BerBa) and consisting of 192 hybrids was studied. The ...
Whittaker, Gary R Millet, Jean K
Published in
Methods in molecular biology (Clifton, N.J.)
The coronavirus spike envelope glycoprotein is an essential viral component that mediates virus entry events. Biochemical assessment of the spike protein is critical for understanding structure-function relationships and the roles of the protein in the viral life cycle. Coronavirus spike proteins are typically proteolytically processed and activate...
