Meynier, Maëva Baudu, Elodie Rolhion, Nathalie Defaye, Manon Straube, Marjolène Daugey, Valentine Modoux, Morgane Wawrzyniak, Ivan Delbac, Frédéric Villéger, Romain
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Published in
Gut Microbes
Alterations in brain/gut/microbiota axis are linked to Irritable Bowel Syndrome (IBS) physiopathology. Upon gastrointestinal infection, chronic abdominal pain and anxio-depressive comorbidities may persist despite pathogen clearance leading to Post-Infectious IBS (PI-IBS). This study assesses the influence of tryptophan metabolism, and particularly...
Dib, Fadia Mayaud, Philippe Chauvin, Pierre Launay, Odile
Published in
Human vaccines & immunotherapeutics
The quality of online health information is cause for concern in general, and the spread of mis/disinformation on the benefits and risks of vaccines has certainly been fueling vaccine hesitancy. In the wake of the COVID-19 pandemic, we have entered an era of unprecedented "infodemic." There has never been a more urgent time to address the long-stan...
Nunez, Natalia Derré-Bobillot, Aurélie Trainel, Nicolas Lakisic, Goran Lecomte, Alexandre Mercier-Nomé, Françoise Cassard, Anne-Marie Bierne, Hélène Serror, Pascale Archambaud, Cristel
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Enterococcus faecalis is a bacterial species present at a subdominant level in the human gut microbiota. This commensal turns into an opportunistic pathogen under specific conditions involving dysbiosis and host immune deficiency. E. faecalis is one of the rare pathobionts identified to date as contributing to liver damage in alcoholic liver diseas...
Clary, Bernard Baert, Bélinda Bourrel, Gérard Amouyal, Michel Lognos, Béatrice Oude-Engberink, Agnès Million, Elodie
In 2018, Trèbes, 6,000 inhabitants with nine general practitioners (GPs) in southern France, experienced two tragedies; a terrorist attack in March, in which four people were killed, and a catastrophic flood in October, in which six people died and thousands more were affected.
Darriere, T. Jobet, E. Zavala, D. Escande, M.L. Durut, N. de Bures, A. Blanco-Herrera, F. Vidal, E.A. Rompais, M. Carapito, C.
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Published in
RNA Biology
Transcription and processing of 45S rRNAs in the nucleolus are keystones of ribosome biogenesis. While these processes are severely impacted by stress conditions in multiple species, primarily upon heat exposure, we lack information about the molecular mechanisms allowing sessile organisms without a temperature-control system, like plants, to cope ...
Ducoin, Kathleen Oger, Romain Bilonda Mutala, Linda Deleine, Cécile Jouand, Nicolas Desfrançois, Juliette Podevin, Juliette Duchalais, Emilie Cruard, Jonathan Benlalam, Houssem
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Published in
Oncoimmunology
Laroche, Adrien Orsini Delgado, Maria Lucia Chalopin, Benjamin Cuniasse, Philippe Dubois, Steven Sierocki, Raphaël Gallais, Fabrice Debroas, Stéphanie Bellanger, Laurent Simon, Stéphanie
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Published in
mAbs
Here, we report the molecular engineering of nanobodies that bind with picomolar affinity to both SARS-CoV-1 and SARS-CoV-2 receptor-binding domains (RBD) and are highly neutralizing. We applied deep mutational engineering to VHH72, a nanobody initially specific for SARS-CoV-1 RBD with little cross-reactivity to SARS-CoV-2 antigen. We first identif...
Allende-Vega, Nerea Marco Brualla, Joaquin Falvo, Paolo Alexia, Catherine Constantinides, Michael de Maudave, Alexis Fayd’herbe Coenon, Lois Gitenay, Delphine Mitola, Giulia Massa, Paul
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Published in
Scientific Reports
Solid tumor cells have an altered metabolism that can protect them from cytotoxic lymphocytes. The anti-diabetic drug metformin modifies tumor cell metabolism and several clinical trials are testing its effectiveness for the treatment of solid cancers. The use of metformin in hematologic cancers has received much less attention, although allogeneic...
Mein, Stewart Kopp, Benedikt Vela, Anthony Dutheil, Pauline Lesueur, Paul Stefan, Dinu Debus, Jürgen Haberer, Thomas Abdollahi, Amir Mairani, Andrea
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Published in
Radiation Oncology
BackgroundTo develop an auxiliary GPU-accelerated proton therapy (PT) dose and LETd engine for the IBA Proteus®ONE PT system. A pediatric low-grade glioma case study is reported using FRoG during clinical practice, highlighting potential treatment planning insights using variable RBE dose (DvRBE) and LETd as indicators for clinical decision making ...
Carrat, Fabrice Saba Villarroel, Paola Mariela Lapidus, Nathanaël Fourié, Toscane Blanché, Hélène Dorival, Céline Nicol, Jérôme Deleuze, Jean-François Robineau, Olivier Study Group, Sapris-Sero
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Assessment of the intensity, dynamics and determinants of the antibody response after SARS-CoV-2 infection or vaccination in the general population is critical to guide vaccination policies. This study characterized the anti-spike IgG titers in 13,971 participants included in a French multicohort population-based serological survey on COVID-19 betw...
