Dietary nutrient balance shapes phenotypic traits of Drosophila melanogaster in interaction with gut microbiota
International audience
Neurodevelopmental effects of natural and synthetic ligands of estrogen and progesterone receptors in zebrafish eleuther...
Natural and synthetic estrogens and progestins are widely used in human and veterinary medicine and are detected in waste and surface waters. Our previous studies have clearly shown that a number of these substances targets the brain to induce the estrogen-regulated brain aromatase expression but the consequences on brain development remain virtual...
A 45-years journey within the reproductive brain of fish
International audience
Occupational hazards: Multidisciplinarity to make 'preventability' happen
International audience
Placental serotonin systems in pregnancy metabolic complications associated with maternal obesity and gestational diabet...
Published in Biochimica et biophysica acta. Molecular basis of disease
Serotonin (5-hydroxytryptamine, 5-HT) regulates diverse physiological and behavioural and processes, also acts as a developmental signal in early embryogenesis and in regulation of fetal development. A number of studies have implicated the prominent role of serotonin transporter (SERT or 5-HTT) and 5-HT receptor subtypes in placental development an...
Use of metformin and outcome of patients with newly diagnosed glioblastoma: Pooled analysis.
Published in International journal of cancer
Metformin has been linked to improve survival of patients with various cancers. There is little information on survival of glioblastoma patients after use of metformin. We assessed the association between metformin use and survival in a pooled analysis of patient data from 1,731 individuals from the randomized AVAglio, CENTRIC and CORE trials. We p...
Effect of Hydroxyethyl Starch vs Saline for Volume Replacement Therapy on Death or Postoperative Complications Among Hig...
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ClinicalTrials.gov Identifier: NCT02502773.
Tetramer-Based Enrichment of Preexisting Anti-AAV8 CD8 + T Cells in Human Donors Allows the Detection of a T EMRA Subpop...
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Pre-existing immunity to AAV capsid may compromise the safety and efficiency of rAAV-mediated gene transfer in patients. Anti-capsid cytotoxic immune responses have proven to be a challenge to characterize because of the scarcity of circulating AAV-specific CD8 + T lymphocytes which can seldom be detected with conventional flow cytometry or ELISpot...
Mass Spectrometry Imaging of Specialized Metabolites for Predicting Lichen Fitness and Snail Foraging
Lichens are slow-growing organisms supposed to synthetize specialized metabolites to protect themselves against diverse grazers. As predicted by the optimal defense theory (ODT), lichens are expected to invest specialized metabolites in higher levels in reproductive tissues compared to thallus. We investigated whether Laser Desorption Ionization co...
Emerging technologies to study glial cells
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Development, physiological functions, and pathologies of the brain depend on tight interactions between neurons and different types of glial cells, such as astrocytes, microglia, oligodendrocytes, and oligodendrocyte precursor cells. Assessing the relative contribution of different glial cell types is required for the full understanding of brain fu...
