Liu, Xiaoqing Savy, Alexandra Maurin, Sylvie Grimaud, Laurence François Darchen Quinton, Damien Eric Labbe Buriez, Olivier Delacotte, Jérôme Lemaître, Frédéric
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Published in
Angewandte Chemie International Edition
In this work, Fluorescent False Neurotransmitter 102 (FFN102), a synthesized analogue of biogenic neurotransmit-ters, was demonstrated to show both pH-dependent fluores-cence and electroactivity. To study secretory behaviors at the single-vesicle level, FFN102 was employed as a new fluores-cent/electroactive dual probe in a coupled technique (amper...
Bhatt, Sudhir Valamanesh, Fatemeh Pulpytel, Jérôme Dico, Rea Lo Baiyukha, Aliby Al-dybiat, Iman Marc Pocard Arefi-Khonsari, Farzaneh Mirshahi, Massoud
Published in
Oncotarget
A low pressure plasma process based on plasma deposition has been used todevelop a drug delivery strategy. In this study, a drug delivery system based ondifferent layers of plasma co-polymerized Poly ε-caprolactone-Polyethylene glycol(PCL-PEG) co-polymers was deposited on biocompatible substrates. Cis-platinum(118 μgm/cm2) was used as an anti-cance...
De Leener, Gael Evoung-Evoung, Ferdinand Lascaux, Angelique Mertens, Jérémy Porras-Gutierrez, Ana Gabriela Le Poul, Nicolas Lagrost, Corinne Over, Diana Leroux, Yann R. Reniers, François
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Published in
Journal of the American Chemical Society
The immobilization of a copper calix[6]azacryptand funnel complex on gold-modified electrodes is reported. Two different methodologies are described. One is based on alkyne-terminated thiol self assembled monolayers. The other relies on the electrografting of a calix[4]arene platform bearing diazonium functionalities at its large rim and carboxylic...
Licsandru, Erol Kocsis, Istvan Shen, Yue-xiao Murail, Samuel Legrand, Yves-Marie Van Der Lee, Arie Tsai, Daniel Marc Baaden Kumar, Manish Barboiu, Mihail
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Published in
Journal of the American Chemical Society
Aquaporins (AQPs) are biological water channels known for fast water transport (similar to 10(8)-10(9) molecules/s/channel) with ion exclusion. Few synthetic channels have been designed to mimic this high water permeability, and none reject ions at a significant level. Selective water translocation has previously been shown to depend on water-wires...
Christine Chappard André, Gilles Daudon, Michel Bazin, Dominique
Published in
Comptes Rendus Chimie
Des expérimentations par spectroscopie infrarouge à transformée de Fourier (FTIR) et par diffraction neutronique sur poudres (PND) ont été réalisées sur de l’os sous-chondral humain recouvert (C+) ou non recouvert par le cartilage (C) pour étudier l’hydroxyapatite (HAP).En FTIR, le taux de carbonatation est de 30% avec des spectres identiques pour ...
Le Poul, Nicolas Le Mest, Yves Jabin, Ivan Olivia Reinaud
Published in
Accounts of Chemical Research
Supramolecular bioinorganic chemistry is a natural evolution in biomimetic metallic systems since it constitutes a further degree of complexity in modeling. The traditional approach consisting of mimicking the first coordination sphere of metal sites proved to be very efficient, because valuable data are extracted from these examples to gain insigh...
Mai, Linh H. Chabot, Guy G. Grellier, Philippe Quentin, Lionel Dumontet, Vincent Poulain, Cyril Espindola, Laila S. Sylvie Michel Vo, Hue T.B. Deguin, Brigitte
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Published in
European Journal of Medicinal Chemistry
A series of 16 flavonoids were isolated and prepared from bud exudate of Gardenia urvillei and Gardenia oudiepe, endemic to New Caledonia. Most of them are rare polymethoxylated flavones. Some of these compounds showed noticeable activity against Leishmania (Leishmania) amazonensis, Plasmodium falciparum and Trypanosoma brucei gambiense, in additio...
Otsu, Yo Couchman, Kiri Lyons, Declan G Collot, Mayeul Agarwal, Amit Mallet, Jean-Maurice Pfrieger, Frank W Bergles, Dwight E Charpak, Serge
Published in
Nature neuroscience
Enhanced neuronal activity in the brain triggers a local increase in blood flow, termed functional hyperemia, via several mechanisms, including calcium (Ca(2+)) signaling in astrocytes. However, recent in vivo studies have questioned the role of astrocytes in functional hyperemia because of the slow and sparse dynamics of their somatic Ca(2+) signa...
Khazem, Mays Gaslonde, Thomas Dumontet, Vincent Poullain, Cyril Litaudon, Marc Sylvie Michel
Published in
Phytochemistry Letters
Kermadecin A is a cytotoxic natural macrocycle, containing a bisresorcinol and a pyran ring. A series of derivatives has been synthesized from the natural product in order to investigate the role of the different substructures in the biological activity. In this series, free phenolic groups play an essential role in the biological activity as demon...
Diao, Guiqiang Chau, François Piquemal, Jean-Yves Briot, Emmanuel Souad Ammar Sicard, Mickaël Nowak, Sophie Beaunier, Patricia Lecoq, Hélène Decorse, P.
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Published in
Journal of Nanoparticle Research
Potassium-type birnessite and lithium-containing manganese oxides were prepared by the polyol process. The Mn(III)/Mn(IV) mixed-valencies compounds are obtained through the controlled reduction of potassium permanganate in a basic water–diethylene glycol mixture at moderate temperature and very short reaction time, 70 °C and 10 min, respectively. B...
